ENSG00000100503

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000382043 ENSG00000100503 HEK293_OSMI2_6hA HEK293_TMG_6hB NIN protein_coding protein_coding 10.93422 7.274654 17.27665 1.290028 0.6214123 1.246726 1.8699547 1.3100743 4.6952841 0.1691638 0.32905003 1.833663 0.1554458 0.1839667 0.27226667 0.08830000 0.24632998 0.01091785 FALSE TRUE
ENST00000389869 ENSG00000100503 HEK293_OSMI2_6hA HEK293_TMG_6hB NIN protein_coding protein_coding 10.93422 7.274654 17.27665 1.290028 0.6214123 1.246726 0.8115756 1.3334839 0.4702281 0.3009339 0.27627559 -1.484187 0.0934125 0.1799333 0.02693333 -0.15300000 0.20370553 0.01091785 FALSE TRUE
ENST00000486200 ENSG00000100503 HEK293_OSMI2_6hA HEK293_TMG_6hB NIN protein_coding processed_transcript 10.93422 7.274654 17.27665 1.290028 0.6214123 1.246726 0.6974610 0.8127189 0.4011562 0.3274654 0.04975008 -1.000713 0.0905125 0.1045000 0.02346667 -0.08103333 0.01091785 0.01091785 FALSE FALSE
ENST00000530997 ENSG00000100503 HEK293_OSMI2_6hA HEK293_TMG_6hB NIN protein_coding protein_coding 10.93422 7.274654 17.27665 1.290028 0.6214123 1.246726 5.1576898 2.6304495 8.9932089 0.4120211 0.11553272 1.769656 0.4445125 0.3685000 0.52153333 0.15303333 0.12317807 0.01091785 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000100503 E001 0.5470056 0.2459144615 5.194026e-01   14 50719763 50719816 54 - 0.153 0.288 1.154
ENSG00000100503 E002 2.4284362 0.0096250299 1.270910e-01 0.3271783846 14 50719817 50719838 22 - 0.434 0.687 1.171
ENSG00000100503 E003 168.1301397 0.0052181847 4.860898e-03 0.0338760788 14 50719839 50720472 634 - 2.149 2.285 0.454
ENSG00000100503 E004 98.5757726 0.0044554467 7.221034e-01 0.8493527607 14 50720473 50720892 420 - 1.958 1.982 0.082
ENSG00000100503 E005 383.7736203 0.0002004441 1.715429e-04 0.0023514355 14 50720893 50723380 2488 - 2.573 2.505 -0.228
ENSG00000100503 E006 26.3806246 0.0033418221 2.328478e-02 0.1068380715 14 50723381 50723417 37 - 1.461 1.287 -0.602
ENSG00000100503 E007 28.1028907 0.0076683727 2.529322e-03 0.0205235340 14 50723418 50723450 33 - 1.504 1.252 -0.874
ENSG00000100503 E008 71.3384301 0.0005303208 7.467258e-06 0.0001627663 14 50723451 50723672 222 - 1.883 1.673 -0.710
ENSG00000100503 E009 1.1474014 0.0355798073 9.067824e-01   14 50725827 50725827 1 - 0.317 0.295 -0.145
ENSG00000100503 E010 1.4927703 0.0199691966 8.691933e-01 0.9355026190 14 50725828 50725832 5 - 0.359 0.391 0.180
ENSG00000100503 E011 1.6955045 0.0299582501 5.437173e-01 0.7317389518 14 50725833 50725839 7 - 0.359 0.470 0.600
ENSG00000100503 E012 15.4724030 0.0235698065 2.656685e-03 0.0213179972 14 50725840 50725952 113 - 1.038 1.381 1.220
ENSG00000100503 E013 76.9385958 0.0077213997 5.861325e-01 0.7610358929 14 50725953 50726066 114 - 1.844 1.884 0.135
ENSG00000100503 E014 2.3743737 0.0105281092 7.283215e-01 0.8532522708 14 50726067 50726414 348 - 0.526 0.468 -0.282
