ENSG00000091409

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264107 ENSG00000091409 HEK293_OSMI2_6hA HEK293_TMG_6hB ITGA6 protein_coding protein_coding 4.341645 2.396879 8.068 0.5863297 0.2225452 1.746835 0.4708260 0.1731857 1.3512861 0.1081574 0.1433664 2.893591 0.1002125 0.1179000 0.16783333 0.04993333 0.726095881 0.004965866 FALSE TRUE
ENST00000409080 ENSG00000091409 HEK293_OSMI2_6hA HEK293_TMG_6hB ITGA6 protein_coding protein_coding 4.341645 2.396879 8.068 0.5863297 0.2225452 1.746835 2.2948024 0.5213572 5.5816743 0.3588504 0.4199299 3.395527 0.3921083 0.2333000 0.69343333 0.46013333 0.354701880 0.004965866 FALSE TRUE
ENST00000416789 ENSG00000091409 HEK293_OSMI2_6hA HEK293_TMG_6hB ITGA6 protein_coding protein_coding 4.341645 2.396879 8.068 0.5863297 0.2225452 1.746835 0.4982490 0.8221433 0.1216218 0.3379768 0.1216218 -2.660434 0.2345167 0.3058667 0.01500000 -0.29086667 0.028343544 0.004965866 FALSE TRUE
ENST00000470259 ENSG00000091409 HEK293_OSMI2_6hA HEK293_TMG_6hB ITGA6 protein_coding retained_intron 4.341645 2.396879 8.068 0.5863297 0.2225452 1.746835 0.1420282 0.0000000 0.5294052 0.0000000 0.1356525 5.753298 0.0253625 0.0000000 0.06486667 0.06486667 0.004965866 0.004965866   FALSE
ENST00000684293 ENSG00000091409 HEK293_OSMI2_6hA HEK293_TMG_6hB ITGA6 protein_coding protein_coding 4.341645 2.396879 8.068 0.5863297 0.2225452 1.746835 0.6593257 0.7479000 0.0000000 0.4895879 0.0000000 -6.243936 0.1819750 0.2493333 0.00000000 -0.24933333 0.129035848 0.004965866 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000091409 E001 0.1723744 0.157980005 1.420257e-01   2 172427354 172427417 64 + 0.000 0.200 10.625
ENSG00000091409 E002 0.1723744 0.157980005 1.420257e-01   2 172427418 172427470 53 + 0.000 0.200 12.725
ENSG00000091409 E003 1.1552083 0.063343210 1.282689e-02   2 172427586 172427667 82 + 0.132 0.595 3.046
ENSG00000091409 E004 2.4187473 0.022605651 8.885864e-04 9.002112e-03 2 172427668 172427788 121 + 0.276 0.835 2.715
ENSG00000091409 E005 12.3221131 0.501436042 3.155981e-01 5.555985e-01 2 172427789 172427970 182 + 1.012 1.196 0.664
ENSG00000091409 E006 16.7063211 0.602186102 3.985802e-01 6.271422e-01 2 172465539 172465663 125 + 1.148 1.281 0.470
ENSG00000091409 E007 19.0629592 0.017128495 4.111638e-01 6.369187e-01 2 172467481 172467560 80 + 1.263 1.175 -0.313
ENSG00000091409 E008 0.0000000       2 172468998 172469124 127 +      
ENSG00000091409 E009 40.1395681 0.001112305 1.296848e-01 3.313392e-01 2 172469125 172469380 256 + 1.570 1.480 -0.310
ENSG00000091409 E010 35.1915757 0.001170417 1.431151e-01 3.521457e-01 2 172470974 172471105 132 + 1.510 1.417 -0.323
ENSG00000091409 E011 0.0000000       2 172472774 172472890 117 +      
ENSG00000091409 E012 46.7138189 0.002915901 4.248876e-02 1.612089e-01 2 172474055 172474265 211 + 1.638 1.512 -0.432
ENSG00000091409 E013 38.8455122 0.058688104 2.189043e-01 4.521294e-01 2 172474929 172475122 194 + 1.571 1.388 -0.629
