ENSG00000100393

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263253 ENSG00000100393 HEK293_OSMI2_6hA HEK293_TMG_6hB EP300 protein_coding protein_coding 16.85869 23.04533 17.66638 3.367459 0.5745125 -0.3832776 8.369739 9.010431 11.8539306 1.173831 0.34333429 0.3953138 0.492250 0.3966667 0.67206667 0.275400000 8.094867e-04 2.621271e-19 FALSE TRUE
ENST00000635083 ENSG00000100393 HEK293_OSMI2_6hA HEK293_TMG_6hB EP300 protein_coding retained_intron 16.85869 23.04533 17.66638 3.367459 0.5745125 -0.3832776 3.624601 7.149500 0.3971399 1.589837 0.01586026 -4.1362624 0.219725 0.3023000 0.02256667 -0.279733333 2.621271e-19 2.621271e-19 FALSE TRUE
ENST00000674155 ENSG00000100393 HEK293_OSMI2_6hA HEK293_TMG_6hB EP300 protein_coding protein_coding 16.85869 23.04533 17.66638 3.367459 0.5745125 -0.3832776 4.452818 6.577300 5.0843289 1.042660 0.54707578 -0.3707952 0.262150 0.2856000 0.28663333 0.001033333 1.000000e+00 2.621271e-19 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000100393 E001 55.3115081 0.0052846251 9.796667e-04 9.753763e-03 22 41092592 41093004 413 + 1.829 1.683 -0.494
ENSG00000100393 E002 51.9770295 0.0011239059 3.531983e-07 1.139244e-05 22 41093005 41093098 94 + 1.827 1.614 -0.722
ENSG00000100393 E003 0.5061644 0.3969398871 7.735370e-01   22 41108025 41108098 74 + 0.129 0.208 0.831
ENSG00000100393 E004 261.5851336 0.0002121442 1.279118e-13 1.559394e-11 22 41117187 41117770 584 + 2.481 2.360 -0.404
ENSG00000100393 E005 73.6093291 0.0005881031 1.487700e-03 1.352783e-02 22 41117771 41117821 51 + 1.921 1.832 -0.298
ENSG00000100393 E006 0.1426347 0.0322651014 3.988628e-01   22 41125852 41125863 12 + 0.128 0.000 -9.467
ENSG00000100393 E007 112.6011112 0.0003762707 5.344469e-05 8.815208e-04 22 41125864 41126040 177 + 2.104 2.012 -0.310
ENSG00000100393 E008 0.7497398 0.0417180396 8.569701e-01   22 41126041 41126308 268 + 0.227 0.280 0.396
ENSG00000100393 E009 132.7502084 0.0046505362 1.244810e-03 1.175540e-02 22 41127487 41127748 262 + 2.180 2.076 -0.349
ENSG00000100393 E010 95.9937615 0.0096643087 4.657731e-03 3.277872e-02 22 41129890 41130003 114 + 2.052 1.925 -0.427
ENSG00000100393 E011 98.9994406 0.0004555473 2.809120e-06 7.017553e-05 22 41131388 41131532 145 + 2.065 1.940 -0.420
ENSG00000100393 E012 86.1851926 0.0022578542 3.545725e-03 2.662123e-02 22 41131533 41131633 101 + 1.987 1.901 -0.290
ENSG00000100393 E013 84.2672949 0.0036553411 1.688483e-04 2.321995e-03 22 41135813 41135906 94 + 2.001 1.859 -0.477
ENSG00000100393 E014 127.7847410 0.0003237161 4.655920e-11 3.534566e-09 22 41137653 41137790 138 + 2.192 2.028 -0.551
ENSG00000100393 E015 119.3982694 0.0004371076 2.041752e-09 1.123943e-07 22 41140140 41140257 118 + 2.159 2.005 -0.517
ENSG00000100393 E016 126.8958293 0.0003993168 2.357801e-04 3.066293e-03 22 41141048 41141222 175 + 2.148 2.073 -0.249
ENSG00000100393 E017 0.0000000       22 41146553 41146738 186 +      
ENSG00000100393 E018 82.5997798 0.0006633804 6.082220e-02 2.046645e-01 22 41146739 41146816 78 + 1.940 1.908 -0.107
