ENSG00000095787

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000354911 ENSG00000095787 HEK293_OSMI2_6hA HEK293_TMG_6hB WAC protein_coding protein_coding 35.49216 18.40269 61.15084 3.75506 1.462874 1.731908 6.6987071 5.079610 8.5493340 1.06945412 0.5862068 0.7499435 0.21674583 0.27520000 0.139900000 -0.13530000 5.618037e-05 2.341431e-09 FALSE TRUE
ENST00000424454 ENSG00000095787 HEK293_OSMI2_6hA HEK293_TMG_6hB WAC protein_coding nonsense_mediated_decay 35.49216 18.40269 61.15084 3.75506 1.462874 1.731908 6.6093866 1.861689 11.9535445 0.08550868 1.5960917 2.6762319 0.13893750 0.11063333 0.195633333 0.08500000 3.423161e-01 2.341431e-09 FALSE TRUE
ENST00000651598 ENSG00000095787 HEK293_OSMI2_6hA HEK293_TMG_6hB WAC protein_coding protein_coding 35.49216 18.40269 61.15084 3.75506 1.462874 1.731908 7.0072183 3.212321 13.3188773 0.92562370 0.7060695 2.0483829 0.14808333 0.17003333 0.218500000 0.04846667 6.924568e-01 2.341431e-09 FALSE TRUE
ENST00000651885 ENSG00000095787 HEK293_OSMI2_6hA HEK293_TMG_6hB WAC protein_coding protein_coding 35.49216 18.40269 61.15084 3.75506 1.462874 1.731908 2.9076022 0.000000 7.1692440 0.00000000 1.9420753 9.4876881 0.05332500 0.00000000 0.115966667 0.11596667 2.341431e-09 2.341431e-09 FALSE FALSE
MSTRG.3722.24 ENSG00000095787 HEK293_OSMI2_6hA HEK293_TMG_6hB WAC protein_coding   35.49216 18.40269 61.15084 3.75506 1.462874 1.731908 1.3739882 0.000000 4.0298557 0.00000000 2.0631280 8.6581600 0.02663333 0.00000000 0.066866667 0.06686667 4.283053e-01 2.341431e-09 FALSE TRUE
MSTRG.3722.33 ENSG00000095787 HEK293_OSMI2_6hA HEK293_TMG_6hB WAC protein_coding   35.49216 18.40269 61.15084 3.75506 1.462874 1.731908 0.8607973 1.668711 0.4330133 0.09984956 0.4330133 -1.9219318 0.05829583 0.09816667 0.007433333 -0.09073333 8.150138e-02 2.341431e-09 FALSE TRUE
MSTRG.3722.6 ENSG00000095787 HEK293_OSMI2_6hA HEK293_TMG_6hB WAC protein_coding   35.49216 18.40269 61.15084 3.75506 1.462874 1.731908 2.1782910 3.070045 0.8920078 0.93568136 0.8920078 -1.7717397 0.11100000 0.15773333 0.014133333 -0.14360000 9.355076e-02 2.341431e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000095787 E001 0.3040503 0.0274424043 4.853737e-01   10 28532493 28532748 256 + 0.160 0.000 -9.516
ENSG00000095787 E002 0.6081007 0.0220691185 1.565750e-01   10 28532749 28532754 6 + 0.276 0.000 -12.733
ENSG00000095787 E003 1.2647220 0.3008069631 3.790481e-01   10 28532755 28532767 13 + 0.406 0.168 -1.715
ENSG00000095787 E004 1.5687724 0.3243937885 2.789536e-01 0.5190224419 10 28532768 28532770 3 + 0.474 0.168 -2.070
ENSG00000095787 E005 2.4128138 0.2645322905 2.610600e-01 0.5001013809 10 28532771 28532772 2 + 0.605 0.285 -1.708
ENSG00000095787 E006 2.7466038 0.4140419959 5.085435e-01 0.7068514817 10 28532773 28532775 3 + 0.626 0.379 -1.211
ENSG00000095787 E007 2.7466038 0.4140419959 5.085435e-01 0.7068514817 10 28532776 28532778 3 + 0.626 0.379 -1.211
ENSG00000095787 E008 3.8523815 0.4669882367 7.719527e-01 0.8797750573 10 28532779 28532783 5 + 0.719 0.563 -0.675
ENSG00000095787 E009 35.9414942 0.7894773863 4.522157e-01 0.6673269730 10 28532784 28532886 103 + 1.484 1.640 0.533
