ENSG00000091844

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000206262 ENSG00000091844 HEK293_OSMI2_6hA HEK293_TMG_6hB RGS17 protein_coding protein_coding 2.713581 2.139658 3.000473 0.4569756 0.6216179 0.485883 0.7103582 0.2234394 1.247974 0.04122272 0.08240825 2.4299816 0.2588875 0.1055667 0.4407667 0.3352 0.0005478944 0.0005366928 FALSE TRUE
MSTRG.29186.3 ENSG00000091844 HEK293_OSMI2_6hA HEK293_TMG_6hB RGS17 protein_coding   2.713581 2.139658 3.000473 0.4569756 0.6216179 0.485883 1.9915084 1.9162186 1.752499 0.41694550 0.54035796 -0.1281488 0.7326125 0.8944333 0.5592333 -0.3352 0.0005366928 0.0005366928   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000091844 E001 118.574144 0.0005443109 4.012833e-14 5.378621e-12 6 153004459 153011762 7304 - 2.056 1.858 -0.666
ENSG00000091844 E002 21.836101 0.0023250648 2.718699e-01 5.117415e-01 6 153024262 153024496 235 - 1.276 1.362 0.301
ENSG00000091844 E003 2.533986 0.0095775198 7.863675e-03 4.869577e-02 6 153025114 153025142 29 - 0.360 0.784 1.980
ENSG00000091844 E004 14.143172 0.0023369207 4.097918e-03 2.971603e-02 6 153026454 153026543 90 - 1.047 1.305 0.921
ENSG00000091844 E005 18.699986 0.0019951344 2.685975e-05 4.903679e-04 6 153043900 153044043 144 - 1.131 1.457 1.141
ENSG00000091844 E006 13.050942 0.0029528183 1.302447e-03 1.218317e-02 6 153131124 153131282 159 - 0.993 1.293 1.074