ENSG00000091129

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000351718 ENSG00000091129 HEK293_OSMI2_6hA HEK293_TMG_6hB NRCAM protein_coding protein_coding 2.618145 1.190668 3.279196 0.3169983 0.07617099 1.453897 1.1020637 0.4289207 1.56861600 0.09779263 0.36269816 1.846628 0.4259042 0.4038000 0.481500000 0.0777 9.128328e-01 2.528071e-07 FALSE TRUE
ENST00000522550 ENSG00000091129 HEK293_OSMI2_6hA HEK293_TMG_6hB NRCAM protein_coding processed_transcript 2.618145 1.190668 3.279196 0.3169983 0.07617099 1.453897 0.2969356 0.3337656 0.02892656 0.08083840 0.02892656 -3.142598 0.2095458 0.2872333 0.008433333 -0.2788 2.528071e-07 2.528071e-07   FALSE
MSTRG.30496.5 ENSG00000091129 HEK293_OSMI2_6hA HEK293_TMG_6hB NRCAM protein_coding   2.618145 1.190668 3.279196 0.3169983 0.07617099 1.453897 1.0048764 0.4055634 1.55590483 0.22455903 0.38237821 1.913856 0.2945792 0.2687000 0.472300000 0.2036 7.401087e-01 2.528071e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000091129 E001 0.1308682 0.032649190 0.18368043   7 108147623 108147625 3 - 0.000 0.197 12.251
ENSG00000091129 E002 0.3336024 0.024441170 0.04700244   7 108147626 108147648 23 - 0.000 0.332 13.270
ENSG00000091129 E003 0.6071052 0.019387492 0.05663254   7 108147649 108147661 13 - 0.072 0.434 3.245
ENSG00000091129 E004 7.7947884 0.152825016 0.02888991 0.12404670 7 108147662 108147945 284 - 0.717 1.205 1.837
ENSG00000091129 E005 14.9475159 0.304569784 0.04311731 0.16287726 7 108147946 108148116 171 - 0.939 1.477 1.916
ENSG00000091129 E006 80.4889164 1.234615078 0.30039264 0.54083923 7 108148117 108149951 1835 - 1.712 2.107 1.329
ENSG00000091129 E007 10.1914935 0.258599966 0.07438294 0.23351822 7 108149952 108150048 97 - 0.840 1.271 1.578
ENSG00000091129 E008 10.6366578 0.362167879 0.37310753 0.60661006 7 108150049 108150147 99 - 0.928 1.185 0.935
ENSG00000091129 E009 0.0000000       7 108150695 108150753 59 -      
ENSG00000091129 E010 0.0000000       7 108156387 108156448 62 -      
ENSG00000091129 E011 0.1426347 0.032840742 1.00000000   7 108156449 108156637 189 - 0.072 0.000 -8.981
ENSG00000091129 E012 9.3478210 0.103836483 0.85625427 0.92838279 7 108159463 108159541 79 - 0.927 1.038 0.411
ENSG00000091129 E013 12.5931606 0.002840044 0.28200130 0.52232384 7 108160361 108160492 132 - 1.081 1.054 -0.098
ENSG00000091129 E014 0.3150090 0.055714932 0.48232088   7 108166921 108167073 153 - 0.072 0.197 1.666
ENSG00000091129 E015 0.9231097 0.024927811 0.53984344   7 108168277 108168402 126 - 0.280 0.197 -0.657
ENSG00000091129 E016 0.0000000       7 108175322 108175357 36 -      
ENSG00000091129 E017 20.4533605 0.012366786 0.03031007 0.12829559 7 108176430 108176606 177 - 1.295 1.169 -0.447
ENSG00000091129 E018 0.0000000       7 108176707 108176773 67 -      
ENSG00000091129 E019 19.1880276 0.002334534 0.03323343 0.13667654 7 108177990 108178112 123 - 1.269 1.169 -0.356
ENSG00000091129 E020 0.1779838 0.059994008 1.00000000   7 108178113 108178114 2 - 0.073 0.000 -8.986
ENSG00000091129 E021 21.4575203 0.016478249 0.64160473 0.79788547 7 108180223 108180427 205 - 1.283 1.333 0.174
ENSG00000091129 E022 21.0151343 0.007490641 0.90143087 0.95260389 7 108181822 108181937 116 - 1.264 1.346 0.284