ENSG00000095787 E010 22.9443273 0.6607236536 5.011724e-01 0.7016248130 10 28532887 28532888 2 + 1.308 1.435 0.442
ENSG00000095787 E011 46.0346400 0.8569391239 4.311636e-01 0.6520401172 10 28532889 28533007 119 + 1.579 1.758 0.608
ENSG00000095787 E012 43.0988479 0.0013905420 6.394584e-05 0.0010280672 10 28533118 28533312 195 + 1.525 1.767 0.821
ENSG00000095787 E013 41.9074919 0.0011498202 9.301974e-05 0.0014081736 10 28533313 28533370 58 + 1.519 1.756 0.806
ENSG00000095787 E014 47.6031512 0.0009405594 1.479169e-04 0.0020734376 10 28533371 28533499 129 + 1.579 1.797 0.739
ENSG00000095787 E015 6.1032205 0.0175889257 1.040337e-01 0.2888735205 10 28533500 28533500 1 + 0.737 0.973 0.911
ENSG00000095787 E016 7.6687846 0.0060211241 8.562155e-02 0.2557135093 10 28533501 28533505 5 + 0.832 1.052 0.827
ENSG00000095787 E017 18.4879467 0.0087094051 8.444392e-01 0.9218346132 10 28533506 28533539 34 + 1.249 1.284 0.125
ENSG00000095787 E018 40.5582060 0.0011162328 2.775733e-01 0.5176339213 10 28533540 28533582 43 + 1.602 1.557 -0.152
ENSG00000095787 E019 40.6481539 0.0010656925 3.930458e-02 0.1529938110 10 28533583 28533596 14 + 1.621 1.516 -0.358
ENSG00000095787 E020 55.5279686 0.0007871613 1.542382e-02 0.0796896682 10 28533597 28533620 24 + 1.755 1.648 -0.362
ENSG00000095787 E021 0.0000000       10 28533749 28533762 14 +      
ENSG00000095787 E022 3.0524351 0.0779291162 8.606485e-01 0.9306812539 10 28533763 28533893 131 + 0.611 0.578 -0.149
ENSG00000095787 E023 1.9405004 0.0137744915 5.457191e-01 0.7332376819 10 28533894 28533997 104 + 0.478 0.381 -0.516
ENSG00000095787 E024 105.6058762 0.0040283906 3.072886e-01 0.5479002546 10 28533998 28534034 37 + 2.013 1.984 -0.095
ENSG00000095787 E025 1.9624904 0.0217554865 5.358955e-01 0.7262610702 10 28534035 28534122 88 + 0.478 0.380 -0.520
ENSG00000095787 E026 1.4391377 0.0613869132 4.738560e-01 0.6827036317 10 28534123 28534182 60 + 0.410 0.285 -0.759
ENSG00000095787 E027 1.6240864 0.0117607003 9.324228e-03 0.0551981170 10 28534234 28534346 113 + 0.509 0.000 -14.086
ENSG00000095787 E028 1.8578479 0.0106951067 5.555616e-01 0.7401578830 10 28535266 28535543 278 + 0.408 0.523 0.584
ENSG00000095787 E029 27.3311459 0.0095618598 7.760822e-02 0.2400377296 10 28535544 28535561 18 + 1.469 1.333 -0.469
ENSG00000095787 E030 216.6865461 0.0003117094 4.410618e-05 0.0007480270 10 28535562 28535685 124 + 2.340 2.252 -0.296
ENSG00000095787 E031 196.9177746 0.0002805524 4.552835e-05 0.0007681829 10 28535686 28535757 72 + 2.299 2.205 -0.312
ENSG00000095787 E032 0.8018448 0.0213546333 7.568071e-01   10 28535758 28535909 152 + 0.222 0.286 0.483
ENSG00000095787 E033 0.4514866 0.0217681645 1.000000e+00   10 28535910 28535918 9 + 0.160 0.166 0.068
ENSG00000095787 E034 1.1904555 0.0136968632 6.110842e-01   10 28535919 28536059 141 + 0.368 0.286 -0.516
ENSG00000095787 E035 0.9866059 0.0442691722 3.869693e-01   10 28537584 28537815 232 + 0.325 0.167 -1.245
ENSG00000095787 E036 0.3337900 0.0420502073 6.037865e-01   10 28537950 28538066 117 + 0.087 0.167 1.072
ENSG00000095787 E037 123.2434780 0.0015949513 6.007288e-03 0.0397558788 10 28583399 28583405 7 + 2.097 2.010 -0.293
ENSG00000095787 E038 263.8491504 0.0002293310 8.273913e-04 0.0085028788 10 28583406 28583505 100 + 2.414 2.355 -0.197
