ENSG00000100592

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360909 ENSG00000100592 HEK293_OSMI2_6hA HEK293_TMG_6hB DAAM1 protein_coding protein_coding 6.042368 2.862808 8.768894 0.7728315 0.6056353 1.611577 2.7639615 1.0772500 5.246111 0.2288261 0.05660775 2.273312 0.4116500 0.4034667 0.6037 0.2002333 3.787823e-01 1.177063e-17 FALSE TRUE
ENST00000553307 ENSG00000100592 HEK293_OSMI2_6hA HEK293_TMG_6hB DAAM1 protein_coding retained_intron 6.042368 2.862808 8.768894 0.7728315 0.6056353 1.611577 0.4643388 0.9316311 0.000000 0.3226542 0.00000000 -6.557090 0.1980667 0.3090000 0.0000 -0.3090000 1.177063e-17 1.177063e-17 FALSE TRUE
ENST00000554459 ENSG00000100592 HEK293_OSMI2_6hA HEK293_TMG_6hB DAAM1 protein_coding processed_transcript 6.042368 2.862808 8.768894 0.7728315 0.6056353 1.611577 1.6864027 0.5670884 2.650571 0.4498704 0.45719900 2.204872 0.2256167 0.1684667 0.2993 0.1308333 7.395729e-01 1.177063e-17 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000100592 E001 0.1779838 0.040682971 1.0000000000   14 59188646 59188666 21 + 0.070 0.000 -9.289
ENSG00000100592 E002 0.8627522 0.017267182 0.8054268095   14 59188667 59188679 13 + 0.230 0.203 -0.226
ENSG00000100592 E003 3.7093692 0.054045577 0.4685195243 0.679029426 14 59188680 59188698 19 + 0.632 0.534 -0.444
ENSG00000100592 E004 11.1369387 0.002738695 0.0251435605 0.112661596 14 59188699 59188768 70 + 1.059 0.843 -0.811
ENSG00000100592 E005 1.6806719 0.036712281 0.8930885569 0.948193302 14 59188769 59188914 146 + 0.378 0.445 0.361
ENSG00000100592 E006 10.0901631 0.003016163 0.0139886541 0.074302365 14 59263441 59263454 14 + 1.025 0.761 -1.008
ENSG00000100592 E007 34.7979681 0.025155483 0.0332111959 0.136615273 14 59263455 59263660 206 + 1.517 1.339 -0.614
ENSG00000100592 E008 0.1426347 0.033161795 1.0000000000   14 59263661 59266161 2501 + 0.070 0.000 -9.278
ENSG00000100592 E009 26.5553982 0.052586308 0.0771463211 0.239089158 14 59291217 59291306 90 + 1.408 1.202 -0.719
ENSG00000100592 E010 0.1308682 0.032649190 0.1547546551   14 59291307 59291508 202 + 0.000 0.203 12.788
ENSG00000100592 E011 0.1779838 0.040682971 1.0000000000   14 59299715 59300015 301 + 0.070 0.000 -9.282
ENSG00000100592 E012 23.0892987 0.010771674 0.0052361989 0.035864605 14 59315280 59315351 72 + 1.358 1.130 -0.804
ENSG00000100592 E013 24.9059531 0.002128136 0.0013616800 0.012625278 14 59320490 59320584 95 + 1.387 1.168 -0.769
ENSG00000100592 E014 40.6945205 0.014774096 0.0017005157 0.015019851 14 59322892 59323225 334 + 1.588 1.372 -0.741
ENSG00000100592 E015 21.5988253 0.014670307 0.0287592493 0.123645114 14 59324128 59324238 111 + 1.315 1.148 -0.589
ENSG00000100592 E016 0.0000000       14 59324350 59324350 1 +      
ENSG00000100592 E017 9.8123047 0.003196406 0.0062515351 0.040960471 14 59324351 59324353 3 + 1.025 0.714 -1.200
ENSG00000100592 E018 19.5647815 0.002168173 0.0433454686 0.163451927 14 59324354 59324454 101 + 1.274 1.149 -0.441
