ENSG00000095564

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265990 ENSG00000095564 HEK293_OSMI2_6hA HEK293_TMG_6hB BTAF1 protein_coding protein_coding 10.0304 3.766125 17.8833 0.2893856 0.552944 2.244441 5.2364087 1.7133456 9.993997 0.1991138 0.1578884 2.537293 0.5351292 0.4695333 0.5604667 0.09093333 8.030883e-01 3.565577e-17 FALSE TRUE
MSTRG.4377.1 ENSG00000095564 HEK293_OSMI2_6hA HEK293_TMG_6hB BTAF1 protein_coding   10.0304 3.766125 17.8833 0.2893856 0.552944 2.244441 1.6550720 0.0000000 2.592217 0.0000000 0.3898460 8.023597 0.1021042 0.0000000 0.1444333 0.14443333 1.755501e-08 3.565577e-17 FALSE TRUE
MSTRG.4377.3 ENSG00000095564 HEK293_OSMI2_6hA HEK293_TMG_6hB BTAF1 protein_coding   10.0304 3.766125 17.8833 0.2893856 0.552944 2.244441 0.7322453 1.3541561 0.000000 0.2925500 0.0000000 -7.091865 0.1922833 0.3568667 0.0000000 -0.35686667 3.565577e-17 3.565577e-17 FALSE TRUE
MSTRG.4377.5 ENSG00000095564 HEK293_OSMI2_6hA HEK293_TMG_6hB BTAF1 protein_coding   10.0304 3.766125 17.8833 0.2893856 0.552944 2.244441 2.2964671 0.6493252 5.139372 0.3725992 0.4323147 2.965334 0.1610542 0.1617333 0.2868000 0.12506667 5.791090e-01 3.565577e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000095564 E001 2.8537650 0.0763274447 3.299853e-01 5.689449e-01 10 91923770 91923807 38 + 0.540 0.359 -0.941
ENSG00000095564 E002 7.4368560 0.1628316133 4.506172e-01 6.661387e-01 10 91923808 91923846 39 + 0.871 0.691 -0.716
ENSG00000095564 E003 7.9731926 0.1677599026 9.242460e-01 9.644955e-01 10 91923847 91923867 21 + 0.871 0.839 -0.121
ENSG00000095564 E004 7.5980840 0.1593380123 6.157014e-01 7.808002e-01 10 91923868 91923873 6 + 0.870 0.744 -0.499
ENSG00000095564 E005 23.3737622 0.0421366041 7.207627e-01 8.486531e-01 10 91923874 91924090 217 + 1.298 1.292 -0.022
ENSG00000095564 E006 32.5633052 0.0074336953 1.227030e-01 3.200138e-01 10 91935657 91935780 124 + 1.452 1.368 -0.290
ENSG00000095564 E007 46.9557338 0.0033709657 1.002762e-02 5.827731e-02 10 91939952 91940066 115 + 1.615 1.482 -0.452
ENSG00000095564 E008 63.9236095 0.0077722127 8.886619e-05 1.353787e-03 10 91942422 91942568 147 + 1.762 1.525 -0.805
ENSG00000095564 E009 28.7650426 0.0124377505 5.801210e-03 3.875112e-02 10 91951403 91951408 6 + 1.424 1.195 -0.801
ENSG00000095564 E010 92.1982136 0.0037060091 1.517755e-03 1.373787e-02 10 91951409 91951566 158 + 1.903 1.780 -0.414
ENSG00000095564 E011 95.2022464 0.0024206286 2.154715e-03 1.810680e-02 10 91953737 91953873 137 + 1.913 1.807 -0.357
ENSG00000095564 E012 74.4847455 0.0024354630 3.436266e-03 2.597165e-02 10 91956528 91956620 93 + 1.811 1.695 -0.393
ENSG00000095564 E013 47.3843964 0.0008688281 7.775046e-07 2.282818e-05 10 91956621 91956657 37 + 1.647 1.344 -1.041
ENSG00000095564 E014 63.1952950 0.0013281090 2.574388e-08 1.101235e-06 10 91957225 91957293 69 + 1.768 1.464 -1.038
ENSG00000095564 E015 82.8679650 0.0005422566 1.076252e-06 3.030907e-05 10 91959065 91959154 90 + 1.869 1.666 -0.688
ENSG00000095564 E016 26.8044003 0.0102775630 2.051552e-03 1.740611e-02 10 91959155 91959282 128 + 1.271 1.586 1.089
ENSG00000095564 E017 73.9113520 0.0005161685 3.423055e-04 4.161453e-03 10 91959785 91959880 96 + 1.812 1.672 -0.476
ENSG00000095564 E018 80.4239899 0.0073889918 7.073049e-03 4.495875e-02 10 91959978 91960154 177 + 1.846 1.716 -0.440
ENSG00000095564 E019 66.4947631 0.0007225021 3.414401e-01 5.793224e-01 10 91962538 91962678 141 + 1.744 1.742 -0.006
ENSG00000095564 E020 83.2259336 0.0005157799 5.609409e-01 7.439798e-01 10 91964077 91964201 125 + 1.835 1.856 0.073
