ENSG00000091527

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264993 ENSG00000091527 HEK293_OSMI2_6hA HEK293_TMG_6hB CDV3 protein_coding protein_coding 89.71821 59.7816 113.901 14.95373 5.299444 0.9298922 30.241417 19.596436 33.672957 4.481736 0.8420616 0.7806915 0.3261333 0.3342667 0.29633333 -0.03793333 0.709880824 0.001675419 FALSE TRUE
ENST00000420115 ENSG00000091527 HEK293_OSMI2_6hA HEK293_TMG_6hB CDV3 protein_coding protein_coding 89.71821 59.7816 113.901 14.95373 5.299444 0.9298922 14.139757 7.384263 25.724028 2.283620 1.1774169 1.7991991 0.1521833 0.1177000 0.22600000 0.10830000 0.001675419 0.001675419 FALSE FALSE
ENST00000515421 ENSG00000091527 HEK293_OSMI2_6hA HEK293_TMG_6hB CDV3 protein_coding protein_coding 89.71821 59.7816 113.901 14.95373 5.299444 0.9298922 8.789953 10.209555 4.802182 5.081857 1.2311748 -1.0865694 0.1204125 0.1700333 0.04323333 -0.12680000 0.200048898 0.001675419 FALSE FALSE
MSTRG.23727.5 ENSG00000091527 HEK293_OSMI2_6hA HEK293_TMG_6hB CDV3 protein_coding   89.71821 59.7816 113.901 14.95373 5.299444 0.9298922 11.622895 6.837092 14.513716 1.761354 2.0496425 1.0848473 0.1200833 0.1139000 0.12750000 0.01360000 0.914684700 0.001675419 FALSE TRUE
MSTRG.23727.8 ENSG00000091527 HEK293_OSMI2_6hA HEK293_TMG_6hB CDV3 protein_coding   89.71821 59.7816 113.901 14.95373 5.299444 0.9298922 20.999076 14.063432 27.277572 5.008289 3.8246476 0.9552699 0.2383417 0.2263667 0.23743333 0.01106667 0.970462543 0.001675419 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000091527 E001 47.1522211 0.0104000158 7.306252e-04 7.701382e-03 3 133573686 133573747 62 + 1.550 1.827 0.939
ENSG00000091527 E002 79.0808760 0.0064419723 1.439978e-08 6.521103e-07 3 133573748 133573970 223 + 1.730 2.081 1.181
ENSG00000091527 E003 31.4958448 0.0018535154 6.512905e-09 3.178279e-07 3 133573971 133573975 5 + 1.305 1.712 1.397
ENSG00000091527 E004 57.5573120 0.0012964365 2.362902e-06 6.033305e-05 3 133573976 133574044 69 + 1.636 1.902 0.899
ENSG00000091527 E005 69.9852840 0.0117042448 3.889536e-03 2.852780e-02 3 133574045 133574180 136 + 1.742 1.959 0.732
ENSG00000091527 E006 141.2582481 0.0018023569 7.563158e-01 8.704125e-01 3 133574181 133574284 104 + 2.132 2.157 0.083
ENSG00000091527 E007 0.5173834 0.0571307921 2.028743e-01   3 133574412 133574433 22 + 0.238 0.000 -10.948
ENSG00000091527 E008 0.8402147 0.1273679054 8.112848e-02   3 133574434 133574456 23 + 0.347 0.000 -11.693
ENSG00000091527 E009 1.1019510 0.1224578339 5.989346e-01   3 133574457 133574497 41 + 0.347 0.266 -0.538
ENSG00000091527 E010 1.8457215 0.1313812406 6.557332e-01 8.071627e-01 3 133574498 133574551 54 + 0.471 0.425 -0.238
ENSG00000091527 E011 2.1192243 0.0969178905 7.323971e-01 8.556594e-01 3 133574552 133574592 41 + 0.505 0.489 -0.076
ENSG00000091527 E012 0.9444795 0.0194517880 8.089236e-01   3 133574593 133574637 45 + 0.295 0.269 -0.180
ENSG00000091527 E013 0.7664957 0.0180787293 9.336689e-01   3 133574638 133574647 10 + 0.237 0.269 0.236
ENSG00000091527 E014 1.4265137 0.0125324685 3.129328e-01 5.532569e-01 3 133574648 133574742 95 + 0.431 0.269 -0.987
ENSG00000091527 E015 0.6953672 0.2628585444 1.686764e-01   3 133574743 133574756 14 + 0.300 0.000 -11.391
ENSG00000091527 E016 264.6680648 0.0020993253 6.946755e-01 8.320942e-01 3 133575039 133575115 77 + 2.403 2.423 0.067
ENSG00000091527 E017 203.3400881 0.0025416971 8.080876e-01 9.010865e-01 3 133584002 133584004 3 + 2.287 2.309 0.072
ENSG00000091527 E018 543.6722537 0.0003195177 4.343614e-01 6.545039e-01 3 133584005 133584150 146 + 2.714 2.738 0.080
ENSG00000091527 E019 290.9966581 0.0005013423 5.533769e-01 7.386144e-01 3 133586563 133586568 6 + 2.444 2.470 0.087
ENSG00000091527 E020 648.8873858 0.0006930806 3.474112e-01 5.848708e-01 3 133586569 133586722 154 + 2.792 2.812 0.065
ENSG00000091527 E021 116.6563480 0.0003733614 2.835135e-01 5.239564e-01 3 133587159 133587161 3 + 2.057 2.059 0.006
ENSG00000091527 E022 686.9996964 0.0001556693 7.705710e-31 6.642674e-28 3 133587162 133587895 734 + 2.868 2.737 -0.438
ENSG00000091527 E023 941.5859184 0.0002546282 1.413161e-11 1.186881e-09 3 133587896 133588352 457 + 2.978 2.927 -0.170
ENSG00000091527 E024 3687.7287276 0.0046499272 3.476177e-02 1.409886e-01 3 133588353 133590261 1909 + 3.521 3.599 0.259