ENSG00000099331

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000397274 ENSG00000099331 HEK293_OSMI2_6hA HEK293_TMG_6hB MYO9B protein_coding protein_coding 16.61633 24.57824 9.943574 2.261245 0.123989 -1.304682 2.19505677 3.8854570 1.6533640 1.1809807 0.83896410 -1.2276887 0.13418750 0.161033333 0.1682000 0.007166667 9.689850e-01 1.086575e-06 FALSE TRUE
ENST00000597073 ENSG00000099331 HEK293_OSMI2_6hA HEK293_TMG_6hB MYO9B protein_coding protein_coding 16.61633 24.57824 9.943574 2.261245 0.123989 -1.304682 2.48139091 3.0991177 0.0000000 1.5635293 0.00000000 -8.2803614 0.10659167 0.116166667 0.0000000 -0.116166667 3.996284e-01 1.086575e-06 FALSE TRUE
ENST00000599420 ENSG00000099331 HEK293_OSMI2_6hA HEK293_TMG_6hB MYO9B protein_coding retained_intron 16.61633 24.57824 9.943574 2.261245 0.123989 -1.304682 1.29339370 1.4394963 1.0489418 0.5298954 0.06239724 -0.4529284 0.08457917 0.063566667 0.1053667 0.041800000 6.088141e-01 1.086575e-06 FALSE FALSE
ENST00000682292 ENSG00000099331 HEK293_OSMI2_6hA HEK293_TMG_6hB MYO9B protein_coding protein_coding 16.61633 24.57824 9.943574 2.261245 0.123989 -1.304682 1.51761006 3.2890949 0.0000000 1.4107552 0.00000000 -8.3659265 0.08507917 0.129166667 0.0000000 -0.129166667 1.086575e-06 1.086575e-06 FALSE TRUE
MSTRG.16660.1 ENSG00000099331 HEK293_OSMI2_6hA HEK293_TMG_6hB MYO9B protein_coding   16.61633 24.57824 9.943574 2.261245 0.123989 -1.304682 2.62899203 3.8945836 1.5611157 0.1849277 0.50590303 -1.3133792 0.18127500 0.159933333 0.1558667 -0.004066667 9.683609e-01 1.086575e-06 FALSE TRUE
MSTRG.16660.10 ENSG00000099331 HEK293_OSMI2_6hA HEK293_TMG_6hB MYO9B protein_coding   16.61633 24.57824 9.943574 2.261245 0.123989 -1.304682 3.13728867 5.8426916 1.6215704 1.1024430 0.44101969 -1.8428390 0.16532083 0.234433333 0.1641667 -0.070266667 7.087504e-01 1.086575e-06 FALSE TRUE
MSTRG.16660.6 ENSG00000099331 HEK293_OSMI2_6hA HEK293_TMG_6hB MYO9B protein_coding   16.61633 24.57824 9.943574 2.261245 0.123989 -1.304682 0.33894484 0.1713558 1.1629204 0.1099836 0.58146018 2.6932104 0.02827917 0.007133333 0.1166333 0.109500000 6.281273e-01 1.086575e-06 FALSE TRUE
MSTRG.16660.8 ENSG00000099331 HEK293_OSMI2_6hA HEK293_TMG_6hB MYO9B protein_coding   16.61633 24.57824 9.943574 2.261245 0.123989 -1.304682 0.07253578 0.0000000 0.5802862 0.0000000 0.58028621 5.8833427 0.00712500 0.000000000 0.0570000 0.057000000 7.924022e-01 1.086575e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000099331 E001 0.0000000       19 17075759 17075761 3 +      
ENSG00000099331 E002 0.0000000       19 17075762 17075776 15 +      
ENSG00000099331 E003 0.0000000       19 17075777 17075780 4 +      
