ENSG00000096060

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357266 ENSG00000096060 HEK293_OSMI2_6hA HEK293_TMG_6hB FKBP5 protein_coding protein_coding 21.27233 14.51625 23.89633 3.76963 1.312279 0.7187302 19.32851 14.08789 21.05808 3.64065 1.311518 0.5795788 0.919075 0.9709 0.8809 -0.09 0.006374315 0.0005224263 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000096060 E001 3.0553000 0.0091501306 8.439288e-01 0.9215543419 6 35573585 35573589 5 - 0.570 0.610 0.181
ENSG00000096060 E002 706.0959353 0.0020275647 6.381439e-06 0.0001423831 6 35573590 35575183 1594 - 2.794 2.903 0.362
ENSG00000096060 E003 186.6874717 0.0002682460 2.299112e-01 0.4650832820 6 35575184 35575394 211 - 2.248 2.291 0.144
ENSG00000096060 E004 106.8836493 0.0004568768 7.386154e-02 0.2324880499 6 35575395 35575507 113 - 1.992 2.066 0.250
ENSG00000096060 E005 295.1445045 0.0002488460 8.528082e-01 0.9265696099 6 35575508 35575938 431 - 2.463 2.471 0.028
ENSG00000096060 E006 93.1700482 0.0005488639 5.640143e-01 0.7461272792 6 35575939 35575942 4 - 1.972 1.962 -0.036
ENSG00000096060 E007 247.5847743 0.0002422996 4.690285e-01 0.6794144690 6 35576994 35577233 240 - 2.393 2.389 -0.013
ENSG00000096060 E008 207.7837174 0.0010135181 7.005233e-01 0.8359649366 6 35580036 35580221 186 - 2.315 2.318 0.008
ENSG00000096060 E009 19.7233225 0.3520203860 2.532216e-01 0.4914443910 6 35580557 35587033 6477 - 1.396 1.151 -0.860
ENSG00000096060 E010 146.7467123 0.0016005972 3.932685e-01 0.6229749534 6 35587034 35587117 84 - 2.174 2.157 -0.056
ENSG00000096060 E011 133.3740999 0.0009305318 1.162208e-02 0.0649004450 6 35591130 35591220 91 - 2.155 2.084 -0.241
ENSG00000096060 E012 177.5369240 0.0002546346 6.643943e-03 0.0429156139 6 35597248 35597404 157 - 2.271 2.210 -0.204
ENSG00000096060 E013 143.8067359 0.0004584528 3.696775e-01 0.6037559281 6 35619096 35619210 115 - 2.159 2.144 -0.052
ENSG00000096060 E014 130.1998558 0.0003765890 2.408227e-01 0.4775216707 6 35620132 35620274 143 - 2.121 2.095 -0.084
ENSG00000096060 E015 132.5981587 0.0003889874 9.660392e-03 0.0566616428 6 35637014 35637158 145 - 2.151 2.081 -0.233
ENSG00000096060 E016 116.1586780 0.0007631153 1.623904e-02 0.0826716836 6 35642720 35642843 124 - 2.095 2.023 -0.240
ENSG00000096060 E017 1.2600385 0.4888835998 6.554957e-01   6 35643277 35643348 72 - 0.380 0.258 -0.785
ENSG00000096060 E018 4.7355938 0.0066791427 2.011284e-06 0.0000524915 6 35646163 35646366 204 - 0.935 0.141 -4.308
ENSG00000096060 E019 2.0119912 0.0108647759 9.702294e-01 0.9869790690 6 35646730 35646850 121 - 0.462 0.465 0.015
ENSG00000096060 E020 0.1723744 0.0872915486 3.548280e-01   6 35688732 35688803 72 - 0.000 0.141 10.568
ENSG00000096060 E021 65.5961436 0.0006459739 1.708210e-01 0.3915998840 6 35688804 35688966 163 - 1.841 1.792 -0.165
ENSG00000096060 E022 0.4231520 0.0600624444 4.179688e-01   6 35720328 35720548 221 - 0.104 0.246 1.487
ENSG00000096060 E023 0.1614157 0.0343015382 6.737127e-01   6 35728508 35728583 76 - 0.104 0.000 -9.601