ENSG00000099991

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263119 ENSG00000099991 HEK293_OSMI2_6hA HEK293_TMG_6hB CABIN1 protein_coding protein_coding 43.23058 67.06724 29.90085 7.481069 1.228104 -1.165155 14.206348 21.0493804 14.93902285 2.1807213 2.26186685 -0.4944118 0.35518750 0.31476667 0.49650000 0.18173333 0.1929882157 1.99856e-05 FALSE TRUE
ENST00000337989 ENSG00000099991 HEK293_OSMI2_6hA HEK293_TMG_6hB CABIN1 protein_coding protein_coding 43.23058 67.06724 29.90085 7.481069 1.228104 -1.165155 4.376579 4.3956174 0.06595834 1.3069272 0.04445637 -5.8579920 0.07541250 0.06283333 0.00230000 -0.06053333 0.0001430608 1.99856e-05 FALSE TRUE
ENST00000398319 ENSG00000099991 HEK293_OSMI2_6hA HEK293_TMG_6hB CABIN1 protein_coding protein_coding 43.23058 67.06724 29.90085 7.481069 1.228104 -1.165155 8.052500 14.3954027 3.28276445 2.8077683 2.11256699 -2.1292388 0.18010833 0.21036667 0.11373333 -0.09663333 0.7764517546 1.99856e-05 FALSE TRUE
ENST00000445422 ENSG00000099991 HEK293_OSMI2_6hA HEK293_TMG_6hB CABIN1 protein_coding protein_coding 43.23058 67.06724 29.90085 7.481069 1.228104 -1.165155 2.417216 0.7300166 5.55198139 0.7300166 1.07175738 2.9099694 0.08293333 0.01353333 0.18410000 0.17056667 0.0764056772 1.99856e-05 FALSE TRUE
ENST00000459824 ENSG00000099991 HEK293_OSMI2_6hA HEK293_TMG_6hB CABIN1 protein_coding retained_intron 43.23058 67.06724 29.90085 7.481069 1.228104 -1.165155 4.403566 7.4833051 2.09422076 0.7324512 0.27304560 -1.8323161 0.09512500 0.11533333 0.06956667 -0.04576667 0.4415792039 1.99856e-05   FALSE
ENST00000485008 ENSG00000099991 HEK293_OSMI2_6hA HEK293_TMG_6hB CABIN1 protein_coding processed_transcript 43.23058 67.06724 29.90085 7.481069 1.228104 -1.165155 2.733378 4.7124349 1.61493245 0.7611229 0.29951554 -1.5391512 0.06075000 0.07150000 0.05493333 -0.01656667 0.8241975637 1.99856e-05 FALSE TRUE
MSTRG.21812.11 ENSG00000099991 HEK293_OSMI2_6hA HEK293_TMG_6hB CABIN1 protein_coding   43.23058 67.06724 29.90085 7.481069 1.228104 -1.165155 2.780018 4.5644219 0.67721750 0.4309728 0.04681561 -2.7347507 0.05728333 0.06833333 0.02283333 -0.04550000 0.0000199856 1.99856e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000099991 E001 0.2617363 0.0760120899 7.002164e-01   22 24011192 24011303 112 + 0.000 0.140 9.745
ENSG00000099991 E002 0.2617363 0.0760120899 7.002164e-01   22 24011304 24011314 11 + 0.000 0.140 12.068
ENSG00000099991 E003 6.3593497 0.0814985170 1.242574e-01 3.224597e-01 22 24011315 24011340 26 + 1.007 0.750 -0.987
ENSG00000099991 E004 8.8757876 0.0662426554 4.188026e-02 1.596389e-01 22 24011341 24011347 7 + 1.162 0.852 -1.146
ENSG00000099991 E005 38.6224477 0.0042065382 1.353188e-06 3.697547e-05 22 24011348 24011367 20 + 1.754 1.441 -1.067
ENSG00000099991 E006 9.1145895 0.0044846877 1.691285e-01 3.894218e-01 22 24011368 24011415 48 + 0.807 0.985 0.678
ENSG00000099991 E007 10.1874504 0.0127005438 1.570564e-01 3.723494e-01 22 24011416 24011417 2 + 0.842 1.028 0.699
ENSG00000099991 E008 19.5448561 0.0019423588 7.710659e-01 8.793135e-01 22 24011418 24011439 22 + 1.237 1.262 0.091
ENSG00000099991 E009 137.0157472 0.0007533827 4.635820e-02 1.709447e-01 22 24011440 24011728 289 + 2.138 2.066 -0.239
