ENSG00000099783

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000325495 ENSG00000099783 HEK293_OSMI2_6hA HEK293_TMG_6hB HNRNPM protein_coding protein_coding 356.9644 456.3339 347.4085 115.6461 13.87651 -0.3934468 247.924009 311.43441 226.049880 80.841438 7.872248 -0.4622697 0.692991667 0.67903333 0.65163333 -0.02740000 8.383990e-01 6.104717e-47 FALSE TRUE
ENST00000348943 ENSG00000099783 HEK293_OSMI2_6hA HEK293_TMG_6hB HNRNPM protein_coding protein_coding 356.9644 456.3339 347.4085 115.6461 13.87651 -0.3934468 21.637455 50.33687 0.000000 15.867922 0.000000 -12.2976863 0.051945833 0.10470000 0.00000000 -0.10470000 6.104717e-47 6.104717e-47 FALSE TRUE
ENST00000597270 ENSG00000099783 HEK293_OSMI2_6hA HEK293_TMG_6hB HNRNPM protein_coding protein_coding 356.9644 456.3339 347.4085 115.6461 13.87651 -0.3934468 20.027053 45.44547 7.274013 13.212302 4.200057 -2.6416483 0.052491667 0.09656667 0.02143333 -0.07513333 6.027849e-01 6.104717e-47 FALSE TRUE
ENST00000598367 ENSG00000099783 HEK293_OSMI2_6hA HEK293_TMG_6hB HNRNPM protein_coding protein_coding 356.9644 456.3339 347.4085 115.6461 13.87651 -0.3934468 3.048463 0.00000 20.648952 0.000000 13.348196 11.0125513 0.008579167 0.00000000 0.05783333 0.05783333 2.766111e-01 6.104717e-47   FALSE
ENST00000600092 ENSG00000099783 HEK293_OSMI2_6hA HEK293_TMG_6hB HNRNPM protein_coding protein_coding 356.9644 456.3339 347.4085 115.6461 13.87651 -0.3934468 45.893500 40.29429 72.291226 6.521032 2.979304 0.8430867 0.137633333 0.09496667 0.20863333 0.11366667 1.932323e-03 6.104717e-47 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000099783 E001 0.000000       19 8444487 8444586 100 +      
ENSG00000099783 E002 0.000000       19 8444587 8444766 180 +      
ENSG00000099783 E003 5.044820 5.866609e-03 5.714732e-04 6.322430e-03 19 8444767 8444919 153 + 0.340 0.923 2.637
ENSG00000099783 E004 35.444217 2.952396e-01 4.404556e-02 1.652297e-01 19 8444920 8444970 51 + 1.205 1.686 1.662
ENSG00000099783 E005 39.345034 3.859408e-01 1.236082e-01 3.214430e-01 19 8444971 8444974 4 + 1.327 1.711 1.320
ENSG00000099783 E006 40.893842 4.177600e-01 1.547722e-01 3.690675e-01 19 8444975 8444976 2 + 1.363 1.722 1.229
ENSG00000099783 E007 262.571979 1.495925e+00 6.529192e-01 8.053391e-01 19 8444977 8444989 13 + 2.381 2.429 0.159
ENSG00000099783 E008 298.200410 1.527721e+00 6.405763e-01 7.972872e-01 19 8444990 8444991 2 + 2.425 2.491 0.219
ENSG00000099783 E009 313.358210 1.544051e+00 6.406025e-01 7.973106e-01 19 8444992 8444992 1 + 2.446 2.512 0.220
ENSG00000099783 E010 362.180479 1.576521e+00 6.155695e-01 7.807043e-01 19 8444993 8444993 1 + 2.490 2.585 0.317
ENSG00000099783 E011 1258.149436 1.918982e+00 5.940482e-01 7.663730e-01 19 8444994 8445111 118 + 2.981 3.149 0.559
ENSG00000099783 E012 3147.861110 9.502376e-03 3.557691e-01 5.923434e-01 19 8455405 8455574 170 + 3.494 3.485 -0.029
ENSG00000099783 E013 24.902543 5.367790e-02 3.714361e-01 6.051020e-01 19 8461969 8462528 560 + 1.457 1.359 -0.337
ENSG00000099783 E014 2400.316639 1.220302e-04 7.099775e-31 6.183103e-28 19 8462529 8462581 53 + 3.407 3.348 -0.197
ENSG00000099783 E015 6.681288 1.887886e-02 8.348529e-01 9.164333e-01 19 8462582 8462589 8 + 0.864 0.868 0.015
