ENSG00000099889

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263207 ENSG00000099889 HEK293_OSMI2_6hA HEK293_TMG_6hB ARVCF protein_coding protein_coding 10.33859 18.6599 5.285032 1.575853 0.3134089 -1.818003 0.6596958 1.2895314 0.6170613 0.3970380 0.04061016 -1.051313 0.06273333 0.07340000 0.11710000 0.04370000 7.008834e-01 4.038034e-07 FALSE TRUE
ENST00000406259 ENSG00000099889 HEK293_OSMI2_6hA HEK293_TMG_6hB ARVCF protein_coding protein_coding 10.33859 18.6599 5.285032 1.575853 0.3134089 -1.818003 0.2288755 0.6623124 0.8159931 0.6623124 0.41944096 0.296998 0.03016667 0.03933333 0.14833333 0.10900000 5.633292e-01 4.038034e-07 FALSE TRUE
ENST00000406522 ENSG00000099889 HEK293_OSMI2_6hA HEK293_TMG_6hB ARVCF protein_coding protein_coding 10.33859 18.6599 5.285032 1.575853 0.3134089 -1.818003 0.9930273 1.8777055 0.1528684 0.9626098 0.15286839 -3.534855 0.10211667 0.09863333 0.03033333 -0.06830000 7.502617e-01 4.038034e-07 FALSE TRUE
ENST00000473551 ENSG00000099889 HEK293_OSMI2_6hA HEK293_TMG_6hB ARVCF protein_coding retained_intron 10.33859 18.6599 5.285032 1.575853 0.3134089 -1.818003 1.1059595 1.6996450 0.8220878 0.5144348 0.14457173 -1.038889 0.11442083 0.09270000 0.15823333 0.06553333 6.279928e-01 4.038034e-07 FALSE TRUE
ENST00000495096 ENSG00000099889 HEK293_OSMI2_6hA HEK293_TMG_6hB ARVCF protein_coding retained_intron 10.33859 18.6599 5.285032 1.575853 0.3134089 -1.818003 2.7501753 4.5855435 1.4134040 0.4479538 0.39700842 -1.690890 0.26253333 0.24893333 0.26486667 0.01593333 1.000000e+00 4.038034e-07 FALSE TRUE
MSTRG.21649.2 ENSG00000099889 HEK293_OSMI2_6hA HEK293_TMG_6hB ARVCF protein_coding   10.33859 18.6599 5.285032 1.575853 0.3134089 -1.818003 2.0109408 3.6022656 0.0000000 1.3644188 0.00000000 -8.496760 0.18492917 0.18416667 0.00000000 -0.18416667 4.038034e-07 4.038034e-07 FALSE TRUE
MSTRG.21649.4 ENSG00000099889 HEK293_OSMI2_6hA HEK293_TMG_6hB ARVCF protein_coding   10.33859 18.6599 5.285032 1.575853 0.3134089 -1.818003 0.3226241 0.0000000 0.3112231 0.0000000 0.15614263 5.005504 0.03707083 0.00000000 0.06263333 0.06263333 1.438716e-01 4.038034e-07 FALSE TRUE
MSTRG.21649.5 ENSG00000099889 HEK293_OSMI2_6hA HEK293_TMG_6hB ARVCF protein_coding   10.33859 18.6599 5.285032 1.575853 0.3134089 -1.818003 1.3188261 2.9054298 0.8286344 1.2390291 0.49169168 -1.797595 0.11525000 0.15806667 0.15986667 0.00180000 9.689260e-01 4.038034e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000099889 E001 0.7198573 0.2951584019 0.58773006   22 19969896 19969897 2 - 0.001 0.205 8.239
ENSG00000099889 E002 40.1054737 0.0017132325 0.08356336 0.25189898 22 19969898 19970061 164 - 1.389 1.520 0.451
ENSG00000099889 E003 114.3140690 0.0004622486 0.07278704 0.23037336 22 19970062 19970367 306 - 1.875 1.951 0.257
ENSG00000099889 E004 101.8832269 0.0014792188 0.76986660 0.87857117 22 19970368 19970743 376 - 1.907 1.890 -0.056
ENSG00000099889 E005 13.1809734 0.0026729245 0.97449048 0.98910117 22 19971216 19971227 12 - 1.040 1.033 -0.025
ENSG00000099889 E006 23.6532396 0.0015481092 0.32776655 0.56683148 22 19971228 19971335 108 - 1.349 1.261 -0.309
ENSG00000099889 E007 78.0070923 0.0005518110 0.14820790 0.35975400 22 19971886 19971971 86 - 1.841 1.766 -0.251
ENSG00000099889 E008 67.5892127 0.0006566649 0.21605908 0.44869917 22 19972358 19972411 54 - 1.773 1.704 -0.236
