ENSG00000100239

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000395744 ENSG00000100239 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP6R2 protein_coding protein_coding 44.88863 65.75661 30.59173 2.715712 0.6337831 -1.103742 3.750701 7.730580 1.2243780 3.8737431 1.2243780 -2.6486574 0.07902083 0.11616667 0.04093333 -0.07523333 0.65359830 0.01434904 FALSE TRUE
ENST00000401672 ENSG00000100239 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP6R2 protein_coding protein_coding 44.88863 65.75661 30.59173 2.715712 0.6337831 -1.103742 4.169516 7.961551 0.4933914 2.6108992 0.4933914 -3.9851079 0.07146250 0.11970000 0.01550000 -0.10420000 0.18010894 0.01434904 FALSE TRUE
ENST00000470046 ENSG00000100239 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP6R2 protein_coding retained_intron 44.88863 65.75661 30.59173 2.715712 0.6337831 -1.103742 6.480365 9.596046 4.8789654 2.2918993 0.1737984 -0.9744135 0.14334167 0.14686667 0.15983333 0.01296667 0.93242267 0.01434904 FALSE FALSE
ENST00000473283 ENSG00000100239 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP6R2 protein_coding retained_intron 44.88863 65.75661 30.59173 2.715712 0.6337831 -1.103742 2.554677 3.677846 2.1353644 1.2140341 0.4496190 -0.7815557 0.05788750 0.05660000 0.06923333 0.01263333 0.87083917 0.01434904   FALSE
ENST00000612753 ENSG00000100239 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP6R2 protein_coding protein_coding 44.88863 65.75661 30.59173 2.715712 0.6337831 -1.103742 6.813610 7.919441 3.2116757 0.4845347 0.4874003 -1.2994080 0.13998333 0.12100000 0.10460000 -0.01640000 0.86303031 0.01434904 FALSE TRUE
MSTRG.22375.13 ENSG00000100239 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP6R2 protein_coding   44.88863 65.75661 30.59173 2.715712 0.6337831 -1.103742 8.185481 12.810847 9.6848720 1.3541472 0.3308290 -0.4031978 0.20212917 0.19393333 0.31686667 0.12293333 0.01434904 0.01434904 TRUE TRUE
MSTRG.22375.22 ENSG00000100239 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP6R2 protein_coding   44.88863 65.75661 30.59173 2.715712 0.6337831 -1.103742 3.480963 4.694484 2.9288559 1.6877806 0.1423354 -0.6787819 0.08279583 0.07190000 0.09590000 0.02400000 0.76181252 0.01434904 FALSE TRUE
MSTRG.22375.9 ENSG00000100239 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP6R2 protein_coding   44.88863 65.75661 30.59173 2.715712 0.6337831 -1.103742 3.107451 3.920176 2.2098758 0.2097094 0.4376918 -0.8241151 0.07714583 0.05993333 0.07286667 0.01293333 0.91247648 0.01434904 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000100239 E001 0.3032425 0.0244411696 6.917732e-01   22 50343304 50343320 17 + 0.000 0.144 9.379
ENSG00000100239 E002 0.4341107 0.0244411696 4.162039e-01   22 50343321 50343322 2 + 0.000 0.201 12.251
ENSG00000100239 E003 0.5649788 0.0277540989 2.724568e-01   22 50343323 50343326 4 + 0.000 0.251 12.624
ENSG00000100239 E004 0.9153370 0.0194291683 6.112575e-01   22 50343327 50343329 3 + 0.184 0.297 0.892
ENSG00000100239 E005 0.9153370 0.0194291683 6.112575e-01   22 50343330 50343330 1 + 0.184 0.297 0.892
ENSG00000100239 E006 1.2076208 0.0224493566 9.780545e-01   22 50343331 50343331 1 + 0.314 0.338 0.152