ENSG00000100503 E015 5.4888117 0.0404293409 2.573539e-01 0.4960964184 14 50727236 50727578 343 - 0.725 0.912 0.736
ENSG00000100503 E016 6.2688388 0.0092721908 1.859143e-02 0.0910369375 14 50727579 50727688 110 - 0.724 1.028 1.172
ENSG00000100503 E017 6.6513602 0.0045679981 3.420699e-01 0.5798097062 14 50727689 50727751 63 - 0.818 0.942 0.474
ENSG00000100503 E018 102.1413133 0.0051394440 1.043189e-01 0.2893974338 14 50729523 50729723 201 - 1.952 2.038 0.287
ENSG00000100503 E019 0.0000000       14 50730923 50730983 61 -      
ENSG00000100503 E020 85.8764828 0.0006232233 1.803204e-02 0.0891434374 14 50735516 50735617 102 - 1.869 1.971 0.343
ENSG00000100503 E021 115.5630591 0.0020083018 5.253655e-02 0.1855677951 14 50738140 50738286 147 - 2.004 2.088 0.282
ENSG00000100503 E022 86.7425172 0.0023658274 3.133855e-01 0.5536144069 14 50739308 50739371 64 - 1.893 1.947 0.180
ENSG00000100503 E023 93.4278816 0.0005741559 2.191397e-03 0.0183424339 14 50739372 50739487 116 - 1.901 2.026 0.419
ENSG00000100503 E024 113.2905330 0.0005002903 3.042041e-03 0.0236661590 14 50741582 50741728 147 - 1.987 2.097 0.370
ENSG00000100503 E025 1.8908414 0.3630427613 1.570452e-01 0.3723365254 14 50741729 50742385 657 - 0.275 0.651 1.977
ENSG00000100503 E026 98.5996403 0.0004094702 4.117770e-01 0.6373493513 14 50743416 50743529 114 - 1.956 1.993 0.125
ENSG00000100503 E027 104.4811786 0.0005336651 1.449655e-02 0.0762276075 14 50744243 50744365 123 - 1.958 2.053 0.320
ENSG00000100503 E028 99.5177579 0.0005926098 4.410504e-03 0.0314364571 14 50747992 50748105 114 - 1.929 2.042 0.378
ENSG00000100503 E029 128.5463885 0.0019735143 1.352704e-03 0.0125537030 14 50752518 50752733 216 - 2.039 2.166 0.426
ENSG00000100503 E030 69.0320793 0.0011425762 3.440491e-03 0.0259873906 14 50754563 50754632 70 - 1.770 1.910 0.471
ENSG00000100503 E031 73.1446692 0.0006691772 1.725766e-01 0.3938965066 14 50754742 50754867 126 - 1.818 1.884 0.222
ENSG00000100503 E032 260.2397676 0.0021824679 2.850682e-01 0.5256880392 14 50756492 50757787 1296 - 2.374 2.410 0.121
ENSG00000100503 E033 146.5731205 0.0051267374 4.062011e-01 0.6331903124 14 50757788 50758630 843 - 2.147 2.109 -0.127
ENSG00000100503 E034 84.2859921 0.0028188795 4.650625e-02 0.1713046956 14 50759857 50759993 137 - 1.922 1.829 -0.314
ENSG00000100503 E035 139.7368413 0.0022034932 2.934877e-02 0.1254362014 14 50759994 50760359 366 - 2.139 2.056 -0.278
ENSG00000100503 E036 73.3877107 0.0017924855 2.131879e-02 0.1003718722 14 50761790 50761911 122 - 1.871 1.761 -0.369
ENSG00000100503 E037 0.6246688 0.0192102379 1.829854e-01   14 50761912 50761972 61 - 0.269 0.000 -13.918
ENSG00000100503 E038 73.6938041 0.0032743031 3.072983e-02 0.1295331492 14 50763826 50763964 139 - 1.874 1.764 -0.372
ENSG00000100503 E039 49.8870833 0.0039920148 3.244739e-01 0.5637841167 14 50766307 50766396 90 - 1.691 1.635 -0.192
