ENSG00000093167

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000421276 ENSG00000093167 HEK293_OSMI2_6hA HEK293_TMG_6hB LRRFIP2 protein_coding protein_coding 31.66559 26.6451 33.75021 5.049836 0.7159699 0.3409122 12.555353 12.0324218 13.7071067 2.36182781 0.63486556 0.1878507 0.40774167 0.45400000 0.40580000 -0.04820000 8.230353e-01 4.292432e-05 FALSE TRUE
ENST00000490597 ENSG00000093167 HEK293_OSMI2_6hA HEK293_TMG_6hB LRRFIP2 protein_coding processed_transcript 31.66559 26.6451 33.75021 5.049836 0.7159699 0.3409122 1.905022 0.6352677 2.4008470 0.11804503 0.30336626 1.9015703 0.05517500 0.02406667 0.07083333 0.04676667 1.273110e-03 4.292432e-05   FALSE
ENST00000496825 ENSG00000093167 HEK293_OSMI2_6hA HEK293_TMG_6hB LRRFIP2 protein_coding processed_transcript 31.66559 26.6451 33.75021 5.049836 0.7159699 0.3409122 2.453699 2.5870360 2.0255395 0.79767994 0.05121567 -0.3514548 0.07953333 0.09466667 0.06003333 -0.03463333 4.001643e-01 4.292432e-05   FALSE
MSTRG.22700.13 ENSG00000093167 HEK293_OSMI2_6hA HEK293_TMG_6hB LRRFIP2 protein_coding   31.66559 26.6451 33.75021 5.049836 0.7159699 0.3409122 3.434260 3.1109408 5.5916910 0.78773973 0.66891181 0.8438814 0.10820000 0.11320000 0.16566667 0.05246667 4.613236e-01 4.292432e-05 FALSE TRUE
MSTRG.22700.25 ENSG00000093167 HEK293_OSMI2_6hA HEK293_TMG_6hB LRRFIP2 protein_coding   31.66559 26.6451 33.75021 5.049836 0.7159699 0.3409122 1.888894 0.5329175 2.3875370 0.09905292 0.39058319 2.1427482 0.05244167 0.02003333 0.07036667 0.05033333 5.492773e-04 4.292432e-05   FALSE
MSTRG.22700.31 ENSG00000093167 HEK293_OSMI2_6hA HEK293_TMG_6hB LRRFIP2 protein_coding   31.66559 26.6451 33.75021 5.049836 0.7159699 0.3409122 2.131136 3.0512030 0.7868992 0.81179446 0.13284782 -1.9416295 0.07362083 0.11033333 0.02336667 -0.08696667 4.292432e-05 4.292432e-05   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000093167 E001 0.9818539 0.0183705575 9.722098e-01   3 37052626 37052655 30 - 0.290 0.298 0.048
ENSG00000093167 E002 13.1819638 0.0189735448 9.749975e-01 9.893672e-01 3 37052656 37053003 348 - 1.158 1.156 -0.007
ENSG00000093167 E003 221.2053148 0.0027412660 6.254086e-02 2.084732e-01 3 37053004 37053605 602 - 2.315 2.374 0.195
ENSG00000093167 E004 92.4846371 0.0017327972 2.853451e-03 2.251861e-02 3 37053606 37053686 81 - 1.904 2.026 0.407
ENSG00000093167 E005 57.8361847 0.0007572464 9.020002e-02 2.641451e-01 3 37053687 37053720 34 - 1.729 1.808 0.267
ENSG00000093167 E006 62.8064996 0.0019638966 2.906223e-01 5.312831e-01 3 37053721 37053749 29 - 1.778 1.830 0.173
ENSG00000093167 E007 212.4113176 0.0003134552 1.106181e-02 6.262876e-02 3 37053750 37053961 212 - 2.300 2.362 0.206
ENSG00000093167 E008 190.4885592 0.0002627937 7.069832e-02 2.261409e-01 3 37054411 37054515 105 - 2.262 2.308 0.152
ENSG00000093167 E009 174.1427749 0.0007119610 2.821434e-02 1.219135e-01 3 37055086 37055165 80 - 2.213 2.275 0.207