ENSG00000099331 E004 0.2735028 0.0255497753 3.575284e-01   19 17075781 17075785 5 + 0.200 0.071 -1.721
ENSG00000099331 E005 8.3832868 0.0043496182 2.122029e-01 4.443309e-01 19 17075786 17075874 89 + 0.755 0.953 0.770
ENSG00000099331 E006 0.1614157 0.0326473685 1.260457e-01   19 17098794 17098838 45 + 0.200 0.000 -12.602
ENSG00000099331 E007 0.1723744 0.0363206336 1.000000e+00   19 17101656 17101659 4 + 0.000 0.071 9.129
ENSG00000099331 E008 15.8446563 0.0090416364 7.027672e-01 8.373280e-01 19 17101660 17101717 58 + 1.104 1.176 0.257
ENSG00000099331 E009 102.6897393 0.0240863361 2.512131e-02 1.126056e-01 19 17101718 17102181 464 + 2.058 1.899 -0.531
ENSG00000099331 E010 124.4890562 0.0004872501 2.111733e-05 4.002018e-04 19 17102182 17102557 376 + 2.123 1.998 -0.418
ENSG00000099331 E011 7.4451047 0.0042903606 6.786285e-01 8.218435e-01 19 17103257 17103789 533 + 0.797 0.879 0.320
ENSG00000099331 E012 63.6073453 0.0372533150 4.082960e-01 6.346997e-01 19 17145397 17145491 95 + 1.803 1.719 -0.285
ENSG00000099331 E013 50.7951855 0.4918150449 7.724846e-01 8.801571e-01 19 17152644 17152706 63 + 1.700 1.621 -0.267
ENSG00000099331 E014 63.5958978 0.0060884130 1.749354e-03 1.536570e-02 19 17153967 17154066 100 + 1.862 1.694 -0.567
ENSG00000099331 E015 74.4451596 0.0081361114 7.240651e-04 7.643818e-03 19 17154315 17154415 101 + 1.932 1.757 -0.590
ENSG00000099331 E016 92.5486035 0.0269243526 1.045005e-02 6.007444e-02 19 17156909 17157038 130 + 2.039 1.844 -0.656
ENSG00000099331 E017 81.7271465 0.0132748914 2.076613e-03 1.757834e-02 19 17159395 17159484 90 + 1.976 1.797 -0.603
ENSG00000099331 E018 90.9226697 0.0004610773 4.313280e-07 1.359492e-05 19 17162350 17162466 117 + 2.024 1.846 -0.601
ENSG00000099331 E019 96.4941215 0.0079662449 1.165642e-02 6.505830e-02 19 17162988 17163122 135 + 2.010 1.883 -0.427
ENSG00000099331 E020 96.0650449 0.3110265012 7.804072e-01 8.850097e-01 19 17167943 17168064 122 + 1.959 1.898 -0.206
ENSG00000099331 E021 64.9658938 0.0186756517 9.344201e-02 2.700993e-01 19 17172336 17172374 39 + 1.841 1.716 -0.424
ENSG00000099331 E022 84.9976407 0.0128776973 1.256829e-01 3.249424e-01 19 17172375 17172477 103 + 1.923 1.843 -0.270
ENSG00000099331 E023 59.9889235 0.0135947793 1.912176e-01 4.183975e-01 19 17172759 17172812 54 + 1.766 1.695 -0.241
ENSG00000099331 E024 59.9976156 0.0138311780 6.199758e-01 7.837992e-01 19 17172813 17172923 111 + 1.717 1.709 -0.026
ENSG00000099331 E025 40.0151606 0.0105056873 7.694155e-01 8.782866e-01 19 17172924 17172963 40 + 1.498 1.548 0.173
ENSG00000099331 E026 53.7707727 0.0086717588 4.082149e-01 6.346285e-01 19 17175663 17175741 79 + 1.592 1.682 0.303
ENSG00000099331 E027 1.4630076 0.2477714993 8.962380e-01 9.498987e-01 19 17177797 17177886 90 + 0.339 0.351 0.071