ENSG00000100393 E019 96.1089774 0.0004366599 1.674292e-01 3.871483e-01 22 41147837 41147946 110 + 1.995 1.988 -0.024
ENSG00000100393 E020 0.0000000       22 41148819 41149037 219 +      
ENSG00000100393 E021 116.8768712 0.0004722615 1.234527e-01 3.212109e-01 22 41149038 41149175 138 + 2.076 2.067 -0.031
ENSG00000100393 E022 231.9101163 0.0019666803 5.215417e-03 3.575689e-02 22 41149761 41150198 438 + 2.392 2.345 -0.158
ENSG00000100393 E023 160.6608454 0.0048627376 3.108261e-03 2.406661e-02 22 41151833 41152012 180 + 2.254 2.164 -0.303
ENSG00000100393 E024 142.0673427 0.0025772744 3.207259e-01 5.603218e-01 22 41152206 41152350 145 + 2.157 2.159 0.008
ENSG00000100393 E025 164.0873329 0.0003008247 1.656001e-01 3.846819e-01 22 41154995 41155113 119 + 2.216 2.220 0.013
ENSG00000100393 E026 97.8278892 0.0006135494 3.735068e-01 6.069566e-01 22 41157169 41157199 31 + 1.989 1.999 0.033
ENSG00000100393 E027 203.9356864 0.0003736905 7.450744e-03 4.680258e-02 22 41157200 41157408 209 + 2.325 2.299 -0.087
ENSG00000100393 E028 111.3495555 0.0003855752 3.334732e-01 5.720224e-01 22 41158412 41158467 56 + 2.048 2.059 0.036
ENSG00000100393 E029 105.5526638 0.0004729956 7.797521e-02 2.407502e-01 22 41158468 41158500 33 + 2.040 2.021 -0.061
ENSG00000100393 E030 10.7763387 0.1030210467 1.822645e-01 4.069379e-01 22 41158501 41160419 1919 + 1.165 0.976 -0.686
ENSG00000100393 E031 137.5627538 0.0003918521 5.528440e-01 7.382801e-01 22 41160642 41160722 81 + 2.109 2.171 0.207
ENSG00000100393 E032 73.3568956 0.0006726423 6.076562e-01 7.753176e-01 22 41162723 41162726 4 + 1.861 1.883 0.074
ENSG00000100393 E033 119.8047135 0.0003884451 9.131795e-01 9.587152e-01 22 41162727 41162779 53 + 2.062 2.102 0.134
ENSG00000100393 E034 134.9931498 0.0003878998 6.031993e-01 7.723467e-01 22 41164053 41164130 78 + 2.101 2.160 0.199
ENSG00000100393 E035 126.0715403 0.0012483959 8.985547e-01 9.511137e-01 22 41166599 41166666 68 + 2.083 2.122 0.129
ENSG00000100393 E036 195.1601881 0.0003576498 4.919520e-01 6.952911e-01 22 41168449 41168599 151 + 2.258 2.319 0.204
ENSG00000100393 E037 182.7564727 0.0112608287 3.235570e-01 5.628821e-01 22 41168721 41168867 147 + 2.213 2.304 0.305
ENSG00000100393 E038 0.7802874 0.0173030959 4.864391e-01   22 41169283 41169502 220 + 0.308 0.205 -0.773
ENSG00000100393 E039 137.1440837 0.1501241747 4.040368e-01 6.315558e-01 22 41169503 41169616 114 + 2.065 2.194 0.433
ENSG00000100393 E040 201.5514552 0.0093850610 5.419365e-01 7.304461e-01 22 41170406 41170571 166 + 2.271 2.335 0.214
ENSG00000100393 E041 201.4939509 0.0008065655 3.255734e-01 5.647815e-01 22 41172499 41172663 165 + 2.269 2.337 0.228
ENSG00000100393 E042 188.9137319 0.0002913764 1.136588e-03 1.094148e-02 22 41173623 41173784 162 + 2.208 2.338 0.434
ENSG00000100393 E043 7.7838603 0.1677849823 7.273242e-01 8.526379e-01 22 41176059 41176246 188 + 0.934 0.944 0.035
ENSG00000100393 E044 244.4150750 0.0002197098 2.155142e-02 1.011281e-01 22 41176247 41176528 282 + 2.338 2.435 0.323
ENSG00000100393 E045 1719.5688851 0.0021737873 8.355730e-18 1.852474e-15 22 41176773 41180077 3305 + 3.114 3.317 0.677