ENSG00000099246

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000375802 ENSG00000099246 HEK293_OSMI2_6hA HEK293_TMG_6hB RAB18 protein_coding protein_coding 22.23115 6.840685 39.92228 0.9656762 2.512699 2.543235 1.5730006 0.5192334 3.029181 0.5192334 0.8410543 2.521706 0.07069583 0.07523333 0.07810000 0.002866667 0.565419709 0.007695632 FALSE  
ENST00000682963 ENSG00000099246 HEK293_OSMI2_6hA HEK293_TMG_6hB RAB18 protein_coding protein_coding 22.23115 6.840685 39.92228 0.9656762 2.512699 2.543235 0.7608535 0.0000000 2.651910 0.0000000 1.2453488 8.056318 0.02373750 0.00000000 0.06300000 0.063000000 0.007695632 0.007695632    
ENST00000683042 ENSG00000099246 HEK293_OSMI2_6hA HEK293_TMG_6hB RAB18 protein_coding retained_intron 22.23115 6.840685 39.92228 0.9656762 2.512699 2.543235 4.8748674 1.1885969 9.818121 0.9096412 0.8543143 3.035569 0.23158333 0.15520000 0.25073333 0.095533333 0.770769128 0.007695632 TRUE  
ENST00000683446 ENSG00000099246 HEK293_OSMI2_6hA HEK293_TMG_6hB RAB18 protein_coding retained_intron 22.23115 6.840685 39.92228 0.9656762 2.512699 2.543235 1.0022047 0.4006959 0.000000 0.4006959 0.0000000 -5.359999 0.07341667 0.04723333 0.00000000 -0.047233333 0.643450446 0.007695632    
ENST00000683755 ENSG00000099246 HEK293_OSMI2_6hA HEK293_TMG_6hB RAB18 protein_coding protein_coding 22.23115 6.840685 39.92228 0.9656762 2.512699 2.543235 2.6001865 1.0112235 3.114757 0.1716753 1.8934184 1.613445 0.12877500 0.14646667 0.08483333 -0.061633333 0.793942762 0.007695632 FALSE  
ENST00000683797 ENSG00000099246 HEK293_OSMI2_6hA HEK293_TMG_6hB RAB18 protein_coding protein_coding 22.23115 6.840685 39.92228 0.9656762 2.512699 2.543235 6.8414121 2.0928041 14.065726 0.3003670 1.1974506 2.742823 0.28125417 0.30616667 0.35180000 0.045633333 0.715999067 0.007695632 FALSE  
ENST00000684501 ENSG00000099246 HEK293_OSMI2_6hA HEK293_TMG_6hB RAB18 protein_coding protein_coding 22.23115 6.840685 39.92228 0.9656762 2.512699 2.543235 3.2321601 1.2009533 5.406322 0.6021155 3.0099143 2.161170 0.11966250 0.20513333 0.12676667 -0.078366667 0.972233705 0.007695632 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000099246 E001 0.6129023 0.0190306359 0.774771311   10 27504174 27504233 60 + 0.169 0.219 0.466
ENSG00000099246 E002 1.0595873 0.0148250654 0.748351752   10 27504234 27504279 46 + 0.290 0.219 -0.532
ENSG00000099246 E003 1.0595873 0.0148250654 0.748351752   10 27504280 27504285 6 + 0.290 0.219 -0.532
ENSG00000099246 E004 1.0595873 0.0148250654 0.748351752   10 27504286 27504293 8 + 0.290 0.219 -0.532
ENSG00000099246 E005 1.2022220 0.0153787590 0.625054160   10 27504294 27504298 5 + 0.324 0.219 -0.754
ENSG00000099246 E006 1.3282884 0.1219300346 0.582804342   10 27504299 27504303 5 + 0.352 0.218 -0.938
ENSG00000099246 E007 3.3157871 0.0514546176 0.918311567 0.96136019 10 27504304 27504311 8 + 0.582 0.557 -0.116
ENSG00000099246 E008 3.4584217 0.0719073926 0.864898167 0.93308358 10 27504312 27504313 2 + 0.598 0.556 -0.192
ENSG00000099246 E009 10.3049241 0.0359750881 0.558876763 0.74244944 10 27504314 27504317 4 + 0.991 0.909 -0.308
ENSG00000099246 E010 22.5535004 0.0367321453 0.748399369 0.86573138 10 27504318 27504327 10 + 1.272 1.332 0.207
ENSG00000099246 E011 54.2202021 0.0023529478 0.319033005 0.55873908 10 27504328 27504369 42 + 1.639 1.695 0.188
ENSG00000099246 E012 58.3815514 0.0007362140 0.291701861 0.53235736 10 27504370 27504376 7 + 1.670 1.723 0.181
ENSG00000099246 E013 59.1146528 0.0007128726 0.183155899 0.40800931 10 27504377 27504382 6 + 1.671 1.739 0.230
ENSG00000099246 E014 73.4748369 0.0007439202 0.167470868 0.38721824 10 27504383 27504412 30 + 1.765 1.828 0.215
ENSG00000099246 E015 70.8516704 0.0005910773 0.219576475 0.45291203 10 27504413 27504437 25 + 1.750 1.807 0.191
ENSG00000099246 E016 0.3228314 0.3983643005 1.000000000   10 27504438 27504448 11 + 0.120 0.000 -9.964
