ENSG00000100029

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000335214 ENSG00000100029 HEK293_OSMI2_6hA HEK293_TMG_6hB PES1 protein_coding protein_coding 254.7362 297.6109 150.0615 43.19715 5.227758 -0.987826 18.08973 13.96724 16.10917 3.136008 1.050091 0.2056975 0.08078750 0.04643333 0.1071000 0.06066667 1.044637e-03 2.826564e-39 FALSE TRUE
ENST00000354694 ENSG00000100029 HEK293_OSMI2_6hA HEK293_TMG_6hB PES1 protein_coding protein_coding 254.7362 297.6109 150.0615 43.19715 5.227758 -0.987826 202.30307 250.90959 113.89303 39.535423 3.411819 -1.1394190 0.78829583 0.83930000 0.7594333 -0.07986667 1.041430e-01 2.826564e-39 FALSE TRUE
ENST00000441668 ENSG00000100029 HEK293_OSMI2_6hA HEK293_TMG_6hB PES1 protein_coding protein_coding 254.7362 297.6109 150.0615 43.19715 5.227758 -0.987826 19.48553 21.06764 0.00000 3.061408 0.000000 -11.0414978 0.05127917 0.07143333 0.0000000 -0.07143333 2.826564e-39 2.826564e-39 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000100029 E001 2.4154139 1.411976e-02 2.611396e-02 1.156784e-01 22 30576625 30576627 3 - 0.177 0.611 2.614
ENSG00000100029 E002 3.4153112 6.594072e-02 1.433615e-01 3.524995e-01 22 30576628 30576629 2 - 0.399 0.700 1.415
ENSG00000100029 E003 7.0830426 7.978954e-03 4.436198e-02 1.659804e-01 22 30576630 30576631 2 - 0.656 0.946 1.149
ENSG00000100029 E004 25.8424556 1.418742e-03 2.797592e-02 1.211947e-01 22 30576632 30576635 4 - 1.258 1.435 0.613
ENSG00000100029 E005 63.6881865 8.093975e-04 6.061555e-01 7.743067e-01 22 30576636 30576648 13 - 1.789 1.766 -0.076
ENSG00000100029 E006 99.6307376 1.335017e-03 1.122340e-02 6.328625e-02 22 30576649 30576663 15 - 1.878 1.989 0.375
ENSG00000100029 E007 108.7074617 2.432183e-03 1.313824e-02 7.101390e-02 22 30576664 30576664 1 - 1.914 2.027 0.379
ENSG00000100029 E008 850.0311275 1.627316e-03 4.427920e-07 1.392008e-05 22 30576665 30576834 170 - 2.795 2.919 0.414
ENSG00000100029 E009 2416.0759397 4.679041e-04 2.411508e-19 6.388916e-17 22 30576835 30577129 295 - 3.254 3.370 0.386
ENSG00000100029 E010 2228.3623529 1.683327e-04 1.014547e-35 1.276247e-32 22 30578837 30578995 159 - 3.210 3.339 0.429
ENSG00000100029 E011 878.3409624 3.096255e-04 5.153262e-15 7.884165e-13 22 30578996 30578998 3 - 2.809 2.936 0.421
ENSG00000100029 E012 8.8029171 1.088429e-01 5.348099e-02 1.878566e-01 22 30578999 30579136 138 - 0.655 1.040 1.503
ENSG00000100029 E013 2538.0009467 7.228994e-05 1.267282e-06 3.487919e-05 22 30579137 30579303 167 - 3.332 3.374 0.139
ENSG00000100029 E014 23.8747002 2.238521e-02 1.389625e-01 3.459304e-01 22 30579304 30579750 447 - 1.458 1.300 -0.548
ENSG00000100029 E015 2382.0551651 7.642532e-05 1.538398e-01 3.678166e-01 22 30579751 30579935 185 - 3.342 3.331 -0.037