ENSG00000099889 E009 87.0281356 0.0006614267 0.29477952 0.53530739 22 19972737 19972827 91 - 1.871 1.818 -0.178
ENSG00000099889 E010 87.6211311 0.0015596366 0.30641168 0.54705538 22 19972925 19973036 112 - 1.789 1.839 0.171
ENSG00000099889 E011 44.6888436 0.0092498773 0.35064534 0.58781137 22 19973119 19973161 43 - 1.479 1.558 0.271
ENSG00000099889 E012 84.2744368 0.0018482470 0.47662062 0.68472238 22 19973162 19973317 156 - 1.783 1.818 0.117
ENSG00000099889 E013 112.0216820 0.0004911041 0.53558484 0.72601392 22 19973643 19973793 151 - 1.911 1.934 0.079
ENSG00000099889 E014 94.8161054 0.0014634141 0.25067898 0.48871925 22 19974112 19974239 128 - 1.813 1.866 0.178
ENSG00000099889 E015 1.9625900 0.0376037838 0.20768814 0.43905167 22 19974240 19974278 39 - 0.584 0.337 -1.272
ENSG00000099889 E016 78.9888674 0.0044330845 0.99335287 0.99833920 22 19975686 19975757 72 - 1.784 1.776 -0.026
ENSG00000099889 E017 2.1066297 0.0170440473 0.60166952 0.77122853 22 19975758 19975762 5 - 0.496 0.392 -0.542
ENSG00000099889 E018 1.8277777 0.0114500737 0.13451601 0.33890025 22 19976706 19976723 18 - 0.585 0.306 -1.474
ENSG00000099889 E019 91.0501734 0.0024389908 0.25306261 0.49131709 22 19977415 19977586 172 - 1.794 1.851 0.192
ENSG00000099889 E020 79.1869246 0.0027621019 0.20631351 0.43734644 22 19977958 19978075 118 - 1.841 1.765 -0.256
ENSG00000099889 E021 99.5171574 0.0005888287 0.01292466 0.07014725 22 19978897 19979080 184 - 1.971 1.858 -0.378
ENSG00000099889 E022 21.0124915 0.0844270789 0.78115916 0.88538342 22 19979081 19979416 336 - 1.162 1.234 0.257
ENSG00000099889 E023 96.8700621 0.0036291061 0.56771783 0.74858553 22 19979743 19979996 254 - 1.846 1.869 0.080
ENSG00000099889 E024 85.6019424 0.0005984356 0.00759826 0.04747284 22 19979997 19980242 246 - 1.700 1.839 0.470
ENSG00000099889 E025 44.0566874 0.1078419637 0.11393693 0.30566834 22 19980243 19981151 909 - 1.719 1.479 -0.818
ENSG00000099889 E026 9.1107369 0.0437693894 0.23540312 0.47132523 22 19981152 19981210 59 - 1.042 0.859 -0.687
ENSG00000099889 E027 94.4638233 0.0006227236 0.48714082 0.69200674 22 19981211 19981381 171 - 1.836 1.867 0.104
ENSG00000099889 E028 76.2337668 0.0075624035 0.71301651 0.84367385 22 19981382 19981544 163 - 1.748 1.769 0.071
ENSG00000099889 E029 75.8208990 0.0025589521 0.38734833 0.61838454 22 19981545 19981737 193 - 1.809 1.759 -0.167
ENSG00000099889 E030 51.1726378 0.0009272176 0.58758036 0.76204724 22 19981933 19981990 58 - 1.633 1.597 -0.123
ENSG00000099889 E031 57.1567078 0.0022814725 0.55962435 0.74301708 22 19981991 19982091 101 - 1.681 1.642 -0.130
ENSG00000099889 E032 3.7420165 0.0070372527 0.96049284 0.98209786 22 19983673 19983753 81 - 0.585 0.593 0.036
ENSG00000099889 E033 1.5464525 0.0661790873 0.73314844 0.85611368 22 19986651 19986683 33 - 0.384 0.309 -0.459
ENSG00000099889 E034 8.5276839 0.0039006359 0.46938674 0.67959712 22 19987073 19987190 118 - 0.777 0.880 0.403
ENSG00000099889 E035 40.4920409 0.0008649522 0.44603648 0.66275781 22 19990585 19990812 228 - 1.546 1.491 -0.190
ENSG00000099889 E036 15.5400097 0.0139612894 0.75883118 0.87183915 22 20010455 20010508 54 - 1.141 1.107 -0.119
ENSG00000099889 E037 15.0649746 0.0090063973 0.08695795 0.25815884 22 20016589 20016823 235 - 0.909 1.133 0.822