ENSG00000092140

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000206595 ENSG00000092140 HEK293_OSMI2_6hA HEK293_TMG_6hB G2E3 protein_coding protein_coding 13.11442 1.924979 28.71058 0.1851633 1.612453 3.891695 4.76119579 0.94769229 9.4356801 0.22336454 0.18753363 3.30202059 0.49225000 0.48596667 0.330400000 -0.15556667 0.548667967 0.004186202 FALSE TRUE
ENST00000438909 ENSG00000092140 HEK293_OSMI2_6hA HEK293_TMG_6hB G2E3 protein_coding protein_coding 13.11442 1.924979 28.71058 0.1851633 1.612453 3.891695 0.61629796 0.03483533 2.1297128 0.03483533 0.20613061 5.57663731 0.05265833 0.01963333 0.074866667 0.05523333 0.203986076 0.004186202 FALSE TRUE
ENST00000548934 ENSG00000092140 HEK293_OSMI2_6hA HEK293_TMG_6hB G2E3 protein_coding nonsense_mediated_decay 13.11442 1.924979 28.71058 0.1851633 1.612453 3.891695 0.92613944 0.00000000 2.9130369 0.00000000 0.94834290 8.19132425 0.04132083 0.00000000 0.098366667 0.09836667 0.004186202 0.004186202 TRUE FALSE
ENST00000549553 ENSG00000092140 HEK293_OSMI2_6hA HEK293_TMG_6hB G2E3 protein_coding processed_transcript 13.11442 1.924979 28.71058 0.1851633 1.612453 3.891695 0.48351718 0.10704748 0.7004547 0.05456516 0.05990222 2.60164878 0.06170833 0.05270000 0.024333333 -0.02836667 0.333231590 0.004186202 FALSE FALSE
ENST00000552515 ENSG00000092140 HEK293_OSMI2_6hA HEK293_TMG_6hB G2E3 protein_coding protein_coding 13.11442 1.924979 28.71058 0.1851633 1.612453 3.891695 0.03753797 0.14633770 0.1539660 0.14633770 0.15396603 0.06873121 0.01095833 0.08243333 0.005233333 -0.07720000 0.791231793 0.004186202 FALSE FALSE
MSTRG.9309.1 ENSG00000092140 HEK293_OSMI2_6hA HEK293_TMG_6hB G2E3 protein_coding   13.11442 1.924979 28.71058 0.1851633 1.612453 3.891695 5.26660393 0.43342220 11.4206067 0.22366078 0.50499866 4.68807716 0.23892083 0.21670000 0.399633333 0.18293333 0.716989618 0.004186202 FALSE TRUE
MSTRG.9309.2 ENSG00000092140 HEK293_OSMI2_6hA HEK293_TMG_6hB G2E3 protein_coding   13.11442 1.924979 28.71058 0.1851633 1.612453 3.891695 0.28302130 0.13395160 0.6923041 0.13395160 0.36218373 2.28651205 0.02045417 0.07546667 0.024233333 -0.05123333 0.992669652 0.004186202 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000092140 E001 0.9523018 0.0159968394 5.189901e-01   14 30559146 30559157 12 + 0.176 0.310 1.066
ENSG00000092140 E002 0.9523018 0.0159968394 5.189901e-01   14 30559158 30559159 2 + 0.176 0.310 1.066
ENSG00000092140 E003 43.4256023 0.0008850592 9.515594e-01 0.977719750 14 30559160 30559221 62 + 1.410 1.416 0.021
ENSG00000092140 E004 62.8775949 0.0005982179 9.479076e-01 0.976230529 14 30559222 30559272 51 + 1.567 1.563 -0.014
ENSG00000092140 E005 1.0290398 0.0164470322 1.320920e-01   14 30559310 30560842 1533 + 0.175 0.489 2.067
ENSG00000092140 E006 0.0000000       14 30574535 30574590 56 +      
ENSG00000092140 E007 0.0000000       14 30577756 30577760 5 +      
ENSG00000092140 E008 0.0000000       14 30577761 30577846 86 +      
ENSG00000092140 E009 1.2387389 0.2208936222 6.479345e-01   14 30580864 30580947 84 + 0.225 0.314 0.642
ENSG00000092140 E010 66.0742828 0.0005575619 7.089787e-01 0.841134903 14 30581076 30581116 41 + 1.589 1.563 -0.092
ENSG00000092140 E011 98.8934368 0.0004570850 8.871709e-01 0.945197422 14 30586718 30586815 98 + 1.759 1.751 -0.026
ENSG00000092140 E012 94.0803992 0.0004136938 5.792451e-02 0.198135540 14 30589383 30589484 102 + 1.746 1.621 -0.427
ENSG00000092140 E013 1.8318099 0.0163541298 1.000000e+00 1.000000000 14 30590532 30590963 432 + 0.301 0.311 0.067
ENSG00000092140 E014 87.8354696 0.0006440514 1.108379e-01 0.300348236 14 30592323 30592447 125 + 1.718 1.610 -0.369
ENSG00000092140 E015 92.8716710 0.0020850204 7.034957e-03 0.044795559 14 30593474 30593591 118 + 1.747 1.550 -0.672
ENSG00000092140 E016 65.5809711 0.0070840175 7.844730e-03 0.048603267 14 30593592 30593639 48 + 1.601 1.341 -0.895
ENSG00000092140 E017 90.3417117 0.0033223001 2.741341e-02 0.119538510 14 30597420 30597526 107 + 1.730 1.563 -0.569
ENSG00000092140 E018 6.7111855 0.0045939722 1.350511e-03 0.012536783 14 30598100 30598482 383 + 0.622 1.096 1.848
ENSG00000092140 E019 86.0225948 0.0025210763 7.730656e-01 0.880528969 14 30598483 30598557 75 + 1.700 1.681 -0.066
ENSG00000092140 E020 74.3371268 0.0005740867 9.107370e-01 0.957494498 14 30598558 30598599 42 + 1.638 1.631 -0.023
ENSG00000092140 E021 104.3760724 0.0004164854 4.735581e-01 0.682488528 14 30601770 30601894 125 + 1.777 1.818 0.140
ENSG00000092140 E022 93.4801103 0.0005688376 9.076414e-01 0.955962200 14 30601999 30602131 133 + 1.735 1.743 0.028
ENSG00000092140 E023 0.5008152 0.0367001522 1.000000e+00   14 30602631 30602746 116 + 0.114 0.000 -8.843
ENSG00000092140 E024 1.3575981 0.2778809055 6.948887e-01   14 30602747 30602889 143 + 0.260 0.000 -9.538
ENSG00000092140 E025 150.9521167 0.0003237496 3.188319e-01 0.558587401 14 30605505 30605812 308 + 1.943 1.894 -0.165
ENSG00000092140 E026 127.6878256 0.0003771195 9.167350e-01 0.960512157 14 30607888 30608069 182 + 1.868 1.864 -0.015
ENSG00000092140 E027 3.4504590 0.0075840902 4.047494e-02 0.155958878 14 30611302 30612206 905 + 0.414 0.795 1.714
ENSG00000092140 E028 130.9123231 0.0005154803 7.959386e-01 0.893977194 14 30612207 30612379 173 + 1.882 1.870 -0.042
ENSG00000092140 E029 128.4081799 0.0050661005 9.077776e-02 0.265169372 14 30615349 30615539 191 + 1.863 1.961 0.329
ENSG00000092140 E030 438.4026307 0.0002855879 9.736528e-05 0.001462098 14 30616278 30620064 3787 + 2.389 2.487 0.328