ENSG00000100591

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000216479 ENSG00000100591 HEK293_OSMI2_6hA HEK293_TMG_6hB AHSA1 protein_coding protein_coding 288.111 279.4873 299.3837 42.97899 13.59492 0.09920951 203.29356 210.02697 188.14570 38.542257 8.0283472 -0.15871626 0.70363333 0.74316667 0.6288000 -0.11436667 1.567046e-01 9.508928e-14 FALSE TRUE
ENST00000554156 ENSG00000100591 HEK293_OSMI2_6hA HEK293_TMG_6hB AHSA1 protein_coding retained_intron 288.111 279.4873 299.3837 42.97899 13.59492 0.09920951 34.85002 37.83553 37.02153 3.883751 0.6851587 -0.03136849 0.12260000 0.13873333 0.1243667 -0.01436667 8.778244e-01 9.508928e-14 FALSE TRUE
ENST00000556866 ENSG00000100591 HEK293_OSMI2_6hA HEK293_TMG_6hB AHSA1 protein_coding retained_intron 288.111 279.4873 299.3837 42.97899 13.59492 0.09920951 20.78459 11.88347 49.62833 1.255339 4.9105041 2.06128554 0.07187083 0.04346667 0.1650667 0.12160000 9.508928e-14 9.508928e-14 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000100591 E001 5.9421355 0.1963439056 0.3491719419 0.586534122 14 77457870 77457982 113 + 0.973 0.705 -1.046
ENSG00000100591 E002 0.3751086 0.0273509630 0.3148737683   14 77458032 77458032 1 + 0.000 0.197 9.849
ENSG00000100591 E003 0.6979399 0.0990189893 0.7738361259   14 77458033 77458036 4 + 0.238 0.198 -0.341
ENSG00000100591 E004 155.3883700 1.1294452900 0.3962764932 0.625377845 14 77458037 77458092 56 + 2.038 2.279 0.805
ENSG00000100591 E005 885.4680243 1.7416333902 0.5141000578 0.711042090 14 77458093 77458216 124 + 2.818 3.020 0.674
ENSG00000100591 E006 906.3865088 1.7620112951 0.5412375492 0.729942829 14 77458217 77458269 53 + 2.846 3.021 0.583
ENSG00000100591 E007 1054.9880419 1.8152383282 0.5573068448 0.741360156 14 77459616 77459668 53 + 2.920 3.083 0.543
ENSG00000100591 E008 843.5397380 1.7536023940 0.5701340598 0.750353597 14 77459669 77459699 31 + 2.835 2.979 0.479
ENSG00000100591 E009 1148.5709812 0.0571361799 0.4065275489 0.633429111 14 77459700 77459744 45 + 3.004 3.093 0.294
ENSG00000100591 E010 1143.1966004 0.0083531347 0.9925642311 0.997944830 14 77459745 77459780 36 + 3.035 3.070 0.116
ENSG00000100591 E011 1153.8090901 0.0000726046 0.0001539438 0.002145875 14 77459781 77459806 26 + 3.058 3.061 0.010
ENSG00000100591 E012 8.8872215 0.1481225634 0.8582303672 0.929412387 14 77459807 77460214 408 + 0.996 0.989 -0.026
ENSG00000100591 E013 1501.2200497 0.0027978940 0.0054468034 0.036950925 14 77462160 77462242 83 + 3.182 3.166 -0.055
ENSG00000100591 E014 3.2158555 0.1777858636 0.5873607346 0.761868012 14 77462243 77462319 77 + 0.674 0.578 -0.417
ENSG00000100591 E015 1751.1251122 0.0075342902 0.1165720553 0.310082799 14 77462642 77462759 118 + 3.242 3.238 -0.012
ENSG00000100591 E016 15.5469394 0.1358001856 0.0070936304 0.045044398 14 77462760 77463101 342 + 1.416 0.942 -1.695
ENSG00000100591 E017 10.0935844 0.0043195087 0.0057945826 0.038720918 14 77464583 77464597 15 + 1.161 0.911 -0.918
ENSG00000100591 E018 1506.7941695 0.0143192396 0.2482280132 0.486037579 14 77464598 77464686 89 + 3.175 3.174 -0.005
ENSG00000100591 E019 4.7165861 0.0100641760 0.0013214931 0.012321287 14 77464687 77464690 4 + 0.938 0.517 -1.744
ENSG00000100591 E020 973.8269230 0.0147599986 0.4344400323 0.654574118 14 77465539 77465573 35 + 2.975 2.992 0.058
ENSG00000100591 E021 1457.6986157 0.0182872911 0.7807990077 0.885170327 14 77465574 77465667 94 + 3.133 3.179 0.153
ENSG00000100591 E022 1583.6474763 0.0181168687 0.9045449392 0.954227907 14 77468083 77468184 102 + 3.163 3.220 0.189
ENSG00000100591 E023 9.6682195 0.0038775038 0.0036315424 0.027100207 14 77468185 77468319 135 + 1.150 0.879 -0.998
ENSG00000100591 E024 1307.1495250 0.0160117499 0.3751513428 0.608313933 14 77468457 77468508 52 + 3.108 3.116 0.029
ENSG00000100591 E025 21.9983581 0.0637199874 0.8393160587 0.919018479 14 77468590 77468689 100 + 1.341 1.364 0.079
ENSG00000100591 E026 14.3909313 0.0448528711 0.7696944404 0.878480970 14 77468690 77468760 71 + 1.128 1.214 0.305
ENSG00000100591 E027 21.4053481 0.0049997175 0.1588071049 0.374961404 14 77468796 77468971 176 + 1.386 1.316 -0.246
ENSG00000100591 E028 14.2745945 0.0520730221 0.3660160380 0.600768786 14 77468972 77468985 14 + 1.223 1.148 -0.269
ENSG00000100591 E029 34.2209659 0.0094136920 0.3138616700 0.554086764 14 77468986 77469076 91 + 1.560 1.529 -0.106
ENSG00000100591 E030 2042.6815456 0.0163394494 0.6246714649 0.787133694 14 77469077 77469472 396 + 3.287 3.321 0.110