ENSG00000100239 E007 1.5108633 0.0418810639 7.139590e-01 8.443188e-01 22 50343332 50343334 3 + 0.314 0.408 0.558
ENSG00000100239 E008 2.9457812 0.0091077410 1.066869e-01 2.934726e-01 22 50343335 50343339 5 + 0.313 0.637 1.657
ENSG00000100239 E009 3.0766493 0.0140151963 9.080630e-02 2.652162e-01 22 50343340 50343341 2 + 0.313 0.656 1.736
ENSG00000100239 E010 4.2908597 0.0269294966 1.949931e-01 4.233430e-01 22 50343342 50343344 3 + 0.493 0.753 1.143
ENSG00000100239 E011 4.8614480 0.0581807196 3.240092e-01 5.633225e-01 22 50343345 50343345 1 + 0.562 0.790 0.966
ENSG00000100239 E012 6.8383119 0.0909290710 2.232315e-01 4.572331e-01 22 50343346 50343346 1 + 0.622 0.916 1.186
ENSG00000100239 E013 9.3194349 0.0876553956 9.930406e-02 2.805591e-01 22 50343347 50343355 9 + 0.674 1.044 1.434
ENSG00000100239 E014 14.4613097 0.0548329436 4.889220e-03 3.402737e-02 22 50343356 50343368 13 + 0.720 1.233 1.919
ENSG00000100239 E015 74.5856300 0.0221392298 2.013258e-01 4.313790e-01 22 50343369 50343550 182 + 1.718 1.859 0.477
ENSG00000100239 E016 0.8699390 0.1358592506 2.087882e-01   22 50360134 50360195 62 + 0.000 0.300 12.299
ENSG00000100239 E017 70.3728410 0.0188830738 5.723765e-01 7.519529e-01 22 50372020 50372071 52 + 1.812 1.795 -0.057
ENSG00000100239 E018 132.9859811 0.0032848917 1.072257e-04 1.585355e-03 22 50372072 50372150 79 + 2.169 2.034 -0.450
ENSG00000100239 E019 8.7574016 0.0087783833 9.225965e-03 5.482473e-02 22 50388986 50389033 48 + 1.120 0.840 -1.040
ENSG00000100239 E020 15.6374524 0.0210610756 4.877512e-01 6.924844e-01 22 50389034 50389111 78 + 1.211 1.155 -0.200
ENSG00000100239 E021 5.4450358 0.0052365175 1.883135e-01 4.148335e-01 22 50391867 50392015 149 + 0.866 0.711 -0.617
ENSG00000100239 E022 4.6788504 0.0976980054 4.854705e-01 6.908913e-01 22 50393750 50393799 50 + 0.793 0.668 -0.512
ENSG00000100239 E023 351.0267113 0.0001963400 3.605691e-10 2.275471e-08 22 50393893 50394135 243 + 2.566 2.466 -0.333
ENSG00000100239 E024 194.7112162 0.0002782292 2.934734e-05 5.294649e-04 22 50406689 50406734 46 + 2.303 2.217 -0.286
ENSG00000100239 E025 301.7487387 0.0002055596 6.971190e-07 2.076962e-05 22 50406735 50406875 141 + 2.488 2.407 -0.269
ENSG00000100239 E026 259.4330258 0.0021558058 8.513393e-02 2.548421e-01 22 50414552 50414689 138 + 2.381 2.356 -0.084
ENSG00000100239 E027 190.6529628 0.0036314380 4.156379e-01 6.402929e-01 22 50416092 50416157 66 + 2.230 2.228 -0.005
ENSG00000100239 E028 251.5709096 0.0025833773 2.919653e-01 5.326380e-01 22 50418867 50418979 113 + 2.354 2.350 -0.013
ENSG00000100239 E029 5.4039161 0.2470859093 1.176840e-01 3.120044e-01 22 50418980 50418989 10 + 0.983 0.630 -1.398
ENSG00000100239 E030 9.1071081 0.0095445147 2.968161e-01 5.373307e-01 22 50419346 50419348 3 + 1.021 0.920 -0.378
ENSG00000100239 E031 272.6313059 0.0002396094 4.774927e-01 6.853780e-01 22 50419349 50419441 93 + 2.376 2.391 0.048
ENSG00000100239 E032 175.7328388 0.0002859333 4.312907e-01 6.521510e-01 22 50419442 50419462 21 + 2.193 2.201 0.026
ENSG00000100239 E033 277.5156804 0.0020804188 4.128627e-01 6.382800e-01 22 50422254 50422380 127 + 2.388 2.394 0.020
