ENSG00000099246

1 Isoform Switch

Summary Plot
Results

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Rows: 1-7 / 7
Columns:
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isoform_id
gene_id
condition_1
condition_2
gene_name
gene_biotype
iso_biotype
gene_overall_mean
gene_value_1
gene_value_2
gene_stderr_1
gene_stderr_2
gene_log2_fold_change
iso_overall_mean
iso_value_1
iso_value_2
iso_stderr_1
iso_stderr_2
iso_log2_fold_change
IF_overall
IF1
IF2
dIF
isoform_switch_q_value
gene_switch_q_value
PTC
codingPotential
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isoform_id	gene_id	condition_1	condition_2	gene_name	gene_biotype	iso_biotype	gene_overall_mean	gene_value_1	gene_value_2	gene_stderr_1	gene_stderr_2	gene_log2_fold_change	iso_overall_mean	iso_value_1	iso_value_2	iso_stderr_1	iso_stderr_2	iso_log2_fold_change	IF_overall	IF1	IF2	dIF	isoform_switch_q_value	gene_switch_q_value	PTC

ENST00000375802	ENSG00000099246	HEK293_OSMI2_6hA	HEK293_TMG_6hB	RAB18	protein_coding	protein_coding	22.23115	6.840685	39.92228	0.9656762	2.512699	2.543235	1.5730006	0.5192334	3.029181	0.5192334	0.8410543	2.521706	0.07069583	0.07523333	0.07810000	0.002866667	0.565419709	0.007695632	FALSE
ENST00000682963	ENSG00000099246	HEK293_OSMI2_6hA	HEK293_TMG_6hB	RAB18	protein_coding	protein_coding	22.23115	6.840685	39.92228	0.9656762	2.512699	2.543235	0.7608535	0.0000000	2.651910	0.0000000	1.2453488	8.056318	0.02373750	0.00000000	0.06300000	0.063000000	0.007695632	0.007695632
ENST00000683042	ENSG00000099246	HEK293_OSMI2_6hA	HEK293_TMG_6hB	RAB18	protein_coding	retained_intron	22.23115	6.840685	39.92228	0.9656762	2.512699	2.543235	4.8748674	1.1885969	9.818121	0.9096412	0.8543143	3.035569	0.23158333	0.15520000	0.25073333	0.095533333	0.770769128	0.007695632	TRUE
ENST00000683446	ENSG00000099246	HEK293_OSMI2_6hA	HEK293_TMG_6hB	RAB18	protein_coding	retained_intron	22.23115	6.840685	39.92228	0.9656762	2.512699	2.543235	1.0022047	0.4006959	0.000000	0.4006959	0.0000000	-5.359999	0.07341667	0.04723333	0.00000000	-0.047233333	0.643450446	0.007695632
ENST00000683755	ENSG00000099246	HEK293_OSMI2_6hA	HEK293_TMG_6hB	RAB18	protein_coding	protein_coding	22.23115	6.840685	39.92228	0.9656762	2.512699	2.543235	2.6001865	1.0112235	3.114757	0.1716753	1.8934184	1.613445	0.12877500	0.14646667	0.08483333	-0.061633333	0.793942762	0.007695632	FALSE
ENST00000683797	ENSG00000099246	HEK293_OSMI2_6hA	HEK293_TMG_6hB	RAB18	protein_coding	protein_coding	22.23115	6.840685	39.92228	0.9656762	2.512699	2.543235	6.8414121	2.0928041	14.065726	0.3003670	1.1974506	2.742823	0.28125417	0.30616667	0.35180000	0.045633333	0.715999067	0.007695632	FALSE
ENST00000684501	ENSG00000099246	HEK293_OSMI2_6hA	HEK293_TMG_6hB	RAB18	protein_coding	protein_coding	22.23115	6.840685	39.92228	0.9656762	2.512699	2.543235	3.2321601	1.2009533	5.406322	0.6021155	3.0099143	2.161170	0.11966250	0.20513333	0.12676667	-0.078366667	0.972233705	0.007695632	FALSE

Note:
- The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

All exons whithin this gene region are shown and numbering below.

All isoforms whithin this gene region are shown below.

