ENSG00000092201

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000216297 ENSG00000092201 HEK293_OSMI2_6hA HEK293_TMG_6hB SUPT16H protein_coding protein_coding 104.4277 61.37819 140.2539 8.782481 5.761506 1.192111 83.95729 41.31319 127.0659 5.885291 5.7925917 1.620666 0.7485333 0.6732 0.90563333 0.2324333 2.443812e-18 8.174438e-23 FALSE TRUE
ENST00000557394 ENSG00000092201 HEK293_OSMI2_6hA HEK293_TMG_6hB SUPT16H protein_coding retained_intron 104.4277 61.37819 140.2539 8.782481 5.761506 1.192111 18.55376 17.59064 10.8344 2.182239 0.3444072 -0.698678 0.2314208 0.2887 0.07753333 -0.2111667 8.174438e-23 8.174438e-23 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000092201 E001 6.342047 5.025700e-03 4.514913e-02 1.679979e-01 14 21351476 21351478 3 - 0.740 0.989 0.963
ENSG00000092201 E002 119.854552 4.370197e-04 9.555270e-15 1.406157e-12 14 21351479 21351546 68 - 1.951 2.210 0.868
ENSG00000092201 E003 3437.419052 5.426226e-05 1.356934e-131 1.152193e-126 14 21351547 21352818 1272 - 3.448 3.604 0.519
ENSG00000092201 E004 815.232258 8.793524e-05 2.077628e-07 7.132180e-06 14 21353488 21353559 72 - 2.855 2.922 0.223
ENSG00000092201 E005 502.497346 1.304005e-04 1.093216e-01 2.979893e-01 14 21353560 21353565 6 - 2.660 2.685 0.082
ENSG00000092201 E006 1175.543201 1.630241e-04 1.191058e-01 3.143996e-01 14 21353703 21353832 130 - 3.031 3.047 0.054
ENSG00000092201 E007 1232.187690 8.650708e-04 7.174743e-01 8.465832e-01 14 21354411 21354540 130 - 3.055 3.060 0.017
ENSG00000092201 E008 2.214175 9.540324e-03 1.336190e-01 3.374815e-01 14 21354541 21354943 403 - 0.398 0.644 1.184
ENSG00000092201 E009 1194.322618 5.476222e-04 3.768188e-02 1.487956e-01 14 21357197 21357366 170 - 3.033 3.064 0.101
ENSG00000092201 E010 606.462328 1.907609e-04 1.214287e-04 1.754863e-03 14 21357927 21358002 76 - 2.729 2.788 0.198
ENSG00000092201 E011 45.708934 1.542558e-01 6.261466e-01 7.880394e-01 14 21358003 21358314 312 - 1.645 1.618 -0.091
ENSG00000092201 E012 872.788776 7.974225e-04 2.888366e-03 2.273937e-02 14 21358315 21358427 113 - 2.889 2.942 0.175
ENSG00000092201 E013 902.153382 1.509880e-04 8.472889e-02 2.542031e-01 14 21359484 21359609 126 - 2.914 2.934 0.067
ENSG00000092201 E014 790.208653 6.573208e-04 7.161907e-01 8.457326e-01 14 21360415 21360533 119 - 2.867 2.856 -0.035
ENSG00000092201 E015 749.149264 1.112952e-04 3.799724e-01 6.121564e-01 14 21360846 21360972 127 - 2.837 2.847 0.032
ENSG00000092201 E016 703.414874 8.855029e-05 7.273993e-02 2.302629e-01 14 21361078 21361213 136 - 2.823 2.793 -0.100
ENSG00000092201 E017 622.487722 1.032855e-04 4.236089e-01 6.463211e-01 14 21362197 21362324 128 - 2.765 2.749 -0.053
ENSG00000092201 E018 760.212078 1.390236e-04 3.380913e-01 5.763763e-01 14 21362794 21362947 154 - 2.853 2.836 -0.058
ENSG00000092201 E019 747.398308 9.632358e-05 2.005074e-05 3.828857e-04 14 21363034 21363149 116 - 2.860 2.794 -0.220
ENSG00000092201 E020 716.640291 1.170116e-04 1.176520e-07 4.292163e-06 14 21363233 21363328 96 - 2.847 2.763 -0.280
ENSG00000092201 E021 569.327268 1.205373e-03 2.132758e-02 1.004051e-01 14 21363438 21363503 66 - 2.741 2.684 -0.189
ENSG00000092201 E022 669.390011 8.090858e-04 1.682849e-02 8.483402e-02 14 21364827 21364939 113 - 2.809 2.757 -0.174
ENSG00000092201 E023 518.661433 1.128526e-04 3.531775e-04 4.270290e-03 14 21365070 21365143 74 - 2.701 2.635 -0.220
ENSG00000092201 E024 559.036582 1.284247e-04 1.383982e-05 2.777499e-04 14 21366439 21366529 91 - 2.738 2.660 -0.258
ENSG00000092201 E025 671.742200 4.905227e-04 1.489738e-03 1.354346e-02 14 21368269 21368441 173 - 2.813 2.753 -0.200
ENSG00000092201 E026 693.986331 2.293497e-03 1.150445e-02 6.440694e-02 14 21369204 21369348 145 - 2.831 2.758 -0.243
ENSG00000092201 E027 348.202157 7.100662e-04 1.630269e-02 8.290159e-02 14 21369349 21369355 7 - 2.530 2.468 -0.207
ENSG00000092201 E028 3.554176 2.884428e-02 8.968493e-02 2.632273e-01 14 21369436 21369749 314 - 0.705 0.391 -1.478
ENSG00000092201 E029 511.721824 1.309411e-03 1.053422e-03 1.031941e-02 14 21369750 21369819 70 - 2.702 2.618 -0.281
ENSG00000092201 E030 514.244127 1.131173e-03 6.665494e-03 4.302372e-02 14 21369820 21369896 77 - 2.699 2.631 -0.226
ENSG00000092201 E031 732.706842 1.017200e-04 1.827070e-19 4.956525e-17 14 21370336 21370488 153 - 2.871 2.729 -0.470
ENSG00000092201 E032 647.473619 5.470547e-04 4.030934e-22 1.514481e-19 14 21371874 21371970 97 - 2.829 2.636 -0.642
ENSG00000092201 E033 475.142377 1.242499e-04 2.515034e-31 2.259844e-28 14 21371971 21372044 74 - 2.704 2.474 -0.765
ENSG00000092201 E034 3.341148 1.082665e-01 4.249104e-01 6.472174e-01 14 21372075 21372468 394 - 0.649 0.473 -0.810
ENSG00000092201 E035 9.530957 3.547180e-03 7.649477e-02 2.377353e-01 14 21372469 21372717 249 - 1.052 0.834 -0.818
ENSG00000092201 E036 576.645441 1.616238e-03 2.678365e-10 1.734737e-08 14 21373338 21373430 93 - 2.774 2.609 -0.551
ENSG00000092201 E037 36.470536 7.619856e-03 6.799329e-16 1.172266e-13 14 21382975 21383769 795 - 1.268 1.840 1.958
ENSG00000092201 E038 525.479164 2.764364e-03 2.629099e-04 3.353502e-03 14 21383862 21384714 853 - 2.721 2.607 -0.381