ENSG00000092853

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000251195 ENSG00000092853 HEK293_OSMI2_6hA HEK293_TMG_6hB CLSPN protein_coding protein_coding 15.02322 9.084515 22.56075 0.3425492 0.5921327 1.311386 2.5535864 2.3293953 2.866268 0.31395799 0.6350136 0.2980624 0.19851250 0.25770000 0.12630000 -0.13140000 0.1890369241 0.0002206294 FALSE TRUE
ENST00000318121 ENSG00000092853 HEK293_OSMI2_6hA HEK293_TMG_6hB CLSPN protein_coding protein_coding 15.02322 9.084515 22.56075 0.3425492 0.5921327 1.311386 3.9032851 2.9035272 4.816779 0.40696539 0.2664789 0.7282940 0.29997917 0.31710000 0.21316667 -0.10393333 0.2825798518 0.0002206294 FALSE TRUE
ENST00000373220 ENSG00000092853 HEK293_OSMI2_6hA HEK293_TMG_6hB CLSPN protein_coding protein_coding 15.02322 9.084515 22.56075 0.3425492 0.5921327 1.311386 0.8364386 0.1750067 1.956539 0.02491903 0.1986389 3.4100091 0.04571667 0.01930000 0.08656667 0.06726667 0.0002206294 0.0002206294 FALSE TRUE
ENST00000520551 ENSG00000092853 HEK293_OSMI2_6hA HEK293_TMG_6hB CLSPN protein_coding protein_coding 15.02322 9.084515 22.56075 0.3425492 0.5921327 1.311386 1.5077602 0.1298444 3.685064 0.12984440 0.5716805 4.7237049 0.07659583 0.01406667 0.16483333 0.15076667 0.0755770673 0.0002206294 FALSE TRUE
MSTRG.831.2 ENSG00000092853 HEK293_OSMI2_6hA HEK293_TMG_6hB CLSPN protein_coding   15.02322 9.084515 22.56075 0.3425492 0.5921327 1.311386 1.5959326 1.6593978 2.187288 0.21775821 0.3996198 0.3963960 0.11003750 0.18216667 0.09636667 -0.08580000 0.1927304798 0.0002206294 FALSE TRUE
MSTRG.831.4 ENSG00000092853 HEK293_OSMI2_6hA HEK293_TMG_6hB CLSPN protein_coding   15.02322 9.084515 22.56075 0.3425492 0.5921327 1.311386 2.6916788 0.9928782 4.506592 0.02579837 0.4309752 2.1710883 0.14452083 0.10980000 0.19913333 0.08933333 0.0531013915 0.0002206294 TRUE TRUE
MSTRG.831.7 ENSG00000092853 HEK293_OSMI2_6hA HEK293_TMG_6hB CLSPN protein_coding   15.02322 9.084515 22.56075 0.3425492 0.5921327 1.311386 0.9633310 0.4825780 2.043292 0.29525926 1.0751900 2.0595147 0.05364167 0.05576667 0.09130000 0.03553333 0.9677664893 0.0002206294 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000092853 E001 31.576522 0.4338701878 5.529140e-02 1.920016e-01 1 35720218 35720470 253 - 1.237 1.750 1.763
ENSG00000092853 E002 7.056256 0.0047051795 1.516841e-06 4.086856e-05 1 35720471 35720671 201 - 0.562 1.172 2.391
ENSG00000092853 E003 3.586575 0.1058516882 7.192179e-02 2.286375e-01 1 35720672 35720683 12 - 0.463 0.835 1.615
ENSG00000092853 E004 6.682620 0.0501586658 8.060733e-04 8.331191e-03 1 35720684 35720737 54 - 0.588 1.126 2.106
ENSG00000092853 E005 71.810816 0.7500352749 1.363625e-01 3.419441e-01 1 35720738 35720977 240 - 1.604 2.088 1.633
ENSG00000092853 E006 13.872138 0.3168397175 1.819677e-01 4.065494e-01 1 35720978 35720980 3 - 1.027 1.326 1.066
ENSG00000092853 E007 2.998054 0.0947283251 2.898267e-05 5.237204e-04 1 35723620 35723685 66 - 0.093 0.927 4.956
ENSG00000092853 E008 379.841146 0.0064297242 2.173392e-02 1.017006e-01 1 35732112 35736246 4135 - 2.511 2.642 0.436
ENSG00000092853 E009 37.721943 0.0011219214 3.623478e-01 5.976070e-01 1 35736247 35736280 34 - 1.577 1.552 -0.087
ENSG00000092853 E010 69.963305 0.0050220544 9.438703e-01 9.743037e-01 1 35736281 35736404 124 - 1.821 1.851 0.101
ENSG00000092853 E011 64.170482 0.0052723947 1.612511e-01 3.786446e-01 1 35736405 35736484 80 - 1.811 1.765 -0.155