ENSG00000100239 E034 283.4596284 0.0045674409 1.969477e-01 4.257414e-01 22 50423462 50423604 143 + 2.416 2.396 -0.066
ENSG00000100239 E035 136.0024163 0.0003551965 9.338302e-01 9.690136e-01 22 50423605 50423614 10 + 2.063 2.092 0.096
ENSG00000100239 E036 397.6278052 0.0007156944 1.084091e-01 2.964106e-01 22 50431173 50431382 210 + 2.553 2.547 -0.020
ENSG00000100239 E037 248.0149680 0.0008170149 1.512019e-01 3.640710e-01 22 50432265 50432329 65 + 2.351 2.342 -0.030
ENSG00000100239 E038 347.6637304 0.0002455003 5.266398e-01 7.195831e-01 22 50434966 50435081 116 + 2.479 2.497 0.060
ENSG00000100239 E039 283.1593353 0.0005644658 7.145717e-01 8.446783e-01 22 50436367 50436452 86 + 2.386 2.409 0.076
ENSG00000100239 E040 41.2464614 0.1229571871 9.795701e-02 2.781930e-01 22 50436701 50436987 287 + 1.725 1.502 -0.761
ENSG00000100239 E041 195.2836841 0.0002299610 4.947865e-04 5.626875e-03 22 50436988 50437068 81 + 2.290 2.224 -0.221
ENSG00000100239 E042 378.6063974 0.0002063315 1.756585e-02 8.752158e-02 22 50437506 50437603 98 + 2.541 2.523 -0.059
ENSG00000100239 E043 331.6995245 0.0001981732 7.622334e-03 4.757226e-02 22 50437843 50437900 58 + 2.490 2.463 -0.091
ENSG00000100239 E044 387.7045589 0.0010250668 1.999837e-01 4.296643e-01 22 50438174 50438298 125 + 2.538 2.537 -0.003
ENSG00000100239 E045 423.7803028 0.0001740942 9.920631e-01 9.977444e-01 22 50438599 50438762 164 + 2.553 2.585 0.106
ENSG00000100239 E046 17.0780040 0.0254073233 6.454839e-01 8.004925e-01 22 50439698 50439700 3 + 1.138 1.222 0.298
ENSG00000100239 E047 287.7717395 0.0001991393 1.566877e-01 3.717953e-01 22 50439701 50439752 52 + 2.362 2.428 0.221
ENSG00000100239 E048 310.2357014 0.0002251161 1.407505e-01 3.486689e-01 22 50439753 50439857 105 + 2.393 2.460 0.223
ENSG00000100239 E049 15.5290645 0.0532373737 4.586654e-01 6.722637e-01 22 50439858 50439960 103 + 1.223 1.146 -0.275
ENSG00000100239 E050 272.3446335 0.0002241974 6.863716e-03 4.401045e-02 22 50439961 50440049 89 + 2.312 2.413 0.336
ENSG00000100239 E051 9.2129810 0.0406757753 2.043866e-01 4.350930e-01 22 50440801 50440821 21 + 1.063 0.912 -0.561
ENSG00000100239 E052 276.9411690 0.0034132199 4.491918e-03 3.189626e-02 22 50440822 50440955 134 + 2.289 2.426 0.457
ENSG00000100239 E053 196.5200400 0.0350321598 3.037149e-02 1.284569e-01 22 50440956 50441026 71 + 2.068 2.293 0.754
ENSG00000100239 E054 20.7157228 0.1135475477 5.293566e-01 7.215984e-01 22 50441027 50441074 48 + 1.310 1.277 -0.117
ENSG00000100239 E055 174.6985998 0.3492397777 4.525146e-01 6.675300e-01 22 50443087 50443865 779 + 2.075 2.228 0.510
ENSG00000100239 E056 435.4290644 1.3978809629 4.155682e-01 6.402751e-01 22 50443866 50444117 252 + 2.361 2.646 0.953
ENSG00000100239 E057 121.4062475 0.9530341123 3.981403e-01 6.268278e-01 22 50444199 50444202 4 + 1.854 2.086 0.777
ENSG00000100239 E058 191.5261581 1.0994853832 3.761377e-01 6.091050e-01 22 50444203 50444312 110 + 2.014 2.290 0.923
ENSG00000100239 E059 110.2036283 0.6710244593 3.055795e-01 5.462264e-01 22 50444313 50444649 337 + 1.793 2.048 0.856
ENSG00000100239 E060 112.6531032 0.7099228177 3.468935e-01 5.844706e-01 22 50444650 50445090 441 + 1.822 2.054 0.777