ENSG00000100207

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000335626 ENSG00000100207 HEK293_OSMI2_6hA HEK293_TMG_6hB TCF20 protein_coding protein_coding 11.53799 13.34778 10.68542 1.949891 0.3738302 -0.3206862 2.626522 1.999099 4.1158052 0.3726212 0.1163399 1.0381273 0.2272125 0.1478333 0.3853667 0.2375333 2.033161e-08 2.033161e-08 FALSE TRUE
ENST00000359486 ENSG00000100207 HEK293_OSMI2_6hA HEK293_TMG_6hB TCF20 protein_coding protein_coding 11.53799 13.34778 10.68542 1.949891 0.3738302 -0.3206862 4.293916 5.746675 3.2461016 0.9287213 0.4708063 -0.8220901 0.3742792 0.4316667 0.3019667 -0.1297000 3.617051e-01 2.033161e-08 FALSE TRUE
ENST00000404876 ENSG00000100207 HEK293_OSMI2_6hA HEK293_TMG_6hB TCF20 protein_coding protein_coding 11.53799 13.34778 10.68542 1.949891 0.3738302 -0.3206862 2.521429 4.153804 0.7817578 0.8131004 0.2023295 -2.3947712 0.2159708 0.3064333 0.0745000 -0.2319333 1.126865e-04 2.033161e-08 FALSE TRUE
ENST00000677622 ENSG00000100207 HEK293_OSMI2_6hA HEK293_TMG_6hB TCF20 protein_coding protein_coding 11.53799 13.34778 10.68542 1.949891 0.3738302 -0.3206862 1.266278 1.001710 2.0864500 0.3800974 0.1696008 1.0511529 0.1102250 0.0789000 0.1953667 0.1164667 2.383288e-01 2.033161e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000100207 E001 2.1244152 0.010245652 3.485141e-04 4.224533e-03 22 42160013 42160052 40 - 0.000 0.662 12.464
ENSG00000100207 E002 238.1271486 1.345929369 3.434504e-01 5.811251e-01 22 42160053 42161055 1003 - 2.162 2.478 1.054
ENSG00000100207 E003 9.7677645 0.021120414 1.767756e-02 8.792598e-02 22 42161056 42161097 42 - 0.822 1.123 1.123
ENSG00000100207 E004 7.3585439 0.066269954 2.511818e-01 4.892580e-01 22 42161098 42161141 44 - 0.817 0.989 0.655
ENSG00000100207 E005 59.8473592 0.553318009 1.422211e-01 3.507465e-01 22 42161142 42161358 217 - 1.520 1.900 1.289
ENSG00000100207 E006 23.5107077 0.001591668 4.785941e-03 3.345667e-02 22 42168609 42168703 95 - 1.245 1.457 0.738
ENSG00000100207 E007 13.3717939 0.002953016 6.636334e-02 2.168813e-01 22 42168704 42168736 33 - 1.033 1.210 0.635
ENSG00000100207 E008 55.3991525 0.050392739 1.633208e-02 8.301170e-02 22 42169847 42169896 50 - 1.558 1.842 0.962
ENSG00000100207 E009 89.3512525 0.004214948 1.941032e-05 3.727180e-04 22 42179609 42179702 94 - 1.810 2.023 0.717
ENSG00000100207 E010 223.6387678 0.001209698 5.377152e-09 2.679516e-07 22 42209651 42210123 473 - 2.237 2.403 0.555
ENSG00000100207 E011 534.3434128 0.001608512 5.171878e-01 7.131231e-01 22 42210124 42211512 1389 - 2.727 2.718 -0.030
ENSG00000100207 E012 771.4692814 0.005301465 2.445360e-08 1.051604e-06 22 42211513 42214620 3108 - 2.957 2.819 -0.459
ENSG00000100207 E013 65.9597647 0.013721979 4.403444e-04 5.131097e-03 22 42214621 42214846 226 - 1.945 1.705 -0.810
ENSG00000100207 E014 81.2298569 0.002925766 8.162655e-06 1.758519e-04 22 42214847 42215178 332 - 2.015 1.815 -0.675
ENSG00000100207 E015 39.2652007 0.003555359 8.827697e-05 1.346216e-03 22 42215179 42215341 163 - 1.722 1.484 -0.809
ENSG00000100207 E016 0.1426347 0.031482331 3.641977e-01   22 42215342 42215440 99 - 0.139 0.000 -11.695
ENSG00000100207 E017 10.9018329 0.092741341 2.517073e-01 4.897367e-01 22 42268313 42269616 1304 - 1.165 0.984 -0.657
ENSG00000100207 E018 5.6056999 0.014855997 3.311133e-02 1.363564e-01 22 42270339 42270653 315 - 0.968 0.685 -1.111
ENSG00000100207 E019 0.0000000       22 42283827 42283997 171 -      
ENSG00000100207 E020 0.1723744 0.035729018 6.428570e-01   22 42318064 42318239 176 - 0.000 0.106 10.405
ENSG00000100207 E021 0.6977523 0.024697209 4.805748e-01   22 42343479 42343616 138 - 0.139 0.262 1.139