ENSG00000099783 E016 1477.144232 7.501580e-05 2.655974e-25 1.392116e-22 19 8463497 8463500 4 + 3.197 3.137 -0.199
ENSG00000099783 E017 1567.348205 7.459776e-05 2.691977e-26 1.544458e-23 19 8463501 8463504 4 + 3.222 3.163 -0.198
ENSG00000099783 E018 2136.039980 2.164382e-04 2.148207e-17 4.470772e-15 19 8463593 8463638 46 + 3.348 3.302 -0.150
ENSG00000099783 E019 2365.363402 2.862031e-04 2.723837e-10 1.759491e-08 19 8463639 8463686 48 + 3.380 3.355 -0.086
ENSG00000099783 E020 7.321954 9.782765e-03 8.491129e-01 9.244358e-01 19 8463687 8463852 166 + 0.865 0.924 0.225
ENSG00000099783 E021 2106.210951 5.117108e-04 3.488682e-05 6.138193e-04 19 8465324 8465362 39 + 3.321 3.309 -0.040
ENSG00000099783 E022 2086.220961 2.842384e-04 9.393588e-08 3.507580e-06 19 8465363 8465479 117 + 3.319 3.304 -0.050
ENSG00000099783 E023 2214.687615 8.257844e-04 4.408405e-04 5.133412e-03 19 8465480 8465515 36 + 3.341 3.332 -0.030
ENSG00000099783 E024 1744.875261 7.779761e-04 1.580978e-02 8.112354e-02 19 8466235 8466248 14 + 3.227 3.235 0.025
ENSG00000099783 E025 3408.243518 6.159718e-04 6.157914e-04 6.717771e-03 19 8466249 8466388 140 + 3.523 3.523 0.002
ENSG00000099783 E026 2006.829023 1.075017e-03 2.436176e-03 1.992097e-02 19 8467535 8467584 50 + 3.297 3.290 -0.025
ENSG00000099783 E027 1953.253747 9.006448e-04 2.567543e-03 2.076818e-02 19 8468774 8468815 42 + 3.284 3.279 -0.015
ENSG00000099783 E028 1554.486170 5.615402e-04 4.773183e-03 3.338961e-02 19 8468816 8468834 19 + 3.179 3.183 0.013
ENSG00000099783 E029 2737.571896 3.761700e-04 1.265310e-05 2.573125e-04 19 8471326 8471427 102 + 3.432 3.425 -0.023
ENSG00000099783 E030 2408.325451 2.906785e-04 1.794437e-05 3.485095e-04 19 8473664 8473708 45 + 3.375 3.371 -0.012
ENSG00000099783 E031 2624.121391 6.018082e-04 9.784624e-01 9.910148e-01 19 8474167 8474244 78 + 3.384 3.426 0.141
ENSG00000099783 E032 4.927870 1.329855e-01 3.079594e-02 1.297362e-01 19 8481469 8481556 88 + 0.411 0.891 2.107
ENSG00000099783 E033 17.587716 1.401035e-01 9.826243e-02 2.787289e-01 19 8482549 8483157 609 + 1.002 1.369 1.307
ENSG00000099783 E034 1499.456158 1.341419e-03 9.284768e-02 2.690224e-01 19 8483158 8483211 54 + 3.121 3.195 0.246
ENSG00000099783 E035 2849.606285 3.929879e-03 4.205168e-07 1.331595e-05 19 8485603 8485861 259 + 3.312 3.514 0.672
ENSG00000099783 E036 2894.731256 5.998209e-03 9.765699e-10 5.714818e-08 19 8485862 8486157 296 + 3.261 3.542 0.933
ENSG00000099783 E037 3198.306467 3.137693e-03 5.377239e-09 2.679516e-07 19 8486158 8486405 248 + 3.357 3.566 0.696
ENSG00000099783 E038 2146.676627 7.647400e-04 3.874927e-04 4.609733e-03 19 8487024 8487075 52 + 3.259 3.360 0.334
ENSG00000099783 E039 12.707462 1.034875e-01 1.332307e-01 3.368781e-01 19 8487076 8487184 109 + 0.931 1.220 1.047
ENSG00000099783 E040 31.051033 2.206106e-01 3.569060e-01 5.932179e-01 19 8487302 8488008 707 + 1.280 1.595 1.087
ENSG00000099783 E041 12.609538 1.493878e-01 2.387404e-01 4.751668e-01 19 8488009 8488066 58 + 0.931 1.213 1.025
ENSG00000099783 E042 46.828670 1.596513e-01 2.670346e-01 5.066337e-01 19 8488067 8488690 624 + 1.479 1.759 0.956
ENSG00000099783 E043 4296.834741 7.976993e-04 4.840435e-05 8.089127e-04 19 8488691 8489114 424 + 3.556 3.662 0.351