ENSG00000095397

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265134 ENSG00000095397 HEK293_OSMI2_6hA HEK293_TMG_6hB WHRN protein_coding protein_coding 7.937044 13.32457 5.336628 0.9122815 0.1206108 -1.31847 3.2273893 5.5564226 2.3266283 1.0111190 0.16305027 -1.2523222 0.41150000 0.41816667 0.43513333 0.01696667 0.976842850 0.008659243 FALSE TRUE
ENST00000374057 ENSG00000095397 HEK293_OSMI2_6hA HEK293_TMG_6hB WHRN protein_coding protein_coding 7.937044 13.32457 5.336628 0.9122815 0.1206108 -1.31847 0.6051211 1.4268509 0.1285375 0.1853748 0.05668747 -3.3745621 0.06952083 0.10623333 0.02396667 -0.08226667 0.008659243 0.008659243 FALSE TRUE
ENST00000673811 ENSG00000095397 HEK293_OSMI2_6hA HEK293_TMG_6hB WHRN protein_coding retained_intron 7.937044 13.32457 5.336628 0.9122815 0.1206108 -1.31847 1.0360403 1.6460979 1.1043451 0.1220234 0.06681562 -0.5715919 0.14230417 0.12453333 0.20660000 0.08206667 0.162953857 0.008659243 TRUE TRUE
ENST00000674036 ENSG00000095397 HEK293_OSMI2_6hA HEK293_TMG_6hB WHRN protein_coding protein_coding 7.937044 13.32457 5.336628 0.9122815 0.1206108 -1.31847 0.6445416 1.1320446 0.0000000 0.5673176 0.00000000 -6.8354752 0.06812917 0.08143333 0.00000000 -0.08143333 0.385360943 0.008659243 FALSE TRUE
ENST00000674048 ENSG00000095397 HEK293_OSMI2_6hA HEK293_TMG_6hB WHRN protein_coding retained_intron 7.937044 13.32457 5.336628 0.9122815 0.1206108 -1.31847 0.9884928 1.1492555 0.8048345 0.9498172 0.06396356 -0.5086195 0.12677500 0.08816667 0.15056667 0.06240000 0.633156033 0.008659243 FALSE TRUE
MSTRG.33271.3 ENSG00000095397 HEK293_OSMI2_6hA HEK293_TMG_6hB WHRN protein_coding   7.937044 13.32457 5.336628 0.9122815 0.1206108 -1.31847 0.6013245 1.5014935 0.2613135 0.3413683 0.07876821 -2.4779418 0.07254583 0.11450000 0.04903333 -0.06546667 0.448532698 0.008659243 FALSE TRUE
MSTRG.33271.7 ENSG00000095397 HEK293_OSMI2_6hA HEK293_TMG_6hB WHRN protein_coding   7.937044 13.32457 5.336628 0.9122815 0.1206108 -1.31847 0.3882126 0.5052405 0.2883276 0.2083202 0.14840107 -0.7883484 0.05191250 0.03666667 0.05280000 0.01613333 0.984803156 0.008659243 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000095397 E001 0.1426347 0.0325065891 0.146861063   9 114402080 114402080 1 - 0.199 0.000 -11.748
ENSG00000095397 E002 8.8725731 0.0140108300 0.775012015 0.88177411 9 114402081 114402144 64 - 0.903 0.922 0.073
ENSG00000095397 E003 77.0118870 0.0005820873 0.206540661 0.43757772 9 114402145 114402475 331 - 1.785 1.829 0.147
ENSG00000095397 E004 74.5469335 0.0065862403 0.672178838 0.81769777 9 114402476 114402560 85 - 1.837 1.791 -0.153
ENSG00000095397 E005 137.1917778 0.0003804754 0.688227554 0.82798979 9 114402561 114402936 376 - 2.091 2.062 -0.098
ENSG00000095397 E006 69.9761250 0.0005481145 0.937947084 0.97124400 9 114403217 114403339 123 - 1.790 1.778 -0.040
ENSG00000095397 E007 92.4995000 0.0004672010 0.021097606 0.09966729 9 114403896 114404074 179 - 1.833 1.917 0.284
ENSG00000095397 E008 31.1518240 0.0014073007 0.018551145 0.09089472 9 114404075 114404077 3 - 1.306 1.473 0.580
ENSG00000095397 E009 101.0776494 0.0009127721 0.411639146 0.63727425 9 114406355 114406640 286 - 1.923 1.941 0.060
ENSG00000095397 E010 79.4094066 0.0007504396 0.592438781 0.76521494 9 114406641 114406892 252 - 1.832 1.842 0.032
ENSG00000095397 E011 44.5006128 0.0009781382 0.327365619 0.56646707 9 114407947 114408018 72 - 1.556 1.601 0.155
ENSG00000095397 E012 2.0754620 0.0627447163 0.156232341 0.37125010 9 114420037 114420069 33 - 0.199 0.497 1.882
ENSG00000095397 E013 60.0863375 0.0006341435 0.209974189 0.44180799 9 114423314 114423523 210 - 1.777 1.698 -0.266
ENSG00000095397 E014 74.4345989 0.0008043901 0.152276143 0.36569315 9 114424334 114424546 213 - 1.872 1.791 -0.272
ENSG00000095397 E015 34.0364828 0.0164529904 0.007582065 0.04740654 9 114424988 114425024 37 - 1.650 1.414 -0.809
ENSG00000095397 E016 76.5786049 0.0422358555 0.011247889 0.06339485 9 114425025 114426210 1186 - 2.003 1.739 -0.886
ENSG00000095397 E017 65.3983135 0.0059771330 0.021623857 0.10137276 9 114426211 114426413 203 - 1.865 1.715 -0.505
ENSG00000095397 E018 50.3482592 0.0010559212 0.324606205 0.56387553 9 114466267 114466392 126 - 1.693 1.622 -0.242
ENSG00000095397 E019 7.8712002 0.0148829965 0.005014074 0.03469725 9 114478321 114478552 232 - 0.522 0.969 1.836
ENSG00000095397 E020 76.0903624 0.0099978894 0.937902765 0.97122867 9 114478553 114478771 219 - 1.833 1.811 -0.074
ENSG00000095397 E021 0.4646582 0.0217681645 0.703963885   9 114503107 114503173 67 - 0.199 0.133 -0.707
ENSG00000095397 E022 0.5953387 0.0532771842 0.312604171   9 114503551 114503699 149 - 0.000 0.233 10.300
ENSG00000095397 E023 89.7309475 0.0098928402 0.700340712 0.83585449 9 114504184 114504739 556 - 1.882 1.886 0.011
ENSG00000095397 E024 26.8656318 0.0077943898 0.003113887 0.02409705 9 114504740 114504917 178 - 1.159 1.425 0.931
ENSG00000095397 E025 27.0217611 0.0016249407 0.064323690 0.21240651 9 114504918 114505015 98 - 1.267 1.403 0.475
ENSG00000095397 E026 23.5780789 0.0014986975 0.039823338 0.15428423 9 114505016 114505051 36 - 1.192 1.357 0.580
ENSG00000095397 E027 20.0085130 0.0066748380 0.066824638 0.21791150 9 114505052 114505194 143 - 1.122 1.294 0.609
ENSG00000095397 E028 41.0695072 0.0009293048 0.048238064 0.17555897 9 114505195 114506325 1131 - 1.462 1.577 0.395