ENSG00000094975

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263688 ENSG00000094975 HEK293_OSMI2_6hA HEK293_TMG_6hB SUCO protein_coding protein_coding 10.56613 3.366328 18.0752 0.5977792 0.6475395 2.421282 2.492938 0.6355856 3.1961477 0.3195887 0.41589728 2.312161 0.1864875 0.23370000 0.17600000 -0.05770000 1.000000e+00 1.222623e-15 FALSE TRUE
ENST00000609685 ENSG00000094975 HEK293_OSMI2_6hA HEK293_TMG_6hB SUCO protein_coding retained_intron 10.56613 3.366328 18.0752 0.5977792 0.6475395 2.421282 1.115132 1.3083781 0.2966518 0.3824707 0.06207515 -2.104091 0.2608542 0.37623333 0.01636667 -0.35986667 1.222623e-15 1.222623e-15 FALSE FALSE
ENST00000616058 ENSG00000094975 HEK293_OSMI2_6hA HEK293_TMG_6hB SUCO protein_coding protein_coding 10.56613 3.366328 18.0752 0.5977792 0.6475395 2.421282 1.707195 0.5319886 3.4551770 0.1400707 0.16167972 2.676595 0.1428042 0.15776667 0.19233333 0.03456667 8.389947e-01 1.222623e-15 FALSE TRUE
MSTRG.2600.7 ENSG00000094975 HEK293_OSMI2_6hA HEK293_TMG_6hB SUCO protein_coding   10.56613 3.366328 18.0752 0.5977792 0.6475395 2.421282 3.725009 0.5500509 7.9376842 0.2173643 0.45895195 3.826905 0.2787500 0.14856667 0.43843333 0.28986667 2.609100e-02 1.222623e-15 FALSE TRUE
MSTRG.2600.9 ENSG00000094975 HEK293_OSMI2_6hA HEK293_TMG_6hB SUCO protein_coding   10.56613 3.366328 18.0752 0.5977792 0.6475395 2.421282 1.034332 0.2476520 2.4937117 0.2476520 0.31264001 3.280573 0.0831625 0.05693333 0.13756667 0.08063333 4.305395e-01 1.222623e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000094975 E001 0.0000000       1 172532349 172532472 124 +      
ENSG00000094975 E002 0.0000000       1 172532473 172532798 326 +      
ENSG00000094975 E003 0.0000000       1 172532799 172532799 1 +      
ENSG00000094975 E004 7.4420964 0.0038781106 7.185034e-01 0.847302905 1 172533118 172533149 32 + 0.769 0.796 0.110
ENSG00000094975 E005 9.1629191 0.0034431742 5.893599e-01 0.763258658 1 172533150 172533176 27 + 0.826 0.989 0.618
ENSG00000094975 E006 7.2160014 0.0039744886 2.042740e-01 0.435000503 1 172533177 172533177 1 + 0.722 0.989 1.034
ENSG00000094975 E007 8.1683033 0.0037359239 2.153753e-01 0.447926703 1 172533178 172533182 5 + 0.769 1.026 0.983
ENSG00000094975 E008 9.6072036 0.0031621435 4.735956e-01 0.682508067 1 172533183 172533212 30 + 0.841 1.026 0.697
ENSG00000094975 E009 27.2525192 0.0023237790 1.578597e-01 0.373524140 1 172533213 172533382 170 + 1.243 1.463 0.763
ENSG00000094975 E010 37.4324587 0.0060584743 7.059444e-01 0.839323192 1 172533383 172533497 115 + 1.399 1.463 0.222
ENSG00000094975 E011 45.0358603 0.0012697046 2.780744e-01 0.518181424 1 172551512 172551626 115 + 1.485 1.501 0.054
ENSG00000094975 E012 2.0189560 0.0490494076 3.643206e-01 0.599271713 1 172551627 172552152 526 + 0.315 0.563 1.316
ENSG00000094975 E013 32.5973624 0.0013170291 3.757040e-02 0.148501183 1 172553260 172553329 70 + 1.363 1.267 -0.335
ENSG00000094975 E014 26.0693856 0.0014054213 6.164865e-02 0.206500301 1 172553330 172553370 41 + 1.272 1.176 -0.337
ENSG00000094975 E015 62.7402241 0.0006702320 1.970471e-03 0.016868194 1 172555869 172556023 155 + 1.637 1.524 -0.387
