ENSG00000091073

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000413936 ENSG00000091073 HEK293_OSMI2_6hA HEK293_TMG_6hB DTX2 protein_coding protein_coding 12.62895 18.96914 5.945246 3.080364 0.117723 -1.672182 1.4130056 1.87337029 0.28161601 0.93709892 0.28161601 -2.6911749 0.11257917 0.118366667 0.04583333 -0.072533333 7.589951e-01 1.48293e-14 FALSE TRUE
ENST00000430490 ENSG00000091073 HEK293_OSMI2_6hA HEK293_TMG_6hB DTX2 protein_coding protein_coding 12.62895 18.96914 5.945246 3.080364 0.117723 -1.672182 1.8999777 3.29719574 1.84652443 1.35368440 0.21748576 -0.8330041 0.15859167 0.161633333 0.30993333 0.148300000 2.815687e-01 1.48293e-14 FALSE TRUE
ENST00000465488 ENSG00000091073 HEK293_OSMI2_6hA HEK293_TMG_6hB DTX2 protein_coding retained_intron 12.62895 18.96914 5.945246 3.080364 0.117723 -1.672182 2.1373475 3.46543900 0.06181182 1.01969722 0.06181182 -5.5968300 0.11451250 0.174500000 0.01006667 -0.164433333 1.222638e-02 1.48293e-14 FALSE TRUE
ENST00000468546 ENSG00000091073 HEK293_OSMI2_6hA HEK293_TMG_6hB DTX2 protein_coding retained_intron 12.62895 18.96914 5.945246 3.080364 0.117723 -1.672182 0.5319605 0.72974455 0.26091631 0.51072030 0.09195888 -1.4491799 0.05055417 0.049766667 0.04390000 -0.005866667 9.099717e-01 1.48293e-14 FALSE TRUE
ENST00000492339 ENSG00000091073 HEK293_OSMI2_6hA HEK293_TMG_6hB DTX2 protein_coding processed_transcript 12.62895 18.96914 5.945246 3.080364 0.117723 -1.672182 0.1807096 0.04988973 0.40492317 0.04988973 0.20071848 2.7924636 0.01881250 0.002066667 0.06830000 0.066233333 1.927068e-02 1.48293e-14 TRUE FALSE
MSTRG.30107.1 ENSG00000091073 HEK293_OSMI2_6hA HEK293_TMG_6hB DTX2 protein_coding   12.62895 18.96914 5.945246 3.080364 0.117723 -1.672182 1.3175467 1.59204177 1.84201496 1.12709518 0.18305315 0.2091840 0.12054167 0.069500000 0.31126667 0.241766667 3.893990e-01 1.48293e-14 FALSE TRUE
MSTRG.30107.3 ENSG00000091073 HEK293_OSMI2_6hA HEK293_TMG_6hB DTX2 protein_coding   12.62895 18.96914 5.945246 3.080364 0.117723 -1.672182 2.6179537 4.22534491 0.00000000 0.50173843 0.00000000 -8.7263357 0.20627083 0.228533333 0.00000000 -0.228533333 1.482930e-14 1.48293e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000091073 E001 0.0000000       7 76461668 76461675 8 +      
ENSG00000091073 E002 0.2922838 0.0274424043 0.308852306   7 76461676 76461686 11 + 0.217 0.065 -2.016
ENSG00000091073 E003 0.4231520 0.0329307027 0.552523591   7 76461687 76461688 2 + 0.217 0.120 -1.020
ENSG00000091073 E004 0.9181700 0.0488971370 0.438240847   7 76461689 76461696 8 + 0.361 0.214 -1.023
ENSG00000091073 E005 0.9181700 0.0488971370 0.438240847   7 76461697 76461700 4 + 0.361 0.214 -1.023
ENSG00000091073 E006 1.9772392 0.0110054713 0.664639337 0.81278792 7 76461701 76461708 8 + 0.469 0.388 -0.429
ENSG00000091073 E007 2.1081074 0.0102288505 0.770506199 0.87897622 7 76461709 76461715 7 + 0.469 0.416 -0.278
ENSG00000091073 E008 2.1081074 0.0102288505 0.770506199 0.87897622 7 76461716 76461716 1 + 0.469 0.416 -0.278
ENSG00000091073 E009 2.2389755 0.0097622343 0.874413958 0.93842685 7 76461717 76461719 3 + 0.469 0.442 -0.141