ENSG00000099331 E028 1.2178395 1.2643330411 6.596395e-01   19 17180645 17180926 282 + 0.349 0.285 -0.410
ENSG00000099331 E029 70.0910251 0.0006071140 7.378328e-02 2.323314e-01 19 17180927 17181040 114 + 1.827 1.769 -0.197
ENSG00000099331 E030 0.3040503 0.0244411696 2.633227e-02   19 17183737 17183828 92 + 0.336 0.000 -13.601
ENSG00000099331 E031 53.5030686 0.0010477272 2.233185e-02 1.036956e-01 19 17183829 17183868 40 + 1.744 1.646 -0.330
ENSG00000099331 E032 2.1393564 0.4414092561 9.195712e-02 2.673314e-01 19 17183869 17184002 134 + 0.750 0.285 -2.314
ENSG00000099331 E033 4.4594838 0.2970463183 4.073624e-01 6.339766e-01 19 17184511 17184864 354 + 0.760 0.645 -0.476
ENSG00000099331 E034 87.5171119 0.0005009758 5.359285e-03 3.649278e-02 19 17184865 17184987 123 + 1.946 1.854 -0.307
ENSG00000099331 E035 72.6437637 0.0007577153 3.928739e-03 2.874829e-02 19 17185921 17186001 81 + 1.877 1.769 -0.365
ENSG00000099331 E036 78.9996680 0.0011202514 1.797119e-02 8.894587e-02 19 17187935 17188045 111 + 1.894 1.812 -0.275
ENSG00000099331 E037 77.3562539 0.0082435177 2.681456e-01 5.078035e-01 19 17191097 17191219 123 + 1.850 1.815 -0.119
ENSG00000099331 E038 150.1412546 0.0043735641 9.488151e-01 9.766079e-01 19 17192746 17193062 317 + 2.080 2.116 0.120
ENSG00000099331 E039 381.9845564 0.0113324146 9.884273e-01 9.959753e-01 19 17194556 17195473 918 + 2.481 2.516 0.118
ENSG00000099331 E040 83.6213199 0.0108610820 8.782029e-01 9.403896e-01 19 17197792 17197858 67 + 1.835 1.859 0.080
ENSG00000099331 E041 1.1071126 0.0148830860 6.882180e-01   19 17198118 17198183 66 + 0.337 0.276 -0.401
ENSG00000099331 E042 98.4246811 0.0011829568 8.970019e-01 9.503023e-01 19 17198184 17198308 125 + 1.906 1.930 0.080
ENSG00000099331 E043 103.1000633 0.0045522503 1.431072e-01 3.521394e-01 19 17200293 17200426 134 + 1.976 1.931 -0.152
ENSG00000099331 E044 166.2993208 0.0003933661 1.458000e-01 3.560646e-01 19 17200639 17200829 191 + 2.165 2.146 -0.063
ENSG00000099331 E045 155.0753885 0.0047140287 1.826475e-01 4.074841e-01 19 17201926 17202024 99 + 2.142 2.112 -0.100
ENSG00000099331 E046 0.0000000       19 17202129 17202129 1 +      
ENSG00000099331 E047 196.3135931 0.0046223683 1.513634e-01 3.643090e-01 19 17202130 17202303 174 + 2.243 2.213 -0.100
ENSG00000099331 E048 41.9312009 0.0059709776 7.394065e-01 8.600492e-01 19 17202842 17202844 3 + 1.558 1.558 0.000
ENSG00000099331 E049 91.3721999 0.0036052302 6.773920e-01 8.210681e-01 19 17202845 17202869 25 + 1.884 1.891 0.024
ENSG00000099331 E050 84.8529093 0.0027980106 6.628361e-01 8.116428e-01 19 17202870 17202883 14 + 1.853 1.859 0.021
ENSG00000099331 E051 10.8348948 0.1890213472 2.483064e-01 4.860880e-01 19 17202884 17203004 121 + 1.150 0.950 -0.730
