ENSG00000091490

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264868 ENSG00000091490 HEK293_OSMI2_6hA HEK293_TMG_6hB SEL1L3 protein_coding protein_coding 4.467118 2.097106 4.13045 0.2521881 0.3934973 0.9745248 1.6525671 1.3741544 2.0884020 0.12229921 0.20458826 0.60028626 0.44250000 0.6653667 0.52340000 -0.14196667 7.128624e-01 1.961743e-05 FALSE TRUE
ENST00000399878 ENSG00000091490 HEK293_OSMI2_6hA HEK293_TMG_6hB SEL1L3 protein_coding protein_coding 4.467118 2.097106 4.13045 0.2521881 0.3934973 0.9745248 1.1497931 0.3582923 0.3681599 0.17800464 0.22531483 0.03814508 0.22347083 0.1566333 0.09246667 -0.06416667 8.103761e-01 1.961743e-05 FALSE TRUE
ENST00000510448 ENSG00000091490 HEK293_OSMI2_6hA HEK293_TMG_6hB SEL1L3 protein_coding protein_coding 4.467118 2.097106 4.13045 0.2521881 0.3934973 0.9745248 0.2100664 0.2535560 0.1317839 0.08766039 0.05828762 -0.89441557 0.05629167 0.1161667 0.03343333 -0.08273333 2.894276e-01 1.961743e-05 FALSE TRUE
ENST00000510880 ENSG00000091490 HEK293_OSMI2_6hA HEK293_TMG_6hB SEL1L3 protein_coding protein_coding 4.467118 2.097106 4.13045 0.2521881 0.3934973 0.9745248 0.4446549 0.0000000 0.4257686 0.00000000 0.42576859 5.44549030 0.06666250 0.0000000 0.08706667 0.08706667 9.417247e-01 1.961743e-05   FALSE
MSTRG.24709.5 ENSG00000091490 HEK293_OSMI2_6hA HEK293_TMG_6hB SEL1L3 protein_coding   4.467118 2.097106 4.13045 0.2521881 0.3934973 0.9745248 0.7483226 0.0000000 0.7615545 0.00000000 0.23881390 6.26969621 0.15112500 0.0000000 0.17733333 0.17733333 1.961743e-05 1.961743e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000091490 E001 0.1308682 0.030881672 0.32631586   4 25747433 25747433 1 - 0.000 0.146 9.421
ENSG00000091490 E002 33.4153136 0.001141799 0.08130104 0.2474290 4 25747434 25748063 630 - 1.480 1.586 0.362
ENSG00000091490 E003 19.0772130 0.002309829 0.78826128 0.8895150 4 25748064 25748265 202 - 1.307 1.287 -0.072
ENSG00000091490 E004 31.0296886 0.001569257 0.58725361 0.7617915 4 25748266 25748564 299 - 1.487 1.522 0.120
ENSG00000091490 E005 5.5610983 0.098534164 0.01970385 0.0949052 4 25755922 25756908 987 - 0.561 1.005 1.788
ENSG00000091490 E006 17.6103852 0.001946407 0.35459881 0.5913799 4 25757534 25757606 73 - 1.228 1.304 0.268
ENSG00000091490 E007 21.0067949 0.007664907 0.39887636 0.6273060 4 25757688 25757790 103 - 1.297 1.370 0.255
ENSG00000091490 E008 0.6356275 0.020884493 0.55026767   4 25757791 25757852 62 - 0.251 0.146 -0.970
ENSG00000091490 E009 21.6082594 0.001607269 0.23131989 0.4666489 4 25758941 25759068 128 - 1.308 1.397 0.311
ENSG00000091490 E010 0.4646582 0.023052318 0.35223292   4 25759069 25759977 909 - 0.101 0.255 1.611
ENSG00000091490 E011 15.4327291 0.002394450 0.72153773 0.8490829 4 25765326 25765435 110 - 1.186 1.219 0.118
ENSG00000091490 E012 10.2476263 0.003324831 0.99970576 1.0000000 4 25767525 25767583 59 - 1.038 1.040 0.008
ENSG00000091490 E013 12.3655297 0.003091578 0.14478609 0.3546365 4 25767584 25767609 26 - 1.058 1.198 0.501
ENSG00000091490 E014 20.0664525 0.004206703 0.95478237 0.9792886 4 25767740 25767830 91 - 1.318 1.313 -0.017