ENSG00000100503 E040 60.2285994 0.0006329615 9.540188e-02 0.2737005915 14 50766780 50766890 111 - 1.780 1.703 -0.262
ENSG00000100503 E041 69.9427014 0.0005902338 5.220709e-02 0.1848538154 14 50770388 50770517 130 - 1.846 1.761 -0.286
ENSG00000100503 E042 50.3731484 0.0008166368 2.856759e-02 0.1230422553 14 50770518 50770562 45 - 1.715 1.599 -0.392
ENSG00000100503 E043 79.9351847 0.0060308330 1.500519e-01 0.3624067804 14 50770852 50770992 141 - 1.901 1.819 -0.276
ENSG00000100503 E044 0.3453689 0.0285386315 5.532887e-01   14 50771316 50771331 16 - 0.084 0.172 1.180
ENSG00000100503 E045 73.5085715 0.0006933069 6.400908e-02 0.2116804505 14 50771332 50771468 137 - 1.865 1.786 -0.268
ENSG00000100503 E046 0.3447487 0.7018683286 1.646312e-01   14 50771986 50772300 315 - 0.000 0.300 11.881
ENSG00000100503 E047 71.7043718 0.0006749664 1.502007e-03 0.0136352911 14 50772301 50772468 168 - 1.874 1.731 -0.484
ENSG00000100503 E048 58.1057737 0.0006919229 1.568198e-04 0.0021809517 14 50772949 50773095 147 - 1.794 1.600 -0.658
ENSG00000100503 E049 71.9872355 0.0014399996 5.085217e-04 0.0057580136 14 50776949 50777139 191 - 1.878 1.711 -0.563
ENSG00000100503 E050 42.5541648 0.0008157251 3.773675e-02 0.1489231648 14 50778765 50778804 40 - 1.643 1.525 -0.403
ENSG00000100503 E051 0.0000000       14 50792046 50792049 4 -      
ENSG00000100503 E052 4.5071459 0.0130434805 6.621934e-05 0.0010589045 14 50792050 50792261 212 - 0.434 1.010 2.429
ENSG00000100503 E053 0.1426347 0.0321478377 1.000000e+00   14 50792460 50792513 54 - 0.084 0.000 -11.761
ENSG00000100503 E054 64.1872610 0.0017485648 5.319148e-01 0.7234032520 14 50792712 50792843 132 - 1.795 1.771 -0.081
ENSG00000100503 E055 37.7428539 0.0175914260 3.988124e-01 0.6272859811 14 50792844 50792881 38 - 1.583 1.518 -0.223
ENSG00000100503 E056 0.5963342 0.0212664127 8.125005e-01   14 50794436 50794525 90 - 0.216 0.171 -0.411
ENSG00000100503 E057 0.3751086 0.0304950077 5.827907e-02   14 50805917 50806207 291 - 0.000 0.295 13.404
ENSG00000100503 E058 0.5481031 0.3349243281 2.843372e-01   14 50806208 50806276 69 - 0.084 0.304 2.252
ENSG00000100503 E059 0.0000000       14 50806277 50806736 460 -      
ENSG00000100503 E060 42.2400112 0.0699624566 9.008964e-01 0.9523233860 14 50806737 50806818 82 - 1.601 1.620 0.066
ENSG00000100503 E061 37.0751652 0.2514004410 5.458328e-01 0.7333346020 14 50821874 50822000 127 - 1.526 1.599 0.250
ENSG00000100503 E062 19.2493790 0.0573993640 7.764474e-01 0.8825927649 14 50822001 50822077 77 - 1.271 1.303 0.112
ENSG00000100503 E063 10.4710852 0.0032679173 8.857188e-01 0.9443874682 14 50830464 50830517 54 - 1.028 1.048 0.076
ENSG00000100503 E064 0.3150090 0.0307880056 5.518565e-01   14 50830518 50830723 206 - 0.084 0.172 1.178
ENSG00000100503 E065 7.7278096 0.0040510865 4.141113e-01 0.6390693412 14 50831006 50831181 176 - 0.884 0.987 0.389