ENSG00000091409 E014 23.7117224 0.001767848 2.120184e-02 9.999058e-02 2 172475597 172475685 89 + 1.370 1.176 -0.683
ENSG00000091409 E015 24.8493310 0.001647974 1.245737e-02 6.827872e-02 2 172476395 172476513 119 + 1.387 1.176 -0.738
ENSG00000091409 E016 24.3778802 0.001792184 7.707169e-02 2.389307e-01 2 172479641 172479739 99 + 1.367 1.224 -0.501
ENSG00000091409 E017 19.7693963 0.012217389 4.611956e-01 6.739690e-01 2 172479990 172480051 62 + 1.263 1.193 -0.247
ENSG00000091409 E018 34.6691578 0.014149623 9.370860e-01 9.707466e-01 2 172484782 172484942 161 + 1.480 1.481 0.002
ENSG00000091409 E019 34.9815349 0.001055662 6.078118e-01 7.754158e-01 2 172485121 172485264 144 + 1.483 1.527 0.151
ENSG00000091409 E020 30.6451320 0.001397715 1.017440e-01 2.849212e-01 2 172487023 172487138 116 + 1.459 1.343 -0.404
ENSG00000091409 E021 33.4520032 0.001115940 4.498932e-01 6.656173e-01 2 172487264 172487453 190 + 1.481 1.436 -0.155
ENSG00000091409 E022 21.5856744 0.026900790 8.187531e-01 9.072960e-01 2 172487547 172487630 84 + 1.289 1.300 0.038
ENSG00000091409 E023 28.5053919 0.036774125 9.468146e-01 9.757283e-01 2 172487728 172487807 80 + 1.398 1.433 0.119
ENSG00000091409 E024 17.8716870 0.015809992 8.897801e-01 9.465782e-01 2 172487961 172487961 1 + 1.205 1.235 0.107
ENSG00000091409 E025 25.7625799 0.013597420 3.660841e-01 6.008282e-01 2 172487962 172488004 43 + 1.381 1.314 -0.234
ENSG00000091409 E026 23.5455239 0.001495914 7.706146e-01 8.790467e-01 2 172488005 172488038 34 + 1.332 1.319 -0.048
ENSG00000091409 E027 32.5342088 0.001332941 9.853317e-01 9.944376e-01 2 172488126 172488228 103 + 1.462 1.471 0.029
ENSG00000091409 E028 37.1474441 0.001126078 1.498997e-02 7.804179e-02 2 172489485 172489613 129 + 1.549 1.386 -0.561
ENSG00000091409 E029 22.3806421 0.001574713 1.880603e-01 4.144892e-01 2 172489614 172489658 45 + 1.329 1.224 -0.368
ENSG00000091409 E030 1.4606791 0.469884162 4.985889e-01 6.998311e-01 2 172489659 172489928 270 + 0.320 0.438 0.679
ENSG00000091409 E031 1.2703315 0.072765155 9.822383e-02   2 172490792 172490928 137 + 0.385 0.000 -14.756
ENSG00000091409 E032 1.2681187 0.012965083 8.061294e-02   2 172490929 172491023 95 + 0.385 0.000 -15.196
ENSG00000091409 E033 36.0101405 0.003757483 7.436486e-01 8.627569e-01 2 172491024 172491122 99 + 1.501 1.488 -0.045
ENSG00000091409 E034 33.9963121 0.006014326 7.247009e-01 8.509229e-01 2 172491221 172491331 111 + 1.463 1.497 0.118
ENSG00000091409 E035 28.4510913 0.001427809 9.866728e-01 9.951876e-01 2 172491425 172491523 99 + 1.399 1.407 0.027
ENSG00000091409 E036 26.9974176 0.039653427 7.067168e-01 8.397479e-01 2 172497975 172498100 126 + 1.371 1.417 0.157
ENSG00000091409 E037 6.1531743 0.078798541 3.866815e-02 1.512830e-01 2 172501772 172501901 130 + 0.686 1.039 1.366
ENSG00000091409 E038 267.4771344 0.001094193 2.577654e-08 1.102354e-06 2 172504091 172506459 2369 + 2.325 2.465 0.467