ENSG00000100592 E019 17.0136531 0.051717849 0.2893825847 0.529926768 14 59325664 59325730 67 + 1.206 1.123 -0.297
ENSG00000100592 E020 27.1296647 0.035094564 0.4826409044 0.688821224 14 59325960 59326077 118 + 1.383 1.376 -0.023
ENSG00000100592 E021 0.0000000       14 59326078 59326115 38 +      
ENSG00000100592 E022 31.8194903 0.001255073 0.4594198864 0.672740356 14 59326510 59326648 139 + 1.442 1.454 0.039
ENSG00000100592 E023 23.4713494 0.002116080 0.6887297048 0.828292627 14 59326933 59326991 59 + 1.309 1.340 0.106
ENSG00000100592 E024 29.6755402 0.001375965 0.0696780000 0.224148264 14 59330501 59330688 188 + 1.434 1.363 -0.248
ENSG00000100592 E025 19.7748696 0.002518422 0.5859751243 0.760937526 14 59331209 59331429 221 + 1.245 1.262 0.059
ENSG00000100592 E026 20.8444701 0.007905518 0.6408155481 0.797421231 14 59331430 59331508 79 + 1.258 1.277 0.066
ENSG00000100592 E027 27.9361673 0.023464051 0.7293714596 0.853867985 14 59331813 59331920 108 + 1.379 1.406 0.094
ENSG00000100592 E028 0.0000000       14 59338385 59338414 30 +      
ENSG00000100592 E029 33.5999148 0.010485185 0.4328637514 0.653400953 14 59340074 59340180 107 + 1.463 1.463 -0.001
ENSG00000100592 E030 20.4322244 0.008298853 0.5709542100 0.750973224 14 59347539 59347546 8 + 1.255 1.262 0.028
ENSG00000100592 E031 34.4045091 0.001191003 0.7406317849 0.860821230 14 59347547 59347623 77 + 1.464 1.506 0.144
ENSG00000100592 E032 35.3940287 0.005127401 0.4348402507 0.654871233 14 59352526 59352632 107 + 1.457 1.579 0.418
ENSG00000100592 E033 26.5280268 0.004973236 0.7816580875 0.885621259 14 59353876 59353939 64 + 1.362 1.404 0.147
ENSG00000100592 E034 24.2891010 0.013112264 0.3116162004 0.551993303 14 59353940 59353964 25 + 1.343 1.312 -0.108
ENSG00000100592 E035 0.0000000       14 59355161 59355164 4 +      
ENSG00000100592 E036 25.4879269 0.004689942 0.5676592071 0.748529285 14 59355165 59355232 68 + 1.352 1.372 0.071
ENSG00000100592 E037 27.8132721 0.002229775 0.5748473556 0.753555045 14 59355233 59355333 101 + 1.384 1.406 0.077
ENSG00000100592 E038 0.3228314 0.427768430 0.9927183501   14 59357301 59357330 30 + 0.130 0.000 -10.286
ENSG00000100592 E039 0.4466850 0.023627495 0.4462808627   14 59359255 59359396 142 + 0.183 0.000 -10.862
ENSG00000100592 E040 30.9032532 0.002254100 0.8421675686 0.920686385 14 59359397 59359504 108 + 1.422 1.472 0.171
ENSG00000100592 E041 0.7804750 0.023774561 0.8142100654   14 59360642 59360801 160 + 0.230 0.203 -0.224
ENSG00000100592 E042 28.9244115 0.001517081 0.5108054261 0.708580168 14 59360802 59360862 61 + 1.377 1.489 0.384
ENSG00000100592 E043 6.9260461 0.004807572 0.5391496640 0.728390393 14 59362261 59363650 1390 + 0.807 0.942 0.520
ENSG00000100592 E044 39.7643242 0.001332229 0.2375779989 0.473801501 14 59363651 59363782 132 + 1.501 1.637 0.466
ENSG00000100592 E045 45.4723220 0.001124952 0.2792963571 0.519415494 14 59367429 59367599 171 + 1.561 1.688 0.431
ENSG00000100592 E046 225.6372049 0.042454747 0.0005652701 0.006267275 14 59368650 59371405 2756 + 2.182 2.508 1.086