ENSG00000099331 E052 10.3325092 0.1074891766 1.788184e-02 8.864982e-02 19 17203005 17203146 142 + 1.240 0.870 -1.353
ENSG00000099331 E053 134.0708866 0.0003169177 3.201467e-01 5.598834e-01 19 17203147 17203258 112 + 2.007 2.073 0.220
ENSG00000099331 E054 100.6778964 0.0007710441 5.009629e-01 7.014761e-01 19 17205263 17205336 74 + 1.894 1.952 0.196
ENSG00000099331 E055 139.1894160 0.0002965162 6.275113e-02 2.089305e-01 19 17205960 17206152 193 + 2.000 2.097 0.326
ENSG00000099331 E056 129.2562969 0.0003500572 2.003434e-03 1.709007e-02 19 17206248 17206376 129 + 1.925 2.075 0.504
ENSG00000099331 E057 61.2098622 0.0039001316 1.859521e-02 9.104758e-02 19 17206679 17206688 10 + 1.578 1.762 0.623
ENSG00000099331 E058 121.2704485 0.0004155643 5.984925e-07 1.815519e-05 19 17206689 17206773 85 + 1.823 2.063 0.807
ENSG00000099331 E059 74.5892836 0.0006313830 1.473816e-05 2.936961e-04 19 17206774 17206784 11 + 1.591 1.856 0.895
ENSG00000099331 E060 3.4446683 0.1880917039 5.970090e-01 7.683586e-01 19 17206785 17206828 44 + 0.444 0.615 0.809
ENSG00000099331 E061 130.6252422 0.2207401344 1.296402e-01 3.312603e-01 19 17207113 17207212 100 + 1.829 2.092 0.884
ENSG00000099331 E062 105.0002107 0.5293079091 2.817219e-01 5.220685e-01 19 17207213 17207244 32 + 1.773 1.992 0.738
ENSG00000099331 E063 143.3736389 0.0490965756 6.417922e-02 2.120959e-01 19 17209586 17209709 124 + 1.921 2.124 0.679
ENSG00000099331 E064 94.9315470 0.0076227589 2.372062e-01 4.733437e-01 19 17210333 17210380 48 + 1.829 1.929 0.337
ENSG00000099331 E065 4.3443306 0.3333385667 1.626158e-01 3.806517e-01 19 17210443 17210590 148 + 0.872 0.585 -1.180
ENSG00000099331 E066 3.9153815 0.2531537683 3.382495e-01 5.764719e-01 19 17210591 17210714 124 + 0.752 0.590 -0.686
ENSG00000099331 E067 137.3599500 0.0189986124 4.794592e-02 1.748817e-01 19 17210715 17210848 134 + 1.934 2.100 0.555
ENSG00000099331 E068 2.2321486 0.0089732762 2.556764e-01 4.943555e-01 19 17210849 17210852 4 + 0.594 0.415 -0.872
ENSG00000099331 E069 59.3103217 0.3962844249 3.979620e-01 6.267288e-01 19 17211647 17211650 4 + 1.610 1.731 0.414
ENSG00000099331 E070 89.0465906 0.4805850235 2.901855e-01 5.307855e-01 19 17211651 17211774 124 + 1.710 1.920 0.707
ENSG00000099331 E071 25.2146980 0.0084468804 1.997315e-03 1.704729e-02 19 17211775 17211786 12 + 1.061 1.407 1.220
ENSG00000099331 E072 29.5931115 0.0018662689 1.822773e-05 3.531243e-04 19 17211787 17211894 108 + 1.062 1.484 1.485
ENSG00000099331 E073 461.9274832 1.2496579966 3.257062e-01 5.649369e-01 19 17211895 17213295 1401 + 2.314 2.647 1.110
ENSG00000099331 E074 1.1901250 0.0318775532 7.003751e-01   19 17214460 17214594 135 + 0.337 0.277 -0.396