ENSG00000099991 E010 186.5575058 0.0008153702 1.116209e-09 6.465144e-08 22 24035444 24035520 77 + 2.348 2.161 -0.624
ENSG00000099991 E011 223.2015722 0.0003029463 8.243747e-16 1.401379e-13 22 24036089 24036181 93 + 2.439 2.230 -0.699
ENSG00000099991 E012 221.3917584 0.0010163705 2.047423e-07 7.037028e-06 22 24038348 24038461 114 + 2.400 2.244 -0.518
ENSG00000099991 E013 161.4453468 0.0007372778 5.336072e-07 1.639269e-05 22 24041139 24041273 135 + 2.271 2.109 -0.542
ENSG00000099991 E014 242.5228895 0.0002207000 4.468671e-07 1.402223e-05 22 24042904 24043084 181 + 2.421 2.294 -0.424
ENSG00000099991 E015 251.6835500 0.0009539437 2.501728e-09 1.347518e-07 22 24049091 24049220 130 + 2.463 2.295 -0.562
ENSG00000099991 E016 286.2712197 0.0022432838 2.467776e-05 4.565696e-04 22 24050825 24050974 150 + 2.500 2.360 -0.465
ENSG00000099991 E017 357.9326098 0.0015186884 1.490152e-10 1.019305e-08 22 24054873 24055067 195 + 2.623 2.445 -0.592
ENSG00000099991 E018 247.9811193 0.0003235330 8.311287e-16 1.408630e-13 22 24055068 24055159 92 + 2.480 2.279 -0.670
ENSG00000099991 E019 301.1019972 0.0002302125 7.648548e-16 1.309374e-13 22 24056192 24056360 169 + 2.552 2.371 -0.604
ENSG00000099991 E020 0.4868358 0.2518111351 1.923372e-01   22 24056361 24056525 165 + 0.322 0.075 -2.541
ENSG00000099991 E021 223.6413060 0.0002288691 4.407875e-11 3.362797e-09 22 24059227 24059363 137 + 2.416 2.245 -0.568
ENSG00000099991 E022 337.6475254 0.0001600112 2.167429e-10 1.431658e-08 22 24059924 24060141 218 + 2.571 2.437 -0.448
ENSG00000099991 E023 192.3027624 0.0002557839 1.668123e-02 8.429156e-02 22 24061947 24062025 79 + 2.281 2.213 -0.229
ENSG00000099991 E024 265.8945307 0.0002563830 2.332946e-03 1.926984e-02 22 24062959 24063146 188 + 2.428 2.353 -0.249
ENSG00000099991 E025 266.2866674 0.0002218347 1.823952e-02 8.981834e-02 22 24064035 24064187 153 + 2.415 2.358 -0.193
ENSG00000099991 E026 134.1910288 0.0003130707 4.192796e-03 3.022597e-02 22 24066987 24067004 18 + 2.145 2.048 -0.325
ENSG00000099991 E027 266.7091270 0.0002169093 2.588224e-01 4.976675e-01 22 24067005 24067181 177 + 2.392 2.365 -0.093
ENSG00000099991 E028 184.6645690 0.0002408137 2.561759e-01 4.949493e-01 22 24070800 24070890 91 + 2.240 2.207 -0.110
ENSG00000099991 E029 240.5117198 0.0015627513 1.888921e-02 9.205184e-02 22 24070891 24071042 152 + 2.381 2.309 -0.240
ENSG00000099991 E030 0.5283420 0.3852486967 2.510292e-01   22 24071043 24071183 141 + 0.324 0.077 -2.514
ENSG00000099991 E031 282.9467755 0.0001799483 5.100565e-04 5.770006e-03 22 24072354 24072510 157 + 2.458 2.376 -0.272
ENSG00000099991 E032 237.6856407 0.0002078810 4.409985e-06 1.032989e-04 22 24076169 24076284 116 + 2.407 2.291 -0.388
ENSG00000099991 E033 300.8097581 0.0008004888 1.612242e-03 1.441334e-02 22 24083228 24083389 162 + 2.484 2.400 -0.282
ENSG00000099991 E034 395.2220948 0.0005476743 8.799136e-01 9.412007e-01 22 24084579 24084785 207 + 2.545 2.540 -0.019
ENSG00000099991 E035 279.8351748 0.0002494555 1.778350e-02 8.830854e-02 22 24085006 24085151 146 + 2.348 2.408 0.198
ENSG00000099991 E036 291.5812319 0.0001990306 4.300084e-01 6.510874e-01 22 24087452 24087587 136 + 2.398 2.417 0.065