ENSG00000095564 E021 43.3244565 0.0010053479 9.530782e-01 9.785056e-01 10 91966637 91966643 7 + 1.549 1.601 0.179
ENSG00000095564 E022 83.8437134 0.0005797702 2.016073e-01 4.316522e-01 10 91966644 91966757 114 + 1.844 1.833 -0.037
ENSG00000095564 E023 61.0374957 0.0006544642 2.200323e-01 4.535545e-01 10 91980454 91980519 66 + 1.708 1.689 -0.064
ENSG00000095564 E024 47.9425117 0.0007540102 4.467616e-01 6.632668e-01 10 91980520 91980558 39 + 1.600 1.601 0.005
ENSG00000095564 E025 68.4727536 0.0024796986 9.410559e-01 9.727741e-01 10 91981643 91981792 150 + 1.744 1.789 0.154
ENSG00000095564 E026 75.6412999 0.0057519292 5.021753e-01 7.022897e-01 10 91982083 91982225 143 + 1.775 1.866 0.306
ENSG00000095564 E027 0.0000000       10 91982226 91982415 190 +      
ENSG00000095564 E028 87.2459758 0.0036721145 1.073542e-01 2.945983e-01 10 91982587 91982761 175 + 1.863 1.824 -0.131
ENSG00000095564 E029 102.8045651 0.0016693639 1.923825e-03 1.656071e-02 10 91984201 91984404 204 + 1.944 1.845 -0.333
ENSG00000095564 E030 162.2748357 0.0125279715 6.217469e-02 2.076888e-01 10 91989154 91989580 427 + 2.134 2.073 -0.203
ENSG00000095564 E031 100.9350164 0.0030305331 6.090719e-01 7.762665e-01 10 91992119 91992309 191 + 1.913 1.937 0.083
ENSG00000095564 E032 78.8443452 0.0023558570 8.456695e-01 9.224919e-01 10 91993694 91993847 154 + 1.803 1.841 0.127
ENSG00000095564 E033 66.5723372 0.0239865096 9.635156e-01 9.837004e-01 10 91994535 91994644 110 + 1.727 1.777 0.169
ENSG00000095564 E034 92.6856823 0.0047122924 6.396398e-01 7.966985e-01 10 91996369 91996570 202 + 1.876 1.904 0.093
ENSG00000095564 E035 88.9291080 0.0063796634 1.656734e-01 3.847174e-01 10 91997603 91997751 149 + 1.871 1.842 -0.098
ENSG00000095564 E036 95.7002095 0.0036036411 4.554544e-01 6.698650e-01 10 92008123 92008275 153 + 1.894 1.906 0.040
ENSG00000095564 E037 69.1970263 0.0011958276 8.622271e-01 9.315638e-01 10 92008829 92008950 122 + 1.749 1.789 0.136
ENSG00000095564 E038 97.7367960 0.0004441737 2.689786e-03 2.151107e-02 10 92009041 92009208 168 + 1.923 1.837 -0.289
ENSG00000095564 E039 72.6304978 0.0007012324 1.454719e-01 3.556137e-01 10 92011073 92011150 78 + 1.783 1.757 -0.087
ENSG00000095564 E040 79.2043615 0.0059410956 5.768778e-01 7.550452e-01 10 92011286 92011415 130 + 1.795 1.876 0.273
ENSG00000095564 E041 87.7437456 0.0056794920 6.343284e-01 7.931405e-01 10 92013667 92013808 142 + 1.842 1.919 0.259
ENSG00000095564 E042 88.7127379 0.0005256849 8.667604e-02 2.576674e-01 10 92013899 92014029 131 + 1.836 1.959 0.415
ENSG00000095564 E043 90.3144980 0.0005117560 8.556007e-01 9.279823e-01 10 92016340 92016465 126 + 1.861 1.918 0.191
ENSG00000095564 E044 117.1671924 0.0003273030 4.785072e-02 1.746627e-01 10 92018783 92018935 153 + 1.955 2.078 0.413
ENSG00000095564 E045 133.7885118 0.0004717590 5.040458e-02 1.806204e-01 10 92024756 92024967 212 + 2.013 2.132 0.399
ENSG00000095564 E046 129.1602069 0.0020685836 2.151933e-02 1.010374e-01 10 92026592 92026751 160 + 1.991 2.134 0.481
ENSG00000095564 E047 125.3729111 0.0043284549 4.285240e-05 7.297756e-04 10 92027130 92027300 171 + 1.953 2.187 0.783
ENSG00000095564 E048 79.5153607 1.2869599242 3.286958e-01 5.676814e-01 10 92028790 92028929 140 + 1.704 2.087 1.289
ENSG00000095564 E049 289.4863470 1.7226657007 3.568574e-01 5.931932e-01 10 92028930 92031469 2540 + 2.248 2.662 1.381
ENSG00000095564 E050 2.5097697 0.1597812161 3.269061e-02 1.351943e-01 10 92031568 92031744 177 + 0.330 0.795 2.205
ENSG00000095564 E051 0.1723744 0.0313415196 1.253714e-01   10 92052186 92052439 254 + 0.000 0.215 11.439