ENSG00000091129 E023 29.4646537 0.020222632 0.20203475 0.43212317 7 108182695 108182920 226 - 1.429 1.405 -0.083
ENSG00000091129 E024 15.4892369 0.002702460 0.14051304 0.34829948 7 108184241 108184311 71 - 1.170 1.115 -0.196
ENSG00000091129 E025 21.7650972 0.001610033 0.88029335 0.94140507 7 108184417 108184614 198 - 1.278 1.358 0.279
ENSG00000091129 E026 15.0754355 0.002602685 0.40551414 0.63270607 7 108189645 108189746 102 - 1.142 1.152 0.035
ENSG00000091129 E027 0.0000000       7 108191254 108191283 30 -      
ENSG00000091129 E028 17.5096846 0.002447925 0.61803786 0.78246455 7 108191729 108191853 125 - 1.165 1.300 0.477
ENSG00000091129 E029 20.3786983 0.003990597 0.19442962 0.42262753 7 108194024 108194171 148 - 1.270 1.247 -0.081
ENSG00000091129 E030 15.5748388 0.023131429 0.61353214 0.77928158 7 108194262 108194428 167 - 1.149 1.184 0.126
ENSG00000091129 E031 11.3183486 0.003639748 0.12192095 0.31894899 7 108195761 108195872 112 - 1.048 0.956 -0.338
ENSG00000091129 E032 6.8012176 0.091873238 0.23648439 0.47251526 7 108197956 108197994 39 - 0.856 0.712 -0.574
ENSG00000091129 E033 9.1086537 0.003654824 0.12616851 0.32576652 7 108197995 108198099 105 - 0.970 0.864 -0.401
ENSG00000091129 E034 0.0000000       7 108207228 108207527 300 -      
ENSG00000091129 E035 12.5881326 0.003082923 0.01814759 0.08952184 7 108207528 108207659 132 - 1.107 0.927 -0.661
ENSG00000091129 E036 17.2882526 0.009752141 0.24883880 0.48661846 7 108209421 108209605 185 - 1.201 1.171 -0.106
ENSG00000091129 E037 18.0401689 0.012420396 0.26901348 0.50878903 7 108223725 108223836 112 - 1.221 1.201 -0.072
ENSG00000091129 E038 6.5170567 0.197425902 0.97284791 0.98839350 7 108225645 108225701 57 - 0.806 0.858 0.203
ENSG00000091129 E039 18.6096802 0.002521164 0.12514131 0.32397629 7 108226208 108226378 171 - 1.248 1.201 -0.165
ENSG00000091129 E040 14.2144821 0.011456548 0.80929586 0.90177058 7 108231031 108231153 123 - 1.113 1.183 0.251
ENSG00000091129 E041 9.9257610 0.006707279 0.84720281 0.92341502 7 108232326 108232398 73 - 0.962 1.031 0.253
ENSG00000091129 E042 7.0928700 0.004752534 0.87195518 0.93697154 7 108232399 108232416 18 - 0.833 0.897 0.246
ENSG00000091129 E043 10.9911294 0.002926532 0.49676513 0.69873353 7 108232417 108232522 106 - 1.018 1.031 0.047
ENSG00000091129 E044 7.9478153 0.004596708 0.21365486 0.44594058 7 108234583 108234629 47 - 0.907 0.829 -0.303
ENSG00000091129 E045 7.6883781 0.004715910 0.02653877 0.11688434 7 108234630 108234688 59 - 0.926 0.700 -0.891
ENSG00000091129 E046 0.0000000       7 108237752 108237769 18 -      
ENSG00000091129 E047 10.6788084 0.037373273 0.00951845 0.05604701 7 108239959 108240170 212 - 1.064 0.746 -1.211
ENSG00000091129 E048 0.0000000       7 108243047 108243240 194 -      
ENSG00000091129 E049 6.4538259 0.006652628 0.36913153 0.60336542 7 108312665 108312731 67 - 0.833 0.789 -0.170
ENSG00000091129 E050 0.0000000       7 108313204 108313295 92 -      
ENSG00000091129 E051 0.0000000       7 108328421 108328655 235 -      
ENSG00000091129 E052 8.1280983 0.009089156 0.08476306 0.25426970 7 108399436 108399593 158 - 0.936 0.789 -0.567
ENSG00000091129 E053 4.2349321 0.058368595 0.96113323 0.98256305 7 108456243 108456436 194 - 0.650 0.742 0.383
ENSG00000091129 E054 0.0000000       7 108456670 108456717 48 -