ENSG00000099991 E037 280.3630827 0.0001879799 8.010175e-01 8.968718e-01 22 24087588 24087713 126 + 2.398 2.392 -0.021
ENSG00000099991 E038 404.9168361 0.0001953636 5.808173e-01 7.577079e-01 22 24091583 24091843 261 + 2.563 2.552 -0.039
ENSG00000099991 E039 6.0796627 0.0547988992 7.845560e-01 8.872676e-01 22 24091844 24092013 170 + 0.770 0.823 0.206
ENSG00000099991 E040 294.8975353 0.0002624571 5.391997e-01 7.284243e-01 22 24095931 24096082 152 + 2.407 2.422 0.050
ENSG00000099991 E041 257.0971710 0.0002787728 2.004176e-01 4.302574e-01 22 24098014 24098105 92 + 2.333 2.367 0.113
ENSG00000099991 E042 139.5166239 0.0003015714 2.269741e-01 4.617426e-01 22 24098106 24098112 7 + 2.124 2.084 -0.136
ENSG00000099991 E043 241.5457406 0.0001958972 9.163787e-01 9.604037e-01 22 24098113 24098192 80 + 2.332 2.330 -0.008
ENSG00000099991 E044 1.9814909 0.0122735898 3.602333e-01 5.958865e-01 22 24098193 24098282 90 + 0.319 0.493 0.962
ENSG00000099991 E045 389.7888924 0.0001814891 3.387131e-01 5.768637e-01 22 24113566 24113748 183 + 2.522 2.542 0.066
ENSG00000099991 E046 489.4898817 0.0001590298 1.298036e-03 1.214994e-02 22 24119367 24119698 332 + 2.590 2.651 0.204
ENSG00000099991 E047 292.4689063 0.0011577853 3.953327e-03 2.888713e-02 22 24134302 24134415 114 + 2.349 2.434 0.282
ENSG00000099991 E048 1.0726733 0.2312556317 1.796704e-01   22 24155838 24156076 239 + 0.000 0.339 13.102
ENSG00000099991 E049 0.5059767 0.0217071521 3.970198e-01   22 24156533 24156576 44 + 0.000 0.198 13.363
ENSG00000099991 E050 1.4099749 0.4652578412 5.156125e-01 7.120361e-01 22 24160330 24160406 77 + 0.186 0.386 1.423
ENSG00000099991 E051 1.0534597 0.0546963862 1.177435e-01   22 24162066 24162215 150 + 0.000 0.335 13.860
ENSG00000099991 E052 330.9238146 0.0032177374 1.341157e-02 7.207212e-02 22 24164400 24164563 164 + 2.396 2.487 0.303
ENSG00000099991 E053 226.6502237 0.0006567448 2.451522e-05 4.542828e-04 22 24165530 24165626 97 + 2.203 2.331 0.428
ENSG00000099991 E054 619.9776087 0.0001610628 5.989628e-07 1.816387e-05 22 24166639 24167222 584 + 2.672 2.759 0.287
ENSG00000099991 E055 256.6978875 0.0002596253 1.329967e-08 6.064957e-07 22 24167223 24167313 91 + 2.237 2.392 0.518
ENSG00000099991 E056 272.1951778 0.0016384485 6.652028e-06 1.474377e-04 22 24168447 24168521 75 + 2.269 2.414 0.484
ENSG00000099991 E057 601.2381855 0.0002918731 1.722952e-13 2.048998e-11 22 24171713 24171995 283 + 2.619 2.757 0.459
ENSG00000099991 E058 31.1666768 0.0556934039 8.339508e-01 9.160022e-01 22 24173077 24173398 322 + 1.434 1.457 0.082
ENSG00000099991 E059 55.3028907 0.0509630940 1.328594e-01 3.363038e-01 22 24175779 24176110 332 + 1.544 1.736 0.653
ENSG00000099991 E060 420.2601542 0.0002026177 8.597928e-17 1.657351e-14 22 24176111 24176275 165 + 2.430 2.611 0.603
ENSG00000099991 E061 266.7239789 0.0002181554 7.059293e-14 9.054609e-12 22 24177504 24177590 87 + 2.216 2.419 0.678
ENSG00000099991 E062 546.0244972 0.0001201371 4.073524e-23 1.712322e-20 22 24177591 24177817 227 + 2.540 2.725 0.618
ENSG00000099991 E063 220.0006386 0.0016792419 1.323641e-08 6.040974e-07 22 24178053 24178056 4 + 2.133 2.331 0.661
ENSG00000099991 E064 823.6201332 0.0001660276 5.152789e-40 8.579039e-37 22 24178057 24178628 572 + 2.696 2.908 0.704