ENSG00000092203

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000448790 ENSG00000092203 HEK293_OSMI2_6hA HEK293_TMG_6hB TOX4 protein_coding protein_coding 57.65482 70.12023 49.43062 9.640013 2.932687 -0.5043396 18.172549 19.118863 15.551280 3.661615 0.6027816 -0.2977904 0.31407083 0.26916667 0.31546667 0.04630000 6.077156e-01 5.004619e-35 FALSE TRUE
ENST00000455138 ENSG00000092203 HEK293_OSMI2_6hA HEK293_TMG_6hB TOX4 protein_coding nonsense_mediated_decay 57.65482 70.12023 49.43062 9.640013 2.932687 -0.5043396 4.035270 10.038934 0.000000 1.908098 0.0000000 -9.9728268 0.06618750 0.14160000 0.00000000 -0.14160000 5.004619e-35 5.004619e-35 FALSE FALSE
ENST00000457430 ENSG00000092203 HEK293_OSMI2_6hA HEK293_TMG_6hB TOX4 protein_coding protein_coding 57.65482 70.12023 49.43062 9.640013 2.932687 -0.5043396 4.510875 1.669271 8.828062 1.669271 0.4684610 2.3958947 0.08469167 0.02266667 0.17953333 0.15686667 1.184205e-01 5.004619e-35 FALSE FALSE
ENST00000463119 ENSG00000092203 HEK293_OSMI2_6hA HEK293_TMG_6hB TOX4 protein_coding retained_intron 57.65482 70.12023 49.43062 9.640013 2.932687 -0.5043396 7.999198 12.257399 3.596387 1.197818 0.9208577 -1.7662031 0.13303333 0.17696667 0.07186667 -0.10510000 1.603101e-02 5.004619e-35 FALSE FALSE
ENST00000473176 ENSG00000092203 HEK293_OSMI2_6hA HEK293_TMG_6hB TOX4 protein_coding retained_intron 57.65482 70.12023 49.43062 9.640013 2.932687 -0.5043396 19.207033 23.139792 18.734770 3.281069 1.3226454 -0.3045111 0.33680833 0.32996667 0.37860000 0.04863333 4.122278e-01 5.004619e-35 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000092203 E001 0.3032425 0.0274424043 3.658409e-01   14 21476597 21476747 151 + 0.000 0.177 10.149
ENSG00000092203 E002 1.2614459 0.4238320187 3.308511e-01   14 21476755 21476867 113 + 0.148 0.457 2.196
ENSG00000092203 E003 1.4346281 0.2699914757 8.498584e-01 0.9248966929 14 21476868 21476873 6 + 0.346 0.427 0.454
ENSG00000092203 E004 1.5654963 0.3289203097 8.112632e-01 0.9030069097 14 21476874 21476896 23 + 0.346 0.460 0.629
ENSG00000092203 E005 2.2734672 0.0089031752 4.602561e-01 0.6732886446 14 21477122 21477181 60 + 0.423 0.547 0.614
ENSG00000092203 E006 2.7546935 0.0081071790 4.606112e-01 0.6735989445 14 21477182 21477194 13 + 0.486 0.605 0.555
ENSG00000092203 E007 3.0753120 0.0078269541 9.104763e-01 0.9573584587 14 21477195 21477202 8 + 0.590 0.605 0.069
ENSG00000092203 E008 8.0859699 0.0037339827 2.470290e-03 0.0201378677 14 21477203 21477217 15 + 1.126 0.782 -1.291
ENSG00000092203 E009 9.4965355 0.0032920743 7.793649e-05 0.0012139236 14 21477218 21477223 6 + 1.222 0.800 -1.562
ENSG00000092203 E010 22.7188053 0.0041271870 5.152979e-02 0.1833656649 14 21477224 21477232 9 + 1.443 1.290 -0.532
