ENSG00000094841

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373379 ENSG00000094841 HEK293_OSMI2_6hA HEK293_TMG_6hB UPRT protein_coding protein_coding 4.949084 2.623426 6.600201 0.05401028 0.2113684 1.327753 0.7312871 0.4580827 0.8458993 0.02099787 0.16994962 0.8706776 0.14165000 0.1745333 0.12793333 -0.04660000 0.766291675 0.001932323 FALSE  
ENST00000373383 ENSG00000094841 HEK293_OSMI2_6hA HEK293_TMG_6hB UPRT protein_coding protein_coding 4.949084 2.623426 6.600201 0.05401028 0.2113684 1.327753 3.5606361 1.8188795 5.2970118 0.20783691 0.28072010 1.5369397 0.71617917 0.6970000 0.80276667 0.10576667 0.775211775 0.001932323 FALSE  
ENST00000462237 ENSG00000094841 HEK293_OSMI2_6hA HEK293_TMG_6hB UPRT protein_coding nonsense_mediated_decay 4.949084 2.623426 6.600201 0.05401028 0.2113684 1.327753 0.3185030 0.0000000 0.3846426 0.00000000 0.05538652 5.3024747 0.05627083 0.0000000 0.05813333 0.05813333 0.001932323 0.001932323 TRUE  
ENST00000530743 ENSG00000094841 HEK293_OSMI2_6hA HEK293_TMG_6hB UPRT protein_coding protein_coding 4.949084 2.623426 6.600201 0.05401028 0.2113684 1.327753 0.2527684 0.2811040 0.0000000 0.28110396 0.00000000 -4.8634626 0.06225833 0.1029667 0.00000000 -0.10296667 0.801087111 0.001932323 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000094841 E001 0.0000000       X 75156388 75156550 163 +      
ENSG00000094841 E002 0.0000000       X 75160550 75160671 122 +      
ENSG00000094841 E003 0.0000000       X 75163132 75163225 94 +      
ENSG00000094841 E004 0.0000000       X 75167806 75167879 74 +      
ENSG00000094841 E005 0.1308682 0.0313716195 0.211041851   X 75274085 75274089 5 + 0.000 0.172 10.703
ENSG00000094841 E006 6.8950525 0.0047316044 0.975537551 0.98957848 X 75274090 75274115 26 + 0.870 0.865 -0.019
ENSG00000094841 E007 10.9169076 0.0029255396 0.654898487 0.80667382 X 75274116 75274126 11 + 1.060 1.011 -0.180
ENSG00000094841 E008 70.5029857 0.0105668014 0.905617144 0.95493766 X 75274127 75274640 514 + 1.823 1.822 -0.003
ENSG00000094841 E009 0.4161375 0.1119460717 0.902657523   X 75274728 75274758 31 + 0.154 0.171 0.187
ENSG00000094841 E010 0.0000000       X 75285434 75285524 91 +      
ENSG00000094841 E011 0.0000000       X 75291024 75291076 53 +      
ENSG00000094841 E012 0.1723744 0.0310246973 0.211043811   X 75291393 75291560 168 + 0.000 0.172 12.587
ENSG00000094841 E013 0.7616940 0.0470697994 0.621790196   X 75291675 75291747 73 + 0.268 0.172 -0.805
ENSG00000094841 E014 25.9386305 0.0015929791 0.276934854 0.51695582 X 75293472 75293514 43 + 1.422 1.341 -0.280
ENSG00000094841 E015 2.0354221 0.0099796771 0.004358242 0.03114369 X 75294563 75294620 58 + 0.577 0.000 -15.393
ENSG00000094841 E016 36.4461984 0.0024552267 0.078785154 0.24239159 X 75296342 75296411 70 + 1.574 1.459 -0.394
ENSG00000094841 E017 35.0496784 0.0010746223 0.318071327 0.55800586 X 75297491 75297553 63 + 1.544 1.480 -0.219
ENSG00000094841 E018 0.3088520 0.0274783349 0.546906212   X 75297554 75297791 238 + 0.084 0.172 1.183
ENSG00000094841 E019 44.7114991 0.0012159747 0.861132913 0.93096462 X 75299735 75299896 162 + 1.628 1.617 -0.038
ENSG00000094841 E020 39.4457142 0.0016588588 0.353230433 0.59017002 X 75300867 75300965 99 + 1.590 1.533 -0.194
ENSG00000094841 E021 4.9798660 0.0052606610 0.552654821 0.73814374 X 75300966 75301015 50 + 0.722 0.803 0.325
ENSG00000094841 E022 151.1340928 0.0005495069 0.002685458 0.02148649 X 75303405 75304885 1481 + 2.121 2.196 0.249