ENSG00000093167 E010 161.6746855 0.0002754661 1.777047e-01 4.007269e-01 3 37058790 37058858 69 - 2.194 2.231 0.123
ENSG00000093167 E011 138.2283535 0.0003497099 9.449598e-01 9.747730e-01 3 37058859 37058910 52 - 2.147 2.144 -0.010
ENSG00000093167 E012 140.9904739 0.0003427842 3.981475e-01 6.268278e-01 3 37063742 37063791 50 - 2.168 2.143 -0.087
ENSG00000093167 E013 7.2445172 0.0043920027 6.479322e-01 8.021769e-01 3 37063792 37065334 1543 - 0.935 0.879 -0.211
ENSG00000093167 E014 168.7015790 0.0002778189 5.720788e-01 7.517654e-01 3 37065810 37065942 133 - 2.224 2.239 0.048
ENSG00000093167 E015 7.6634802 0.0885853090 7.821577e-01 8.859534e-01 3 37065943 37066223 281 - 0.970 0.897 -0.275
ENSG00000093167 E016 7.4064281 0.0193158353 7.009415e-01 8.362267e-01 3 37066224 37066325 102 - 0.951 0.897 -0.205
ENSG00000093167 E017 35.1524526 0.0790291462 3.273270e-02 1.353076e-01 3 37066326 37068763 2438 - 1.687 1.369 -1.090
ENSG00000093167 E018 3.0487807 0.0080336541 5.570375e-01 7.411644e-01 3 37072790 37072846 57 - 0.652 0.560 -0.407
ENSG00000093167 E019 2.8211084 0.0077626998 3.936225e-01 6.232277e-01 3 37072847 37072882 36 - 0.652 0.518 -0.602
ENSG00000093167 E020 146.5906543 0.0003296322 4.080494e-01 6.345107e-01 3 37075024 37075116 93 - 2.185 2.160 -0.082
ENSG00000093167 E021 88.7037700 0.0004701350 6.987578e-02 2.245486e-01 3 37083636 37083644 9 - 1.988 1.919 -0.231
ENSG00000093167 E022 198.5762000 0.0003759458 9.857114e-02 2.793153e-01 3 37083645 37083806 162 - 2.324 2.281 -0.143
ENSG00000093167 E023 102.5937670 0.0008222736 1.469046e-02 7.693491e-02 3 37091467 37091538 72 - 2.060 1.970 -0.302
ENSG00000093167 E024 175.3993070 0.0004977677 2.416976e-02 1.096046e-01 3 37094792 37094908 117 - 2.279 2.216 -0.210
ENSG00000093167 E025 102.3102221 0.0004259619 1.266897e-02 6.912174e-02 3 37096616 37096660 45 - 2.059 1.971 -0.294
ENSG00000093167 E026 0.7914337 0.2652141824 7.773909e-01   3 37102924 37103013 90 - 0.287 0.221 -0.496
ENSG00000093167 E027 1.7816735 0.2509118971 6.164723e-01 7.813708e-01 3 37105455 37105523 69 - 0.513 0.360 -0.806
ENSG00000093167 E028 1.1176617 0.0153787590 5.689848e-02   3 37108073 37108129 57 - 0.462 0.123 -2.532
ENSG00000093167 E029 1.5699561 0.0126142572 5.518226e-04 6.147183e-03 3 37108637 37108684 48 - 0.620 0.000 -14.532
ENSG00000093167 E030 0.0000000       3 37109527 37109571 45 -      
ENSG00000093167 E031 1.2485298 0.0138197758 1.707357e-01   3 37109653 37109703 51 - 0.462 0.219 -1.534
ENSG00000093167 E032 1.3251976 0.0200036553 5.235562e-01   3 37110991 37111065 75 - 0.413 0.298 -0.685
ENSG00000093167 E033 0.3150090 0.0298127112 9.787807e-01   3 37111826 37111915 90 - 0.119 0.123 0.055
ENSG00000093167 E034 1.0829097 0.0737724915 2.610639e-01   3 37112915 37112980 66 - 0.213 0.421 1.371