ENSG00000094975 E016 62.9559719 0.0065784142 1.614520e-03 0.014428382 1 172557280 172557417 138 + 1.640 1.489 -0.515
ENSG00000094975 E017 73.2696726 0.0025563159 7.918553e-05 0.001230557 1 172557644 172557794 151 + 1.709 1.535 -0.592
ENSG00000094975 E018 33.2959607 0.0142507807 3.683416e-03 0.027386230 1 172569019 172569026 8 + 1.380 1.149 -0.815
ENSG00000094975 E019 62.3288108 0.0059600373 7.555468e-04 0.007905110 1 172569027 172569142 116 + 1.640 1.474 -0.567
ENSG00000094975 E020 57.8851984 0.0007784769 7.836504e-04 0.008143548 1 172570047 172570171 125 + 1.608 1.463 -0.497
ENSG00000094975 E021 0.0000000       1 172570172 172570513 342 +      
ENSG00000094975 E022 39.5753921 0.0070012573 1.857353e-02 0.090983415 1 172570663 172570730 68 + 1.445 1.324 -0.417
ENSG00000094975 E023 0.5421338 0.0234663077 3.851138e-01   1 172570731 172570796 66 + 0.093 0.274 1.883
ENSG00000094975 E024 44.4227425 0.0103950025 5.087732e-02 0.181748432 1 172573891 172573998 108 + 1.487 1.407 -0.278
ENSG00000094975 E025 58.9292926 0.0240775226 1.002438e-01 0.282227955 1 172575518 172575623 106 + 1.604 1.535 -0.237
ENSG00000094975 E026 19.4873643 0.0387754520 8.251650e-01 0.911018750 1 172577539 172577559 21 + 1.121 1.245 0.443
ENSG00000094975 E027 51.1939704 0.0239938383 9.225081e-02 0.267923063 1 172577764 172577819 56 + 1.546 1.464 -0.279
ENSG00000094975 E028 57.7045754 0.0096565318 3.756701e-02 0.148493865 1 172578298 172578389 92 + 1.596 1.523 -0.250
ENSG00000094975 E029 44.7843818 0.0138284141 3.019234e-01 0.542473829 1 172579202 172579267 66 + 1.481 1.487 0.021
ENSG00000094975 E030 37.3779356 0.0009732090 4.193146e-01 0.643141416 1 172585018 172585086 69 + 1.404 1.436 0.110
ENSG00000094975 E031 50.7802460 0.0049283551 1.124220e-01 0.303166130 1 172585858 172585948 91 + 1.539 1.512 -0.090
ENSG00000094975 E032 78.1662715 0.0156812314 2.172903e-01 0.450181109 1 172588760 172588924 165 + 1.718 1.719 0.002
ENSG00000094975 E033 27.6020449 0.0252484007 1.086967e-01 0.296924372 1 172588925 172588930 6 + 1.293 1.197 -0.340
ENSG00000094975 E034 265.8764823 0.0085023215 3.567457e-02 0.143383005 1 172588931 172589926 996 + 2.244 2.242 -0.007
ENSG00000094975 E035 66.7817137 0.0056895772 9.272094e-01 0.965648107 1 172590984 172591071 88 + 1.635 1.743 0.365
ENSG00000094975 E036 53.6618966 0.0007831644 9.087135e-01 0.956446421 1 172600064 172600168 105 + 1.545 1.651 0.362
ENSG00000094975 E037 46.9436083 0.0009289524 7.463709e-01 0.864621725 1 172602064 172602148 85 + 1.485 1.607 0.414
ENSG00000094975 E038 50.0941548 0.0024453225 6.582269e-01 0.808860350 1 172602149 172602218 70 + 1.520 1.587 0.231
ENSG00000094975 E039 63.8232574 0.0012778882 8.998394e-01 0.951815828 1 172602696 172602787 92 + 1.622 1.714 0.313
ENSG00000094975 E040 2.3551626 0.0597320077 9.735438e-01 0.988686435 1 172602788 172603205 418 + 0.387 0.441 0.297
ENSG00000094975 E041 2.4981572 0.0224590242 2.353431e-01 0.471261446 1 172608313 172608746 434 + 0.363 0.655 1.430
ENSG00000094975 E042 58.2208455 0.0007802940 5.463639e-01 0.733717283 1 172608747 172608802 56 + 1.578 1.714 0.464
ENSG00000094975 E043 410.8478566 0.3623581163 6.420045e-02 0.212143924 1 172609816 172611833 2018 + 2.350 2.778 1.425