ENSG00000092853 E012 81.171109 0.0045529389 7.906157e-01 8.908696e-01 1 35736485 35736606 122 - 1.889 1.908 0.063
ENSG00000092853 E013 138.591935 0.0048371302 8.047404e-03 4.952291e-02 1 35736914 35737075 162 - 2.072 2.219 0.491
ENSG00000092853 E014 96.050242 0.0004521995 5.884619e-03 3.917305e-02 1 35737339 35737421 83 - 1.919 2.050 0.440
ENSG00000092853 E015 2.111470 0.0108947840 8.561385e-02 2.556990e-01 1 35737698 35737991 294 - 0.562 0.271 -1.612
ENSG00000092853 E016 131.232153 0.0004671873 5.154294e-03 3.542649e-02 1 35737992 35738097 106 - 2.060 2.179 0.401
ENSG00000092853 E017 132.795196 0.0004415758 3.600001e-04 4.336831e-03 1 35738455 35738582 128 - 2.052 2.195 0.479
ENSG00000092853 E018 136.310799 0.0183815501 2.766748e-02 1.202966e-01 1 35739136 35739257 122 - 2.050 2.224 0.584
ENSG00000092853 E019 168.272244 0.3726113012 2.948334e-01 5.353537e-01 1 35739365 35739529 165 - 2.139 2.316 0.591
ENSG00000092853 E020 119.328910 1.3175982959 5.076464e-01 7.061419e-01 1 35743141 35743241 101 - 1.998 2.159 0.541
ENSG00000092853 E021 95.639795 1.2147080787 4.408205e-01 6.593341e-01 1 35743455 35743530 76 - 1.879 2.092 0.714
ENSG00000092853 E022 104.187384 0.0151884431 1.954855e-01 4.239838e-01 1 35745451 35745562 112 - 1.965 2.073 0.362
ENSG00000092853 E023 151.382184 0.0003203622 2.501034e-01 4.880419e-01 1 35746766 35746964 199 - 2.169 2.164 -0.014
ENSG00000092853 E024 76.048393 0.0005389119 2.065874e-01 4.376281e-01 1 35746965 35746992 28 - 1.878 1.855 -0.079
ENSG00000092853 E025 134.581825 0.0032485387 5.449016e-02 1.902132e-01 1 35747907 35748061 155 - 2.129 2.083 -0.154
ENSG00000092853 E026 131.586279 0.0015936336 1.617856e-01 3.794144e-01 1 35748405 35748604 200 - 2.111 2.092 -0.063
ENSG00000092853 E027 0.000000       1 35748605 35748774 170 -      
ENSG00000092853 E028 64.091695 0.0006899078 2.667995e-01 5.063556e-01 1 35749467 35749531 65 - 1.805 1.783 -0.072
ENSG00000092853 E029 47.338229 0.0009865621 5.651825e-01 7.468465e-01 1 35749633 35749652 20 - 1.671 1.671 -0.003
ENSG00000092853 E030 94.319217 0.0066077508 2.514316e-01 4.895032e-01 1 35749653 35749811 159 - 1.926 2.024 0.329
ENSG00000092853 E031 148.140486 0.0063007826 1.490850e-01 3.609338e-01 1 35751250 35751506 257 - 2.168 2.136 -0.107
ENSG00000092853 E032 124.041534 0.0037776376 3.939780e-03 2.880674e-02 1 35753745 35753936 192 - 2.111 2.018 -0.310
ENSG00000092853 E033 266.215330 0.0164911936 1.096990e-03 1.065207e-02 1 35760342 35760916 575 - 2.464 2.293 -0.570
ENSG00000092853 E034 74.768616 0.0079347956 1.156696e-01 3.086152e-01 1 35761096 35761204 109 - 1.883 1.824 -0.199
ENSG00000092853 E035 66.987468 0.0040510096 8.014049e-05 1.243235e-03 1 35761998 35762070 73 - 1.876 1.690 -0.627
ENSG00000092853 E036 84.106822 0.0047003647 7.570781e-05 1.184861e-03 1 35762404 35762481 78 - 1.968 1.793 -0.589
ENSG00000092853 E037 113.936748 0.0027564392 2.166676e-06 5.599625e-05 1 35763160 35763321 162 - 2.097 1.926 -0.576
ENSG00000092853 E038 208.291433 0.0038186622 9.552187e-08 3.562884e-06 1 35764266 35764714 449 - 2.360 2.187 -0.576
ENSG00000092853 E039 88.381093 0.0081213984 2.256505e-05 4.238013e-04 1 35765218 35765326 109 - 1.999 1.781 -0.735
ENSG00000092853 E040 61.169036 0.0060017385 1.197737e-04 1.735771e-03 1 35769847 35769998 152 - 1.838 1.635 -0.687