ENSG00000100441

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000553935 ENSG00000100441 HEK293_OSMI2_6hA HEK293_TMG_6hB KHNYN protein_coding protein_coding 12.90271 17.46191 8.648092 0.7658752 0.1628621 -1.012917 6.0572789 10.1510052 2.5374471 0.9987288 0.5453086 -1.9959191 0.45602917 0.57986667 0.29200000 -0.28786667 0.04286085 0.00600493 FALSE TRUE
ENST00000556255 ENSG00000100441 HEK293_OSMI2_6hA HEK293_TMG_6hB KHNYN protein_coding retained_intron 12.90271 17.46191 8.648092 0.7658752 0.1628621 -1.012917 0.6413618 0.5030902 0.5775816 0.2975041 0.1979459 0.1955768 0.05246667 0.03046667 0.06623333 0.03576667 0.59109872 0.00600493 FALSE TRUE
ENST00000556510 ENSG00000100441 HEK293_OSMI2_6hA HEK293_TMG_6hB KHNYN protein_coding protein_coding 12.90271 17.46191 8.648092 0.7658752 0.1628621 -1.012917 0.9372409 1.3009674 0.7325943 0.2007410 0.1061283 -0.8199856 0.07510417 0.07533333 0.08483333 0.00950000 0.94878597 0.00600493 FALSE TRUE
ENST00000556842 ENSG00000100441 HEK293_OSMI2_6hA HEK293_TMG_6hB KHNYN protein_coding protein_coding 12.90271 17.46191 8.648092 0.7658752 0.1628621 -1.012917 4.2371442 4.0470737 4.3608987 0.3860830 0.3467641 0.1074904 0.34230833 0.23393333 0.50526667 0.27133333 0.00600493 0.00600493 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000100441 E001 0.000000       14 24429286 24429407 122 +      
ENSG00000100441 E002 0.738161 0.0172671820 4.971237e-01   14 24429935 24429937 3 + 0.315 0.200 -0.866
ENSG00000100441 E003 2.607257 0.0080857308 6.408100e-01 0.797421231 14 24429938 24429953 16 + 0.564 0.498 -0.311
ENSG00000100441 E004 16.804983 0.0020957203 2.243858e-02 0.104046168 14 24429954 24429991 38 + 1.003 1.255 0.906
ENSG00000100441 E005 29.023916 0.0017356015 9.709601e-06 0.000204377 14 24429992 24430119 128 + 1.105 1.505 1.403
ENSG00000100441 E006 11.783176 0.0031329185 2.219378e-01 0.455824994 14 24430224 24430482 259 + 1.140 1.031 -0.391
ENSG00000100441 E007 10.294986 0.0069026932 1.064185e-01 0.293031273 14 24430483 24430551 69 + 1.123 0.963 -0.584
ENSG00000100441 E008 9.255347 0.0048492534 5.716846e-01 0.751456675 14 24430552 24430623 72 + 1.003 0.954 -0.180
ENSG00000100441 E009 5.316615 0.0275140346 8.764757e-01 0.939445389 14 24430624 24430713 90 + 0.763 0.755 -0.035
ENSG00000100441 E010 42.267577 0.0054965257 4.153308e-04 0.004880820 14 24430714 24430764 51 + 1.358 1.645 0.983
ENSG00000100441 E011 81.178771 0.5438785029 3.417726e-01 0.579529080 14 24430765 24430931 167 + 1.729 1.900 0.576
ENSG00000100441 E012 434.154009 0.0024091716 7.071204e-01 0.839988922 14 24431463 24432610 1148 + 2.574 2.588 0.047
ENSG00000100441 E013 116.227157 0.0005008278 3.446256e-04 0.004184867 14 24432722 24432793 72 + 2.094 1.986 -0.362
ENSG00000100441 E014 103.146487 0.0003732736 7.355743e-04 0.007745857 14 24432794 24432852 59 + 2.040 1.933 -0.360
ENSG00000100441 E015 121.486374 0.0003749304 6.794090e-03 0.043672842 14 24432936 24433032 97 + 2.088 2.013 -0.251
ENSG00000100441 E016 10.108278 0.2265077499 9.918644e-02 0.280329180 14 24435457 24436067 611 + 1.193 0.896 -1.087
ENSG00000100441 E017 2.320510 0.0915635582 7.369071e-01 0.858548704 14 24436068 24436071 4 + 0.413 0.502 0.453
ENSG00000100441 E018 112.654346 0.0004960289 8.697078e-01 0.935693376 14 24436072 24436179 108 + 1.982 2.008 0.089
ENSG00000100441 E019 120.936950 0.0061684790 5.508955e-01 0.736977779 14 24436388 24436489 102 + 2.035 2.031 -0.012
ENSG00000100441 E020 1464.203582 0.0037304931 1.996091e-01 0.429167442 14 24437036 24441843 4808 + 3.078 3.122 0.146