ENSG00000095777

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000376301 ENSG00000095777 HEK293_OSMI2_6hA HEK293_TMG_6hB MYO3A protein_coding retained_intron 0.9803939 0.4955435 1.195426 0.07647084 0.1224333 1.253636 0.24821370 0.00000000 0.63200638 0.00000000 0.08883593 6.0045157 0.18337917 0.00000000 0.52396667 0.52396667 6.670221e-07 6.670221e-07 FALSE TRUE
ENST00000376302 ENSG00000095777 HEK293_OSMI2_6hA HEK293_TMG_6hB MYO3A protein_coding protein_coding 0.9803939 0.4955435 1.195426 0.07647084 0.1224333 1.253636 0.06191320 0.04190372 0.04819218 0.01533830 0.01540285 0.1649874 0.07927083 0.09700000 0.04126667 -0.05573333 8.087380e-01 6.670221e-07 FALSE TRUE
ENST00000478093 ENSG00000095777 HEK293_OSMI2_6hA HEK293_TMG_6hB MYO3A protein_coding protein_coding 0.9803939 0.4955435 1.195426 0.07647084 0.1224333 1.253636 0.04788617 0.03110281 0.00000000 0.03110281 0.00000000 -2.0392370 0.06170000 0.08856667 0.00000000 -0.08856667 7.553949e-01 6.670221e-07   FALSE
ENST00000642920 ENSG00000095777 HEK293_OSMI2_6hA HEK293_TMG_6hB MYO3A protein_coding protein_coding 0.9803939 0.4955435 1.195426 0.07647084 0.1224333 1.253636 0.49597270 0.38181571 0.41163748 0.09590608 0.01650175 0.1058279 0.54060000 0.74613333 0.34936667 -0.39676667 8.821531e-02 6.670221e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000095777 E001 1.3378216 0.225276597 0.637953931   10 25934229 25934273 45 + 0.415 0.299 -0.695
ENSG00000095777 E002 2.1251235 0.142269960 0.841263385 0.92016676 10 25934274 25934328 55 + 0.508 0.473 -0.173
ENSG00000095777 E003 2.8372150 0.012064969 0.404699171 0.63208732 10 25935744 25935787 44 + 0.503 0.638 0.612
ENSG00000095777 E004 3.0080121 0.009766448 0.202508966 0.43275058 10 25935788 25935830 43 + 0.677 0.478 -0.904
ENSG00000095777 E005 1.5227703 0.014349694 0.017886575 0.08865917 10 25952094 25952099 6 + 0.544 0.125 -2.904
ENSG00000095777 E006 5.6356667 0.016546116 0.850038461 0.92499187 10 25952100 25952278 179 + 0.821 0.803 -0.073
ENSG00000095777 E007 6.9154268 0.004601205 0.243746306 0.48077739 10 25954874 25955008 135 + 0.960 0.824 -0.518
ENSG00000095777 E008 5.7728630 0.006611534 0.003131077 0.02419479 10 25996490 25996594 105 + 0.988 0.602 -1.543
ENSG00000095777 E009 4.7493153 0.011091874 0.004124036 0.02986084 10 25997159 25997258 100 + 0.928 0.522 -1.684
ENSG00000095777 E010 4.1775439 0.010496208 0.052890378 0.18646853 10 26016820 26016896 77 + 0.840 0.564 -1.152
ENSG00000095777 E011 0.1614157 0.033153193 0.526620719   10 26016897 26016915 19 + 0.118 0.000 -10.978
ENSG00000095777 E012 5.1539759 0.006112139 0.083555404 0.25188669 10 26021503 26021648 146 + 0.895 0.669 -0.904
ENSG00000095777 E013 2.0363091 0.021209541 0.899652779 0.95170951 10 26021649 26023481 1833 + 0.459 0.478 0.100
ENSG00000095777 E014 2.0366395 0.010097920 0.062460859 0.20827987 10 26024022 26024087 66 + 0.615 0.301 -1.641
ENSG00000095777 E015 2.8523782 0.009852230 0.902746393 0.95321860 10 26026377 26026532 156 + 0.581 0.565 -0.072
ENSG00000095777 E016 2.4755340 0.123662663 0.952850974 0.97842603 10 26066975 26067074 100 + 0.505 0.533 0.132
ENSG00000095777 E017 1.9628503 0.011081623 0.641154531 0.79762504 10 26068768 26068884 117 + 0.503 0.426 -0.389
ENSG00000095777 E018 1.9380999 0.012170185 0.296078751 0.53661049 10 26070111 26070215 105 + 0.544 0.368 -0.905