ENSG00000092203 E011 38.3621406 0.0010109645 1.418894e-03 0.0130347751 14 21477233 21477237 5 + 1.685 1.499 -0.633
ENSG00000092203 E012 93.7111322 0.0006366531 5.686744e-02 0.1957042164 14 21477238 21477263 26 + 2.003 1.928 -0.253
ENSG00000092203 E013 136.3217163 0.0004071914 1.845095e-01 0.4098282129 14 21477264 21477278 15 + 2.147 2.102 -0.149
ENSG00000092203 E014 148.6537449 0.0003966004 5.339806e-01 0.7249007911 14 21477279 21477284 6 + 2.170 2.148 -0.073
ENSG00000092203 E015 2.7443845 0.0092452340 3.422080e-03 0.0258909353 14 21477285 21477495 211 + 0.150 0.681 3.203
ENSG00000092203 E016 226.8416638 0.0007877074 5.253038e-01 0.7186539628 14 21477496 21477564 69 + 2.350 2.331 -0.063
ENSG00000092203 E017 0.5481031 0.2275398099 9.140499e-01   14 21477565 21477592 28 + 0.149 0.182 0.347
ENSG00000092203 E018 0.1614157 0.0324822219 3.062706e-01   14 21482552 21482611 60 + 0.150 0.000 -12.496
ENSG00000092203 E019 353.5983686 0.0002090030 2.270482e-01 0.4618192418 14 21487451 21487602 152 + 2.546 2.520 -0.086
ENSG00000092203 E020 212.4067668 0.0002675745 5.654742e-01 0.7470324899 14 21487603 21487646 44 + 2.321 2.304 -0.056
ENSG00000092203 E021 231.6783166 0.0002560991 9.270031e-01 0.9655694341 14 21487647 21487693 47 + 2.353 2.348 -0.015
ENSG00000092203 E022 9.3150650 0.0046918313 5.158373e-01 0.7121630912 14 21487694 21487860 167 + 1.053 0.981 -0.266
ENSG00000092203 E023 5.7078980 0.2279873489 3.123471e-01 0.5526481891 14 21487861 21488557 697 + 0.929 0.726 -0.792
ENSG00000092203 E024 4.1185482 0.0603400420 5.728875e-01 0.7522626742 14 21488558 21488589 32 + 0.632 0.728 0.403
ENSG00000092203 E025 544.0797539 0.0001340042 5.468561e-02 0.1906201146 14 21488590 21488850 261 + 2.739 2.707 -0.107
ENSG00000092203 E026 499.3889686 0.0001625681 1.665738e-01 0.3859795931 14 21489173 21489403 231 + 2.696 2.671 -0.083
ENSG00000092203 E027 2.8327167 0.0087977594 4.563217e-01 0.6705308827 14 21492097 21492295 199 + 0.486 0.606 0.559
ENSG00000092203 E028 257.3858423 0.0008318743 1.341906e-01 0.3384066610 14 21492296 21492376 81 + 2.372 2.410 0.126
ENSG00000092203 E029 308.6538160 0.0002133073 2.354176e-02 0.1076768180 14 21492508 21492613 106 + 2.442 2.488 0.153
ENSG00000092203 E030 167.4822434 0.0003909577 2.875145e-01 0.5282603913 14 21492614 21492615 2 + 2.189 2.218 0.097
ENSG00000092203 E031 899.5023648 0.0001907297 9.609585e-06 0.0002025479 14 21492616 21493257 642 + 2.902 2.956 0.179
ENSG00000092203 E032 470.8818115 0.0001891967 3.034617e-03 0.0236213858 14 21495229 21495392 164 + 2.623 2.672 0.163
ENSG00000092203 E033 24.4635406 0.0992392456 9.620332e-03 0.0564794584 14 21495393 21496227 835 + 1.601 1.186 -1.438
ENSG00000092203 E034 768.1872199 0.0010422797 2.473652e-01 0.4851380232 14 21496546 21499175 2630 + 2.882 2.863 -0.063