Rows: 1-10 / 54
Columns:
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groupID
featureID
exonBaseMean
dispersion
pvalue
padj
seqnames
start
end
width
strand
HEK293_TMG_6hB
HEK293_OSMI2_6hA
log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
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groupID	featureID	exonBaseMean	dispersion	pvalue	padj	seqnames	start	end	width	strand	HEK293_TMG_6hB	HEK293_OSMI2_6hA	log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB

ENSG00000099246	E001	0.6129023	0.0190306359	0.774771311		10	27504174	27504233	60	+	0.169	0.219	0.466
ENSG00000099246	E002	1.0595873	0.0148250654	0.748351752		10	27504234	27504279	46	+	0.290	0.219	-0.532
ENSG00000099246	E003	1.0595873	0.0148250654	0.748351752		10	27504280	27504285	6	+	0.290	0.219	-0.532
ENSG00000099246	E004	1.0595873	0.0148250654	0.748351752		10	27504286	27504293	8	+	0.290	0.219	-0.532
ENSG00000099246	E005	1.2022220	0.0153787590	0.625054160		10	27504294	27504298	5	+	0.324	0.219	-0.754
ENSG00000099246	E006	1.3282884	0.1219300346	0.582804342		10	27504299	27504303	5	+	0.352	0.218	-0.938
ENSG00000099246	E007	3.3157871	0.0514546176	0.918311567	0.96136019	10	27504304	27504311	8	+	0.582	0.557	-0.116
ENSG00000099246	E008	3.4584217	0.0719073926	0.864898167	0.93308358	10	27504312	27504313	2	+	0.598	0.556	-0.192
ENSG00000099246	E009	10.3049241	0.0359750881	0.558876763	0.74244944	10	27504314	27504317	4	+	0.991	0.909	-0.308
ENSG00000099246	E010	22.5535004	0.0367321453	0.748399369	0.86573138	10	27504318	27504327	10	+	1.272	1.332	0.207
ENSG00000099246	E011	54.2202021	0.0023529478	0.319033005	0.55873908	10	27504328	27504369	42	+	1.639	1.695	0.188
ENSG00000099246	E012	58.3815514	0.0007362140	0.291701861	0.53235736	10	27504370	27504376	7	+	1.670	1.723	0.181
ENSG00000099246	E013	59.1146528	0.0007128726	0.183155899	0.40800931	10	27504377	27504382	6	+	1.671	1.739	0.230
ENSG00000099246	E014	73.4748369	0.0007439202	0.167470868	0.38721824	10	27504383	27504412	30	+	1.765	1.828	0.215
ENSG00000099246	E015	70.8516704	0.0005910773	0.219576475	0.45291203	10	27504413	27504437	25	+	1.750	1.807	0.191
ENSG00000099246	E016	0.3228314	0.3983643005	1.000000000		10	27504438	27504448	11	+	0.120	0.000	-9.964
ENSG00000099246	E017	0.0000000				10	27504619	27504724	106	+
ENSG00000099246	E018	0.0000000				10	27504979	27505075	97	+
ENSG00000099246	E019	0.0000000				10	27505076	27505190	115	+
ENSG00000099246	E020	0.0000000				10	27508902	27509033	132	+
ENSG00000099246	E021	60.5103429	0.0005937050	0.533564178	0.72460771	10	27509875	27509888	14	+	1.689	1.718	0.099
ENSG00000099246	E022	81.4839902	0.0006257312	0.432357124	0.65301235	10	27509889	27509930	42	+	1.817	1.849	0.108
ENSG00000099246	E023	0.7695163	0.0472414664	0.338053909		10	27509931	27510490	560	+	0.253	0.000	-11.938
ENSG00000099246	E024	0.1426347	0.0322745779	1.000000000		10	27512328	27512357	30	+	0.064	0.000	-9.748
ENSG00000099246	E025	0.3150090	0.0304195522	0.291448011		10	27513963	27513965	3	+	0.064	0.220	2.056
ENSG00000099246	E026	0.3150090	0.0304195522	0.291448011		10	27513966	27514054	89	+	0.064	0.220	2.056