ENSG00000095777 E019 1.5938987 0.012518589 0.244053986 0.48110206 10 26070318 26070401 84 + 0.503 0.301 -1.124
ENSG00000095777 E020 3.2610685 0.008289330 0.462222629 0.67467174 10 26088203 26088405 203 + 0.676 0.565 -0.486
ENSG00000095777 E021 2.5971064 0.009073089 0.898861887 0.95129951 10 26096381 26096479 99 + 0.543 0.565 0.098
ENSG00000095777 E022 2.9722150 0.009045670 0.545970533 0.73340363 10 26096568 26096682 115 + 0.543 0.638 0.421
ENSG00000095777 E023 2.1767308 0.024580863 0.893719184 0.94853460 10 26120676 26120802 127 + 0.503 0.478 -0.121
ENSG00000095777 E024 2.3381465 0.011255687 0.689671746 0.82881092 10 26125398 26125608 211 + 0.544 0.478 -0.316
ENSG00000095777 E025 1.4461025 0.012164487 0.001160225 0.01112798 10 26128391 26128538 148 + 0.581 0.000 -14.148
ENSG00000095777 E026 2.6624556 0.030448976 0.396197107 0.62533348 10 26143448 26143601 154 + 0.616 0.477 -0.646
ENSG00000095777 E027 3.0244628 0.008067947 0.310592139 0.55108176 10 26145446 26145534 89 + 0.676 0.523 -0.681
ENSG00000095777 E028 4.2506273 0.007243982 0.425114150 0.64734958 10 26147430 26147559 130 + 0.777 0.669 -0.444
ENSG00000095777 E029 3.2945690 0.009660558 0.612780497 0.77877809 10 26153850 26153929 80 + 0.676 0.602 -0.319
ENSG00000095777 E030 3.2819947 0.008636235 0.437454578 0.65683358 10 26154746 26154823 78 + 0.581 0.699 0.509
ENSG00000095777 E031 4.3840477 0.012900710 0.151729264 0.36484416 10 26157310 26157515 206 + 0.615 0.824 0.858
ENSG00000095777 E032 0.0000000       10 26165842 26166066 225 +      
ENSG00000095777 E033 4.0301891 0.060905630 0.681533447 0.82360849 10 26166067 26166178 112 + 0.650 0.728 0.326
ENSG00000095777 E034 0.0000000       10 26166179 26166239 61 +      
ENSG00000095777 E035 5.8243353 0.049256536 0.517501187 0.71330041 10 26168712 26168839 128 + 0.757 0.872 0.455
ENSG00000095777 E036 3.8868692 0.017156836 0.124808358 0.32343974 10 26168840 26168874 35 + 0.543 0.780 1.011
ENSG00000095777 E037 5.2620627 0.005380276 0.052301634 0.18504978 10 26170416 26170539 124 + 0.647 0.904 1.031
ENSG00000095777 E038 15.0102836 0.027912450 0.155662618 0.37041578 10 26173663 26174557 895 + 1.127 1.288 0.569
ENSG00000095777 E039 1.1625981 0.227881425 0.595581250   10 26176701 26176845 145 + 0.288 0.371 0.521
ENSG00000095777 E040 1.9994871 0.010864776 0.355906352 0.59242606 10 26193205 26193311 107 + 0.408 0.564 0.773
ENSG00000095777 E041 0.3503582 0.037166954 0.964068437   10 26200848 26201058 211 + 0.118 0.125 0.096
ENSG00000095777 E042 2.3033946 0.058900190 0.105492936 0.29148772 10 26201265 26201305 41 + 0.352 0.638 1.423
ENSG00000095777 E043 0.0000000       10 26202721 26202766 46 +      
ENSG00000095777 E044 2.6152672 0.096216317 0.533417438 0.72452527 10 26202964 26203107 144 + 0.504 0.604 0.460
ENSG00000095777 E045 0.1723744 0.055413024 0.451891663   10 26204085 26204502 418 + 0.000 0.125 11.137
ENSG00000095777 E046 6.3069820 0.083416223 0.164914431 0.38389458 10 26211843 26212209 367 + 0.753 0.966 0.824
ENSG00000095777 E047 4.1716382 0.006490336 0.011804499 0.06566248 10 26212210 26212333 124 + 0.503 0.865 1.537
ENSG00000095777 E048 3.1905219 0.007960657 0.027168957 0.11879895 10 26212334 26212393 60 + 0.408 0.754 1.584
ENSG00000095777 E049 2.6837373 0.009074180 0.007437852 0.04674062 10 26212394 26212532 139 + 0.287 0.728 2.213