ENSG00000091490 E015 19.4505837 0.004986000 0.73540849 0.8575440 4 25776277 25776360 84 - 1.307 1.279 -0.098
ENSG00000091490 E016 0.7992560 0.193092745 0.43464928   4 25776361 25776719 359 - 0.310 0.146 -1.376
ENSG00000091490 E017 0.6592102 0.073191034 0.69095775   4 25777616 25777891 276 - 0.183 0.254 0.601
ENSG00000091490 E018 22.6405759 0.001609001 0.66235922 0.8113550 4 25779076 25779203 128 - 1.350 1.383 0.114
ENSG00000091490 E019 23.8426958 0.001610302 0.62169924 0.7849715 4 25782242 25782418 177 - 1.402 1.368 -0.118
ENSG00000091490 E020 16.3813812 0.001981634 0.27732543 0.5173534 4 25784228 25784290 63 - 1.267 1.175 -0.324
ENSG00000091490 E021 22.2093709 0.001694071 0.69327423 0.8312194 4 25788224 25788364 141 - 1.365 1.338 -0.095
ENSG00000091490 E022 20.4611413 0.001769407 0.95149475 0.9777197 4 25790455 25790574 120 - 1.324 1.321 -0.010
ENSG00000091490 E023 24.9141728 0.005502932 0.05821780 0.1987640 4 25802283 25802462 180 - 1.334 1.481 0.507
ENSG00000091490 E024 21.7121217 0.002284164 0.11466893 0.3069000 4 25804541 25804752 212 - 1.291 1.411 0.419
ENSG00000091490 E025 14.4132677 0.002579094 0.48688333 0.6918236 4 25818138 25818278 141 - 1.200 1.139 -0.218
ENSG00000091490 E026 16.0001495 0.008159820 0.10994750 0.2989372 4 25819808 25819940 133 - 1.266 1.116 -0.535
ENSG00000091490 E027 19.8444775 0.001875503 0.67426882 0.8190767 4 25821996 25822128 133 - 1.319 1.287 -0.110
ENSG00000091490 E028 15.5085253 0.002424909 0.56765065 0.7485238 4 25830098 25830156 59 - 1.235 1.186 -0.172
ENSG00000091490 E029 15.8830367 0.002229501 0.25832297 0.4971105 4 25832995 25833062 68 - 1.260 1.163 -0.344
ENSG00000091490 E030 12.3059140 0.003165076 0.18009943 0.4041522 4 25833063 25833110 48 - 1.171 1.040 -0.470
ENSG00000091490 E031 16.1722320 0.005413187 0.97540124 0.9895254 4 25833448 25833569 122 - 1.234 1.238 0.014
ENSG00000091490 E032 18.6460146 0.002528200 0.88327356 0.9429719 4 25835197 25835323 127 - 1.279 1.269 -0.034
ENSG00000091490 E033 15.6273373 0.002476851 0.08004603 0.2449396 4 25847294 25847342 49 - 1.267 1.113 -0.547
ENSG00000091490 E034 15.9440252 0.003730678 0.08288284 0.2505096 4 25847343 25847381 39 - 1.279 1.125 -0.545
ENSG00000091490 E035 18.9791882 0.004053022 0.07298570 0.2307975 4 25847382 25847460 79 - 1.345 1.197 -0.520
ENSG00000091490 E036 16.8616139 0.002402563 0.21474398 0.4472074 4 25847461 25847515 55 - 1.279 1.175 -0.367
ENSG00000091490 E037 23.1575539 0.001462147 0.39088101 0.6210526 4 25847516 25847726 211 - 1.398 1.337 -0.210
ENSG00000091490 E038 9.4167091 0.003402693 0.50259980 0.7025805 4 25847727 25847845 119 - 0.983 1.056 0.268
ENSG00000091490 E039 2.6302427 0.008136421 0.41034803 0.6363021 4 25847846 25847864 19 - 0.490 0.623 0.613
ENSG00000091490 E040 0.0000000       4 25860601 25860631 31 -      
ENSG00000091490 E041 1.9404850 0.010573524 0.19947641 0.4290638 4 25862675 25862988 314 - 0.362 0.579 1.100
ENSG00000091490 E042 0.0000000       4 25863434 25863455 22 -      
ENSG00000091490 E043 0.0000000       4 25863456 25863595 140 -      
ENSG00000091490 E044 0.0000000       4 25863607 25863620 14 -      
ENSG00000091490 E045 0.0000000       4 25863621 25863760 140 -