ENSG00000099246	E027	0.8489605	0.2160655004	0.933692697		10	27514055	27514119	65	+	0.215	0.220	0.043
ENSG00000099246	E028	1.7471322	0.0148664058	0.929417205	0.96674395	10	27514120	27514420	301	+	0.385	0.364	-0.118
ENSG00000099246	E029	0.0000000				10	27526569	27526598	30	+
ENSG00000099246	E030	101.4048187	0.0004579312	0.498877420	0.70001620	10	27526828	27526889	62	+	1.910	1.933	0.079
ENSG00000099246	E031	3.8628399	0.0063241585	0.846384622	0.92295738	10	27526890	27528515	1626	+	0.603	0.632	0.127
ENSG00000099246	E032	8.8277377	0.0161280504	0.001284556	0.01204634	10	27528516	27531528	3013	+	0.967	0.365	-2.649
ENSG00000099246	E033	1.9532470	0.0343991616	0.612195418	0.77831143	10	27531529	27531615	87	+	0.384	0.475	0.482
ENSG00000099246	E034	4.1266692	0.0084374032	0.688826278	0.82833286	10	27531616	27532382	767	+	0.636	0.560	-0.337
ENSG00000099246	E035	0.0000000				10	27532383	27532387	5	+
ENSG00000099246	E036	0.4397201	0.0501460116	0.081356496		10	27532388	27532487	100	+	0.064	0.363	3.041
ENSG00000099246	E037	0.2617363	0.0582415611	0.020638408		10	27532488	27532506	19	+	0.000	0.362	12.609
ENSG00000099246	E038	89.9618093	0.0004526598	0.529271520	0.72154109	10	27532507	27532536	30	+	1.857	1.880	0.079
ENSG00000099246	E039	93.7184366	0.0004401091	0.518230168	0.71381275	10	27532537	27532579	43	+	1.887	1.853	-0.116
ENSG00000099246	E040	0.0000000				10	27532580	27533223	644	+
ENSG00000099246	E041	0.3206185	0.0274424043	1.000000000		10	27533224	27533734	511	+	0.119	0.000	-10.744
ENSG00000099246	E042	141.4061700	0.0003449375	0.016879852	0.08501148	10	27533735	27533853	119	+	2.076	1.980	-0.320
ENSG00000099246	E043	13.2374631	0.1600794825	0.303594579	0.54415578	10	27533854	27533927	74	+	1.093	0.951	-0.523
ENSG00000099246	E044	73.1109398	0.0023314338	0.032189035	0.13378459	10	27533928	27533940	13	+	1.798	1.671	-0.430
ENSG00000099246	E045	98.3331270	0.0004584405	0.533215565	0.72434860	10	27533941	27533994	54	+	1.908	1.876	-0.108
ENSG00000099246	E046	0.0000000				10	27533995	27533998	4	+
ENSG00000099246	E047	46.9169148	0.0007835659	0.860354854	0.93055536	10	27537876	27537877	2	+	1.586	1.592	0.022
ENSG00000099246	E048	126.7555920	0.0009829149	0.468292096	0.67890361	10	27537878	27538025	148	+	2.017	1.983	-0.116
ENSG00000099246	E049	52.4828574	0.0006984863	0.281882511	0.52220635	10	27538026	27538028	3	+	1.620	1.678	0.197
ENSG00000099246	E050	108.4522721	0.0005688363	0.274977037	0.51497508	10	27538029	27538222	194	+	1.932	1.972	0.132
ENSG00000099246	E051	394.7886499	0.0075349088	0.598694780	0.76936316	10	27538223	27542001	3779	+	2.506	2.471	-0.116
ENSG00000099246	E052	2.5258605	0.0137745148	0.030124300	0.12770661	10	27542002	27542205	204	+	0.384	0.748	1.691
ENSG00000099246	E053	1.3449587	0.2449636955	0.115453954		10	27542206	27542752	547	+	0.211	0.569	2.115
ENSG00000099246	E054	0.1779838	0.0354110249	1.000000000		10	27542753	27543207	455	+	0.064	0.000	-9.738

Isoforom Switch Analysis

WANG Ziyi

Date: 19 5月 2022

ENSG00000099246

1 Isoform Switch

TableFilter v0.7.3

2 Differential Exon Usage

TableFilter v0.7.3