ENSG00000093167 E035 0.1614157 0.0332705696 5.142243e-01   3 37115054 37115095 42 - 0.120 0.000 -11.211
ENSG00000093167 E036 0.7687085 0.0179262352 6.890145e-01   3 37121464 37121491 28 - 0.290 0.219 -0.534
ENSG00000093167 E037 6.8647244 0.0878335798 8.591057e-01 9.298752e-01 3 37121492 37121536 45 - 0.897 0.910 0.051
ENSG00000093167 E038 5.8818048 0.0303982237 2.578929e-01 4.966394e-01 3 37121635 37121665 31 - 0.759 0.914 0.605
ENSG00000093167 E039 5.5831267 0.0194861114 5.372076e-01 7.271275e-01 3 37121666 37121691 26 - 0.782 0.860 0.307
ENSG00000093167 E040 0.3206185 0.0274424043 2.157317e-01   3 37127630 37127680 51 - 0.213 0.000 -12.211
ENSG00000093167 E041 130.6155744 0.0003447321 5.343514e-01 7.251691e-01 3 37129063 37129149 87 - 2.132 2.113 -0.066
ENSG00000093167 E042 7.2567879 0.0050695421 4.836954e-07 1.503893e-05 3 37146329 37146425 97 - 1.136 0.472 -2.688
ENSG00000093167 E043 5.5279552 0.0047857588 3.252069e-06 7.952139e-05 3 37146426 37146453 28 - 1.034 0.364 -2.904
ENSG00000093167 E044 15.1255189 0.0066027354 5.991968e-09 2.941954e-07 3 37146454 37146627 174 - 1.410 0.818 -2.148
ENSG00000093167 E045 99.8012264 0.0004134405 2.673099e-02 1.174711e-01 3 37148894 37148926 33 - 2.045 1.966 -0.264
ENSG00000093167 E046 147.7086335 0.0002978428 1.389406e-03 1.282354e-02 3 37148927 37149038 112 - 2.218 2.124 -0.314
ENSG00000093167 E047 5.7481469 0.0052799763 3.036733e-01 5.442475e-01 3 37154614 37154656 43 - 0.902 0.772 -0.504
ENSG00000093167 E048 1.9577589 0.0129877161 1.257882e-02 6.875552e-02 3 37154657 37154724 68 - 0.651 0.219 -2.408
ENSG00000093167 E049 36.3890112 0.0031492228 2.014711e-14 2.827638e-12 3 37170333 37171066 734 - 1.758 1.241 -1.778
ENSG00000093167 E050 3.7438085 0.0081969917 2.208818e-04 2.903089e-03 3 37172770 37172790 21 - 0.883 0.298 -2.754
ENSG00000093167 E051 34.9669259 0.0013304403 1.791451e-05 3.480661e-04 3 37172791 37173026 236 - 1.410 1.671 0.894
ENSG00000093167 E052 18.1338001 0.0067183673 3.690701e-10 2.324799e-08 3 37173027 37173194 168 - 0.885 1.485 2.147
ENSG00000093167 E053 1.4217120 0.0128044846 1.693281e-02 8.520239e-02 3 37174119 37174538 420 - 0.548 0.123 -2.947
ENSG00000093167 E054 121.6933878 0.0003761369 5.388997e-02 1.888401e-01 3 37174539 37174605 67 - 2.062 2.124 0.206
ENSG00000093167 E055 0.4820342 0.0213193821 9.204917e-02   3 37174717 37175162 446 - 0.290 0.000 -12.796
ENSG00000093167 E056 0.1723744 0.0437690863 4.630435e-01   3 37175163 37175215 53 - 0.000 0.123 11.281
ENSG00000093167 E057 16.3516126 0.0762576427 9.492071e-01 9.767040e-01 3 37175818 37176059 242 - 1.225 1.255 0.105
ENSG00000093167 E058 106.8057373 0.0022941400 9.835883e-12 8.444687e-10 3 37176060 37176360 301 - 1.875 2.154 0.933
ENSG00000093167 E059 0.7119354 1.0631848760 3.850451e-01   3 37176369 37176532 164 - 0.372 0.000 -13.307
ENSG00000093167 E060 0.0000000       3 37183542 37183689 148 -