ENSG00000100504

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000216392 ENSG00000100504 HEK293_OSMI2_6hA HEK293_TMG_6hB PYGL protein_coding protein_coding 123.9956 83.54533 138.6695 17.5485 7.275715 0.7309508 83.31077 62.4650634 87.666781 14.5145471 3.419946 0.4889144 0.66762083 0.7390333 0.6333000 -0.10573333 0.20541255 0.04430469 FALSE TRUE
ENST00000530336 ENSG00000100504 HEK293_OSMI2_6hA HEK293_TMG_6hB PYGL protein_coding retained_intron 123.9956 83.54533 138.6695 17.5485 7.275715 0.7309508 23.83248 12.2337612 27.340575 1.4823337 1.660592 1.1595243 0.19836250 0.1559333 0.1969667 0.04103333 0.67205739 0.04430469 FALSE TRUE
MSTRG.9511.11 ENSG00000100504 HEK293_OSMI2_6hA HEK293_TMG_6hB PYGL protein_coding   123.9956 83.54533 138.6695 17.5485 7.275715 0.7309508 3.98947 0.3012901 8.859968 0.3012901 2.249186 4.8325973 0.02664167 0.0031000 0.0627000 0.05960000 0.04430469 0.04430469 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000100504 E001 0.8217936 0.0201935416 7.774746e-01   14 50857891 50858169 279 - 0.278 0.230 -0.365
ENSG00000100504 E002 2.4791885 0.2127823984 5.619853e-01 7.446560e-01 14 50905207 50905216 10 - 0.599 0.446 -0.731
ENSG00000100504 E003 2.1753258 0.3531399856 5.919157e-01 7.650298e-01 14 50905217 50905217 1 - 0.566 0.391 -0.877
ENSG00000100504 E004 8.4214259 0.0040006902 7.190839e-01 8.476043e-01 14 50905218 50905221 4 - 0.986 0.954 -0.120
ENSG00000100504 E005 862.0081975 0.0073846586 7.824497e-02 2.412892e-01 14 50905222 50905556 335 - 2.891 2.981 0.298
ENSG00000100504 E006 5.5877243 0.0379102413 2.088728e-02 9.898031e-02 14 50908142 50908270 129 - 0.946 0.579 -1.487
ENSG00000100504 E007 526.6386363 0.0059849530 1.313177e-01 3.338808e-01 14 50908271 50908337 67 - 2.685 2.760 0.251
ENSG00000100504 E008 762.8745549 0.0043179808 4.387841e-02 1.648065e-01 14 50908821 50908955 135 - 2.843 2.924 0.272
ENSG00000100504 E009 1014.5280125 0.0030505433 3.988437e-02 1.544156e-01 14 50909895 50910102 208 - 2.973 3.043 0.232
ENSG00000100504 E010 779.8703535 0.0001574547 1.347217e-02 7.227064e-02 14 50911730 50911871 142 - 2.877 2.918 0.137
ENSG00000100504 E011 515.7276253 0.0135981306 3.317925e-01 5.706408e-01 14 50911978 50912036 59 - 2.690 2.739 0.164
ENSG00000100504 E012 537.7502797 0.0757936160 2.900642e-01 5.306370e-01 14 50912156 50912222 67 - 2.685 2.777 0.305
ENSG00000100504 E013 463.8795503 1.1334392385 4.624629e-01 6.748311e-01 14 50912223 50912303 81 - 2.587 2.742 0.518
ENSG00000100504 E014 491.9332471 1.7231277395 5.343150e-01 7.251514e-01 14 50913029 50913130 102 - 2.607 2.771 0.546
ENSG00000100504 E015 537.3893654 0.0183670367 1.474883e-01 3.587302e-01 14 50914701 50914815 115 - 2.688 2.775 0.292
ENSG00000100504 E016 0.6731895 0.0562887228 4.004631e-01   14 50915190 50915335 146 - 0.279 0.130 -1.371
ENSG00000100504 E017 627.6412792 0.0001230623 2.928061e-01 5.335183e-01 14 50915336 50915499 164 - 2.792 2.816 0.077
ENSG00000100504 E018 482.0205808 0.0013479160 5.344454e-01 7.252214e-01 14 50915825 50915971 147 - 2.675 2.698 0.078
ENSG00000100504 E019 466.8245089 0.0024147478 8.982123e-01 9.508894e-01 14 50916642 50916734 93 - 2.670 2.674 0.014
ENSG00000100504 E020 421.6175328 0.0054416419 2.057997e-01 4.368090e-01 14 50916962 50917015 54 - 2.645 2.604 -0.137
ENSG00000100504 E021 495.2863767 0.0038590797 3.381259e-01 5.763775e-01 14 50917016 50917105 90 - 2.708 2.682 -0.087
ENSG00000100504 E022 457.6220753 0.0019961575 5.409830e-01 7.297285e-01 14 50920541 50920623 83 - 2.652 2.676 0.080
ENSG00000100504 E023 506.1786812 0.0010934518 4.290814e-01 6.503455e-01 14 50920956 50921067 112 - 2.696 2.721 0.085
ENSG00000100504 E024 35.5432774 0.0685508265 6.721745e-02 2.188679e-01 14 50921068 50921528 461 - 1.666 1.395 -0.926
ENSG00000100504 E025 217.6051816 0.0178438693 2.314669e-02 1.064086e-01 14 50923237 50923659 423 - 2.409 2.241 -0.559
ENSG00000100504 E026 271.4657510 0.0217382898 3.115943e-03 2.410856e-02 14 50923660 50923932 273 - 2.529 2.294 -0.783
ENSG00000100504 E027 150.3359441 0.0262977827 5.340234e-03 3.638785e-02 14 50923933 50923968 36 - 2.278 2.028 -0.836
ENSG00000100504 E028 792.5556377 0.0023759987 1.655188e-04 2.284050e-03 14 50923969 50924100 132 - 2.943 2.845 -0.324
ENSG00000100504 E029 688.4064276 0.0032140535 9.580770e-07 2.736352e-05 14 50931673 50931776 104 - 2.901 2.754 -0.489
ENSG00000100504 E030 593.3192238 0.0052012310 3.710500e-06 8.898388e-05 14 50935107 50935185 79 - 2.845 2.675 -0.568
ENSG00000100504 E031 525.3854233 0.0082039701 2.588968e-03 2.089272e-02 14 50937736 50937837 102 - 2.781 2.641 -0.466
ENSG00000100504 E032 3.4212487 0.0075804219 4.900640e-01 6.940283e-01 14 50941047 50941107 61 - 0.602 0.713 0.474
ENSG00000100504 E033 620.3405995 0.0068792527 1.520504e-01 3.653370e-01 14 50944161 50944442 282 - 2.820 2.760 -0.200
ENSG00000100504 E034 109.8676402 0.0040697835 9.009586e-07 2.594159e-05 14 50944443 50944483 41 - 1.924 2.152 0.766
ENSG00000100504 E035 0.1614157 0.0338955980 5.670100e-01   14 50944884 50944910 27 - 0.114 0.000 -8.251