ENSG00000099246 E017 0.0000000       10 27504619 27504724 106 +      
ENSG00000099246 E018 0.0000000       10 27504979 27505075 97 +      
ENSG00000099246 E019 0.0000000       10 27505076 27505190 115 +      
ENSG00000099246 E020 0.0000000       10 27508902 27509033 132 +      
ENSG00000099246 E021 60.5103429 0.0005937050 0.533564178 0.72460771 10 27509875 27509888 14 + 1.689 1.718 0.099
ENSG00000099246 E022 81.4839902 0.0006257312 0.432357124 0.65301235 10 27509889 27509930 42 + 1.817 1.849 0.108
ENSG00000099246 E023 0.7695163 0.0472414664 0.338053909   10 27509931 27510490 560 + 0.253 0.000 -11.938
ENSG00000099246 E024 0.1426347 0.0322745779 1.000000000   10 27512328 27512357 30 + 0.064 0.000 -9.748
ENSG00000099246 E025 0.3150090 0.0304195522 0.291448011   10 27513963 27513965 3 + 0.064 0.220 2.056
ENSG00000099246 E026 0.3150090 0.0304195522 0.291448011   10 27513966 27514054 89 + 0.064 0.220 2.056
ENSG00000099246 E027 0.8489605 0.2160655004 0.933692697   10 27514055 27514119 65 + 0.215 0.220 0.043
ENSG00000099246 E028 1.7471322 0.0148664058 0.929417205 0.96674395 10 27514120 27514420 301 + 0.385 0.364 -0.118
ENSG00000099246 E029 0.0000000       10 27526569 27526598 30 +      
ENSG00000099246 E030 101.4048187 0.0004579312 0.498877420 0.70001620 10 27526828 27526889 62 + 1.910 1.933 0.079
ENSG00000099246 E031 3.8628399 0.0063241585 0.846384622 0.92295738 10 27526890 27528515 1626 + 0.603 0.632 0.127
ENSG00000099246 E032 8.8277377 0.0161280504 0.001284556 0.01204634 10 27528516 27531528 3013 + 0.967 0.365 -2.649
ENSG00000099246 E033 1.9532470 0.0343991616 0.612195418 0.77831143 10 27531529 27531615 87 + 0.384 0.475 0.482
ENSG00000099246 E034 4.1266692 0.0084374032 0.688826278 0.82833286 10 27531616 27532382 767 + 0.636 0.560 -0.337
ENSG00000099246 E035 0.0000000       10 27532383 27532387 5 +      
ENSG00000099246 E036 0.4397201 0.0501460116 0.081356496   10 27532388 27532487 100 + 0.064 0.363 3.041
ENSG00000099246 E037 0.2617363 0.0582415611 0.020638408   10 27532488 27532506 19 + 0.000 0.362 12.609
ENSG00000099246 E038 89.9618093 0.0004526598 0.529271520 0.72154109 10 27532507 27532536 30 + 1.857 1.880 0.079
ENSG00000099246 E039 93.7184366 0.0004401091 0.518230168 0.71381275 10 27532537 27532579 43 + 1.887 1.853 -0.116
ENSG00000099246 E040 0.0000000       10 27532580 27533223 644 +      
ENSG00000099246 E041 0.3206185 0.0274424043 1.000000000   10 27533224 27533734 511 + 0.119 0.000 -10.744
ENSG00000099246 E042 141.4061700 0.0003449375 0.016879852 0.08501148 10 27533735 27533853 119 + 2.076 1.980 -0.320
ENSG00000099246 E043 13.2374631 0.1600794825 0.303594579 0.54415578 10 27533854 27533927 74 + 1.093 0.951 -0.523
ENSG00000099246 E044 73.1109398 0.0023314338 0.032189035 0.13378459 10 27533928 27533940 13 + 1.798 1.671 -0.430
ENSG00000099246 E045 98.3331270 0.0004584405 0.533215565 0.72434860 10 27533941 27533994 54 + 1.908 1.876 -0.108
ENSG00000099246 E046 0.0000000       10 27533995 27533998 4 +      
ENSG00000099246 E047 46.9169148 0.0007835659 0.860354854 0.93055536 10 27537876 27537877 2 + 1.586 1.592 0.022
ENSG00000099246 E048 126.7555920 0.0009829149 0.468292096 0.67890361 10 27537878 27538025 148 + 2.017 1.983 -0.116
ENSG00000099246 E049 52.4828574 0.0006984863 0.281882511 0.52220635 10 27538026 27538028 3 + 1.620 1.678 0.197
ENSG00000099246 E050 108.4522721 0.0005688363 0.274977037 0.51497508 10 27538029 27538222 194 + 1.932 1.972 0.132
ENSG00000099246 E051 394.7886499 0.0075349088 0.598694780 0.76936316 10 27538223 27542001 3779 + 2.506 2.471 -0.116
ENSG00000099246 E052 2.5258605 0.0137745148 0.030124300 0.12770661 10 27542002 27542205 204 + 0.384 0.748 1.691
ENSG00000099246 E053 1.3449587 0.2449636955 0.115453954   10 27542206 27542752 547 + 0.211 0.569 2.115
ENSG00000099246 E054 0.1779838 0.0354110249 1.000000000   10 27542753 27543207 455 + 0.064 0.000 -9.738