ENSG00000095787 E039 1.9161099 0.0506421341 9.600539e-01 0.9818683018 10 28588737 28589735 999 + 0.444 0.458 0.072
ENSG00000095787 E040 305.9633386 0.0024935567 2.325201e-02 0.1067569373 10 28589736 28589851 116 + 2.476 2.422 -0.181
ENSG00000095787 E041 162.0960285 0.0062387795 1.412919e-01 0.3494387021 10 28590720 28590721 2 + 2.202 2.144 -0.194
ENSG00000095787 E042 290.9483912 0.0037896427 9.907006e-02 0.2801319598 10 28590722 28590832 111 + 2.452 2.408 -0.147
ENSG00000095787 E043 1.5629913 0.0232023911 3.584901e-01 0.5945705364 10 28590833 28591833 1001 + 0.444 0.286 -0.936
ENSG00000095787 E044 1.0241679 0.0153787590 3.697951e-01   10 28595695 28595732 38 + 0.325 0.167 -1.251
ENSG00000095787 E045 328.9054656 0.0023626947 4.692071e-01 0.6795340321 10 28595733 28596041 309 + 2.491 2.489 -0.008
ENSG00000095787 E046 280.8416734 0.0027453743 5.086371e-01 0.7069023660 10 28608186 28608345 160 + 2.424 2.420 -0.014
ENSG00000095787 E047 191.1898341 0.0061124918 9.182612e-01 0.9613593774 10 28608346 28608431 86 + 2.254 2.267 0.045
ENSG00000095787 E048 1.5938987 0.0121989077 8.309888e-01 0.9143482136 10 28608432 28608593 162 + 0.408 0.381 -0.150
ENSG00000095787 E049 94.7277775 0.0009265366 6.667479e-01 0.8141644960 10 28610699 28610707 9 + 1.956 1.960 0.012
ENSG00000095787 E050 97.2719368 0.0011797907 6.129215e-01 0.7788990454 10 28610708 28610710 3 + 1.969 1.968 -0.001
ENSG00000095787 E051 251.0484917 0.0005563759 2.073021e-01 0.4385769203 10 28610711 28610821 111 + 2.381 2.370 -0.037
ENSG00000095787 E052 10.6269900 0.2942578147 1.292785e-01 0.3306146962 10 28610822 28611254 433 + 1.129 0.765 -1.371
ENSG00000095787 E053 14.9203227 0.1462790925 9.982535e-02 0.2814449959 10 28611255 28611481 227 + 1.259 0.932 -1.181
ENSG00000095787 E054 10.0224513 0.1996980745 5.069054e-01 0.7056081134 10 28611482 28611773 292 + 1.055 0.927 -0.473
ENSG00000095787 E055 348.5131470 0.0002355901 3.800143e-01 0.6121836495 10 28611774 28611922 149 + 2.517 2.519 0.009
ENSG00000095787 E056 309.0899374 0.0002147228 5.854166e-01 0.7605646182 10 28614567 28614685 119 + 2.453 2.485 0.108
ENSG00000095787 E057 4.8143003 0.0677327830 4.725843e-02 0.1731663683 10 28614686 28614998 313 + 0.834 0.456 -1.645
ENSG00000095787 E058 5.6907717 0.1618078586 3.122202e-01 0.5525329648 10 28614999 28615327 329 + 0.861 0.636 -0.912
ENSG00000095787 E059 7.2980997 0.3592479629 3.568994e-01 0.5932126243 10 28615328 28615573 246 + 0.951 0.757 -0.749
ENSG00000095787 E060 11.3310098 0.3931190264 3.431310e-01 0.5807870674 10 28615574 28616172 599 + 1.115 0.939 -0.643
ENSG00000095787 E061 99.5210481 0.0003956284 6.695187e-01 0.8159788666 10 28616173 28616175 3 + 1.973 1.978 0.014
ENSG00000095787 E062 377.0661974 0.0001766757 4.640417e-02 0.1710333735 10 28616176 28616362 187 + 2.531 2.590 0.196
ENSG00000095787 E063 337.8107229 0.0029889548 2.329589e-02 0.1068804160 10 28617657 28617784 128 + 2.469 2.565 0.320
ENSG00000095787 E064 3.5386036 0.0074594438 3.891969e-02 0.1519590357 10 28617785 28618041 257 + 0.718 0.381 -1.592
ENSG00000095787 E065 1252.0519243 0.0045138561 2.374154e-03 0.0195317989 10 28619537 28623112 3576 + 3.030 3.143 0.377