ENSG00000094916

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000209875 ENSG00000094916 HEK293_OSMI2_6hA HEK293_TMG_6hB CBX5 protein_coding protein_coding 33.86521 25.64444 33.87757 4.428498 1.385174 0.401548 23.275611 21.5364011 21.690509 3.93860056 1.2537784 0.01028199 0.7004292 0.837666667 0.63936667 -0.19830000 1.921813e-06 1.921813e-06 FALSE TRUE
ENST00000439541 ENSG00000094916 HEK293_OSMI2_6hA HEK293_TMG_6hB CBX5 protein_coding protein_coding 33.86521 25.64444 33.87757 4.428498 1.385174 0.401548 1.753030 0.1899706 2.460146 0.08468828 0.2752713 3.62673616 0.0437625 0.008933333 0.07293333 0.06400000 8.439167e-03 1.921813e-06 FALSE TRUE
MSTRG.7409.4 ENSG00000094916 HEK293_OSMI2_6hA HEK293_TMG_6hB CBX5 protein_coding   33.86521 25.64444 33.87757 4.428498 1.385174 0.401548 4.830282 0.9436025 6.719658 0.55897499 0.1952217 2.81907316 0.1269333 0.036233333 0.19936667 0.16313333 3.006520e-01 1.921813e-06 FALSE TRUE
MSTRG.7409.9 ENSG00000094916 HEK293_OSMI2_6hA HEK293_TMG_6hB CBX5 protein_coding   33.86521 25.64444 33.87757 4.428498 1.385174 0.401548 2.933564 2.3713744 1.884316 0.53913328 0.4155425 -0.33011775 0.0968500 0.091566667 0.05510000 -0.03646667 4.322989e-01 1.921813e-06 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000094916 E001 475.9499839 1.401303599 2.301241e-01 0.4652785448 12 54230942 54231396 455 - 2.263 2.910 2.157
ENSG00000094916 E002 4961.9158864 0.025169283 2.164576e-02 0.1014306460 12 54231397 54240624 9228 - 3.568 3.806 0.788
ENSG00000094916 E003 482.0479112 0.026788881 9.276963e-06 0.0001966353 12 54240625 54241746 1122 - 2.752 2.586 -0.554
ENSG00000094916 E004 82.1794480 0.011802029 2.114874e-02 0.0998177381 12 54241747 54241754 8 - 1.907 1.931 0.079
ENSG00000094916 E005 198.6351304 0.019729071 8.156882e-03 0.0500487633 12 54241755 54241905 151 - 2.304 2.294 -0.034
ENSG00000094916 E006 187.0247600 0.030715780 6.606021e-03 0.0427307970 12 54246115 54246212 98 - 2.299 2.242 -0.191
ENSG00000094916 E007 114.8131453 0.021136461 2.965487e-03 0.0231917044 12 54246213 54246215 3 - 2.086 2.033 -0.177
ENSG00000094916 E008 155.6727514 0.020394175 4.803673e-04 0.0054978717 12 54252041 54252090 50 - 2.230 2.148 -0.273
ENSG00000094916 E009 217.8362052 0.014674285 1.665374e-04 0.0022950483 12 54252091 54252227 137 - 2.365 2.306 -0.199
ENSG00000094916 E010 0.1723744 0.036816262 5.982988e-01   12 54252228 54252525 298 - 0.000 0.131 11.488
ENSG00000094916 E011 238.9472124 0.023782729 7.235211e-03 0.0457516085 12 54257514 54257692 179 - 2.392 2.362 -0.099
ENSG00000094916 E012 0.0000000       12 54258069 54258427 359 -      
ENSG00000094916 E013 1.6601553 0.032707342 3.682605e-01 0.6025949460 12 54259270 54259508 239 - 0.443 0.382 -0.330
ENSG00000094916 E014 5.2329715 0.082141125 1.937059e-01 0.4217398830 12 54259509 54259592 84 - 0.839 0.745 -0.371
ENSG00000094916 E015 27.8979194 0.068729356 3.509647e-02 0.1418349357 12 54271841 54273680 1840 - 1.516 1.391 -0.428
ENSG00000094916 E016 44.1380878 0.002490378 9.022747e-01 0.9530136376 12 54273681 54274309 629 - 1.567 1.723 0.529
ENSG00000094916 E017 4.7392027 0.076826835 6.611280e-01 0.8106245387 12 54274310 54274341 32 - 0.633 0.849 0.880
ENSG00000094916 E018 147.2539863 0.020846366 3.329503e-02 0.1368639937 12 54280008 54280155 148 - 2.161 2.178 0.059