ENSG00000091073 E010 14.4494956 0.0110095477 0.918865233 0.96164956 7 76461720 76461836 117 + 1.103 1.088 -0.053
ENSG00000091073 E011 0.1308682 0.0326491905 1.000000000   7 76462458 76462611 154 + 0.000 0.065 9.648
ENSG00000091073 E012 0.3447487 0.7130390438 1.000000000   7 76463445 76463544 100 + 0.000 0.124 9.909
ENSG00000091073 E013 5.1994812 0.1968194559 0.482135142 0.68850444 7 76463545 76463653 109 + 0.791 0.686 -0.427
ENSG00000091073 E014 8.5125665 0.0060400203 0.935203752 0.96977253 7 76463654 76463709 56 + 0.910 0.905 -0.019
ENSG00000091073 E015 0.2617363 0.0397006465 1.000000000   7 76470300 76470419 120 + 0.000 0.120 10.582
ENSG00000091073 E016 0.0000000       7 76472062 76472122 61 +      
ENSG00000091073 E017 2.0987077 0.0108647759 0.007550324 0.04725854 7 76476943 76477113 171 + 0.744 0.293 -2.238
ENSG00000091073 E018 5.3143896 0.0089414732 0.875943218 0.93922661 7 76477114 76477178 65 + 0.690 0.714 0.102
ENSG00000091073 E019 0.0000000       7 76478127 76478202 76 +      
ENSG00000091073 E020 0.0000000       7 76478975 76479120 146 +      
ENSG00000091073 E021 33.4860738 0.0015106653 0.583139866 0.75905846 7 76480421 76480509 89 + 1.409 1.451 0.146
ENSG00000091073 E022 85.1419683 0.0077406239 0.694686503 0.83209421 7 76480510 76480777 268 + 1.860 1.830 -0.101
ENSG00000091073 E023 0.2027342 0.0402450186 1.000000000   7 76480778 76480778 1 + 0.000 0.065 9.614
ENSG00000091073 E024 149.0183395 0.0007085448 0.050882137 0.18176182 7 76482508 76483147 640 + 2.133 2.069 -0.215
ENSG00000091073 E025 0.4397201 0.0364975620 0.551250779   7 76491997 76492152 156 + 0.217 0.120 -1.022
ENSG00000091073 E026 24.7923293 0.0271790714 0.648762511 0.80272557 7 76492153 76492253 101 + 1.267 1.336 0.241
ENSG00000091073 E027 10.0442339 0.1145173349 0.052923418 0.18652577 7 76497337 76497477 141 + 0.552 1.027 1.908
ENSG00000091073 E028 3.2425543 0.1426088088 0.973282865 0.98857058 7 76499802 76500440 639 + 0.557 0.540 -0.078
ENSG00000091073 E029 7.9341618 0.0898483566 0.626265159 0.78808931 7 76500441 76500443 3 + 0.791 0.891 0.391
ENSG00000091073 E030 26.9270726 0.0507278872 0.744432862 0.86332474 7 76500444 76500520 77 + 1.393 1.343 -0.172
ENSG00000091073 E031 1.4465823 0.0444507940 0.041428441 0.15843228 7 76501267 76501292 26 + 0.626 0.254 -2.022
ENSG00000091073 E032 6.6859503 0.3072093045 0.528335840 0.72086913 7 76501889 76502297 409 + 0.871 0.781 -0.355
ENSG00000091073 E033 75.7038335 0.0014210687 0.058751842 0.19996878 7 76502298 76502456 159 + 1.867 1.778 -0.299
ENSG00000091073 E034 2.9629646 0.0798406656 0.884274980 0.94355901 7 76502809 76502989 181 + 0.555 0.514 -0.191
ENSG00000091073 E035 1.2129700 0.1993642891 0.179670929   7 76503367 76503425 59 + 0.000 0.353 12.084
ENSG00000091073 E036 96.5671176 0.0006440747 0.354214381 0.59102899 7 76503426 76503587 162 + 1.931 1.894 -0.122
ENSG00000091073 E037 85.7784890 0.0005248359 0.094546995 0.27216758 7 76504356 76504445 90 + 1.783 1.863 0.271
ENSG00000091073 E038 187.0903543 0.0003666257 0.002596708 0.02094054 7 76505374 76505995 622 + 2.105 2.198 0.312