ENSG00000100029 E016 26.8043323 4.309874e-02 4.610099e-01 6.738638e-01 22 30579936 30580052 117 - 1.473 1.372 -0.350
ENSG00000100029 E017 1712.8265459 5.189498e-04 2.682216e-01 5.078626e-01 22 30580053 30580178 126 - 3.178 3.195 0.057
ENSG00000100029 E018 1498.6445424 2.835597e-04 3.581918e-02 1.437649e-01 22 30580571 30580686 116 - 3.113 3.141 0.093
ENSG00000100029 E019 714.3260373 1.133580e-04 1.899159e-02 9.243403e-02 22 30580687 30580701 15 - 2.786 2.823 0.126
ENSG00000100029 E020 1119.0185847 8.609647e-05 1.632695e-02 8.300227e-02 22 30581012 30581101 90 - 2.984 3.016 0.104
ENSG00000100029 E021 1044.8212483 1.525191e-04 3.004612e-09 1.583650e-07 22 30581334 30581408 75 - 3.029 2.954 -0.250
ENSG00000100029 E022 1210.2714695 1.034132e-04 2.410366e-16 4.363919e-14 22 30581528 30581644 117 - 3.105 3.012 -0.311
ENSG00000100029 E023 11.2803309 1.075129e-01 6.709384e-01 8.169514e-01 22 30584227 30584364 138 - 1.096 1.031 -0.237
ENSG00000100029 E024 770.3902457 1.450552e-04 2.705032e-12 2.585124e-10 22 30584365 30584415 51 - 2.915 2.815 -0.332
ENSG00000100029 E025 761.9688362 1.094057e-04 2.421744e-08 1.042240e-06 22 30584416 30584454 39 - 2.894 2.816 -0.261
ENSG00000100029 E026 1614.8332239 5.298403e-05 8.666938e-14 1.091280e-11 22 30584546 30584717 172 - 3.216 3.145 -0.234
ENSG00000100029 E027 21.8703705 4.580816e-02 2.057881e-02 9.795270e-02 22 30585224 30585370 147 - 1.504 1.211 -1.020
ENSG00000100029 E028 29.9388311 2.423113e-02 1.648982e-05 3.241898e-04 22 30586998 30587285 288 - 1.704 1.278 -1.466
ENSG00000100029 E029 1538.2035579 7.786829e-04 9.190522e-08 3.440833e-06 22 30587286 30587395 110 - 3.202 3.117 -0.281
ENSG00000100029 E030 1987.1473776 5.729682e-04 2.157713e-11 1.755770e-09 22 30588021 30588174 154 - 3.318 3.226 -0.305
ENSG00000100029 E031 1246.1704465 8.176811e-04 6.264825e-05 1.009883e-03 22 30589191 30589270 80 - 3.101 3.032 -0.232
ENSG00000100029 E032 1.6308252 1.219891e-02 5.193875e-01 7.146193e-01 22 30591794 30591809 16 - 0.303 0.424 0.715
ENSG00000100029 E033 836.1008227 5.085257e-04 2.381145e-03 1.957087e-02 22 30591810 30591917 108 - 2.917 2.865 -0.171
ENSG00000100029 E034 0.3088520 2.639449e-02 5.113046e-01   22 30592132 30592398 267 - 0.177 0.081 -1.291
ENSG00000100029 E035 0.0000000       22 30603778 30603779 2 -      
ENSG00000100029 E036 0.7980729 1.869604e-02 1.344403e-01   22 30603780 30604102 323 - 0.000 0.308 11.472
ENSG00000100029 E037 0.3336024 2.444117e-02 5.760862e-01   22 30605414 30605460 47 - 0.000 0.150 10.021
ENSG00000100029 E038 0.8395791 1.705112e-02 1.321974e-01   22 30605461 30605517 57 - 0.000 0.308 11.521
ENSG00000100029 E039 0.3032425 2.744240e-02 5.758704e-01   22 30606809 30607083 275 - 0.000 0.150 9.965