ENSG00000099814

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000251181 ENSG00000099814 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP170B protein_coding retained_intron 20.49289 31.90671 10.60282 4.476253 0.3767878 -1.588503 4.775757 6.1569330 1.040175 0.8929652 0.08464764 -2.5539231 0.19135833 0.19330000 0.0986000 -0.094700000 0.01258071 0.01258071 FALSE TRUE
ENST00000556508 ENSG00000099814 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP170B protein_coding protein_coding 20.49289 31.90671 10.60282 4.476253 0.3767878 -1.588503 3.209382 4.9064634 1.644613 1.4152999 0.58034565 -1.5711273 0.16187083 0.14850000 0.1528667 0.004366667 1.00000000 0.01258071 FALSE TRUE
MSTRG.10268.3 ENSG00000099814 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP170B protein_coding   20.49289 31.90671 10.60282 4.476253 0.3767878 -1.588503 9.126534 15.9211771 5.501582 2.4589694 0.65245773 -1.5313145 0.46660833 0.50020000 0.5225333 0.022333333 0.97907559 0.01258071 FALSE TRUE
MSTRG.10268.5 ENSG00000099814 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP170B protein_coding   20.49289 31.90671 10.60282 4.476253 0.3767878 -1.588503 1.842672 3.2007577 1.007474 0.3388260 0.50903569 -1.6579214 0.09399583 0.10780000 0.0926000 -0.015200000 0.91627000 0.01258071 FALSE TRUE
MSTRG.10268.6 ENSG00000099814 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP170B protein_coding   20.49289 31.90671 10.60282 4.476253 0.3767878 -1.588503 0.987229 0.7845899 1.040956 0.4643200 0.14890331 0.4034197 0.05464167 0.02393333 0.0977000 0.073766667 0.44935178 0.01258071 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000099814 E001 0.3336024 0.0244411696 1.000000e+00   14 104865268 104865279 12 + 0.000 0.133 10.488
ENSG00000099814 E002 0.3336024 0.0244411696 1.000000e+00   14 104865280 104865291 12 + 0.000 0.133 10.485
ENSG00000099814 E003 1.1787910 0.0801007996 7.352020e-01   14 104865292 104865367 76 + 0.200 0.317 0.878
ENSG00000099814 E004 2.0351259 0.0307049033 7.710473e-01 8.793041e-01 14 104865368 104865415 48 + 0.336 0.446 0.618
ENSG00000099814 E005 5.1192582 0.0056781220 8.519348e-02 2.549799e-01 14 104865416 104865425 10 + 0.869 0.692 -0.707
ENSG00000099814 E006 47.2821041 0.0013514381 8.349775e-02 2.517682e-01 14 104865426 104865513 88 + 1.633 1.605 -0.092
ENSG00000099814 E007 4.9376719 0.0076894604 2.760669e-04 3.489321e-03 14 104866856 104867007 152 + 1.013 0.585 -1.708
ENSG00000099814 E008 80.4527496 0.0163745829 1.854865e-02 9.089035e-02 14 104868424 104868555 132 + 1.906 1.815 -0.307
ENSG00000099814 E009 107.0323731 0.0023540764 1.139443e-07 4.169438e-06 14 104876256 104876345 90 + 2.074 1.922 -0.509
ENSG00000099814 E010 103.6755843 0.0131924869 5.058893e-04 5.733559e-03 14 104877885 104877963 79 + 2.052 1.911 -0.472
ENSG00000099814 E011 103.2760265 0.0043802489 2.552187e-04 3.276287e-03 14 104878443 104878501 59 + 2.021 1.923 -0.331
ENSG00000099814 E012 142.4117970 0.0007231028 3.010819e-03 2.346518e-02 14 104880287 104880425 139 + 2.112 2.085 -0.090
ENSG00000099814 E013 89.9653307 0.4991850285 5.143967e-01 7.112646e-01 14 104882728 104882832 105 + 1.812 1.906 0.314
ENSG00000099814 E014 191.5680466 1.0512554336 6.491092e-01 8.029232e-01 14 104883035 104883508 474 + 2.187 2.217 0.103
ENSG00000099814 E015 284.1657365 1.1602099678 5.817140e-01 7.582164e-01 14 104883831 104884549 719 + 2.307 2.401 0.314
ENSG00000099814 E016 3.7378302 0.1020485889 4.224216e-01 6.454215e-01 14 104884550 104884566 17 + 0.702 0.590 -0.479
ENSG00000099814 E017 142.6360049 0.0660250132 4.226659e-01 6.456459e-01 14 104885369 104885542 174 + 1.993 2.108 0.387
ENSG00000099814 E018 93.6090732 0.0014588972 1.084610e-02 6.171043e-02 14 104886040 104886130 91 + 1.741 1.946 0.691
ENSG00000099814 E019 182.3440413 0.8894028750 4.161152e-01 6.406877e-01 14 104886275 104886583 309 + 2.022 2.229 0.691
ENSG00000099814 E020 199.3538355 0.9441229004 4.485393e-01 6.646390e-01 14 104886584 104886918 335 + 2.078 2.264 0.623
ENSG00000099814 E021 588.0819869 1.3352413279 4.455554e-01 6.624662e-01 14 104886919 104887978 1060 + 2.502 2.740 0.795
ENSG00000099814 E022 170.0774647 0.8019925076 3.318654e-01 5.706992e-01 14 104889515 104889619 105 + 1.936 2.209 0.913
ENSG00000099814 E023 204.3942721 0.8980000617 3.695335e-01 6.036716e-01 14 104889620 104889758 139 + 2.031 2.285 0.851
ENSG00000099814 E024 244.6313080 0.0002010968 7.999486e-01 8.963224e-01 14 104892976 104893135 160 + 2.255 2.342 0.292
ENSG00000099814 E025 270.6493845 0.0116871885 1.904230e-01 4.174933e-01 14 104893523 104893666 144 + 2.347 2.364 0.056
ENSG00000099814 E026 229.0084813 0.0450221516 3.245832e-01 5.638578e-01 14 104893761 104893849 89 + 2.295 2.285 -0.032
ENSG00000099814 E027 15.7659000 0.1429886046 2.577912e-01 4.965731e-01 14 104893934 104894284 351 + 1.226 1.130 -0.344
ENSG00000099814 E028 255.7464287 0.0479115493 3.924268e-01 6.223223e-01 14 104894285 104894378 94 + 2.334 2.336 0.006
ENSG00000099814 E029 192.6845158 0.0495572926 6.364898e-01 7.946650e-01 14 104894537 104894588 52 + 2.181 2.222 0.136
ENSG00000099814 E030 1307.1605603 0.0553208867 8.227009e-01 9.095401e-01 14 104894711 104896747 2037 + 2.975 3.061 0.286