ENSG00000091039

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261183 ENSG00000091039 HEK293_OSMI2_6hA HEK293_TMG_6hB OSBPL8 protein_coding protein_coding 11.14066 0.9952315 22.6461 0.2399666 0.9200471 4.4943 0.8550265 0.00000000 3.306749 0.00000000 2.5788519 8.373626 0.04244583 0.00000000 0.15616667 0.15616667 0.75958641 0.02062243 FALSE TRUE
ENST00000393249 ENSG00000091039 HEK293_OSMI2_6hA HEK293_TMG_6hB OSBPL8 protein_coding protein_coding 11.14066 0.9952315 22.6461 0.2399666 0.9200471 4.4943 1.3832046 0.40585974 2.205272 0.36384952 0.5608745 2.413315 0.19191667 0.34710000 0.09716667 -0.24993333 0.89499072 0.02062243 FALSE TRUE
ENST00000393250 ENSG00000091039 HEK293_OSMI2_6hA HEK293_TMG_6hB OSBPL8 protein_coding protein_coding 11.14066 0.9952315 22.6461 0.2399666 0.9200471 4.4943 3.4032837 0.05317673 7.064234 0.05317673 0.4031048 6.807037 0.16646667 0.04116667 0.31420000 0.27303333 0.02062243 0.02062243 FALSE TRUE
ENST00000611266 ENSG00000091039 HEK293_OSMI2_6hA HEK293_TMG_6hB OSBPL8 protein_coding protein_coding 11.14066 0.9952315 22.6461 0.2399666 0.9200471 4.4943 4.1765269 0.53619505 7.346189 0.34276235 3.3481842 3.751470 0.51057083 0.61173333 0.31306667 -0.29866667 0.80917319 0.02062243 FALSE TRUE
MSTRG.7679.4 ENSG00000091039 HEK293_OSMI2_6hA HEK293_TMG_6hB OSBPL8 protein_coding   11.14066 0.9952315 22.6461 0.2399666 0.9200471 4.4943 0.6358050 0.00000000 1.905178 0.00000000 0.3922469 7.581335 0.03162917 0.00000000 0.08296667 0.08296667 0.03189701 0.02062243 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000091039 E001 0.0000000       12 76351797 76351799 3 -      
ENSG00000091039 E002 282.8127798 1.757038459 0.34025669 0.57818681 12 76351800 76353924 2125 - 2.057 2.519 1.541
ENSG00000091039 E003 255.3290316 1.735476299 0.47605416 0.68429327 12 76353925 76355835 1911 - 2.031 2.336 1.018
ENSG00000091039 E004 72.7410612 0.662817721 0.46936704 0.67959712 12 76355836 76356021 186 - 1.509 1.652 0.487
ENSG00000091039 E005 79.8643256 0.017107477 0.72159001 0.84910784 12 76356626 76356728 103 - 1.557 1.607 0.171
ENSG00000091039 E006 91.0337634 0.003220000 0.96821015 0.98596516 12 76358706 76358811 106 - 1.610 1.703 0.317
ENSG00000091039 E007 45.6233587 0.001663121 0.31185541 0.55222694 12 76369214 76369218 5 - 1.312 1.506 0.673
ENSG00000091039 E008 84.4890630 0.004826956 0.18848258 0.41505566 12 76369219 76369301 83 - 1.569 1.770 0.684
ENSG00000091039 E009 75.2706247 0.005220654 0.81686100 0.90637428 12 76369637 76369712 76 - 1.528 1.608 0.273
ENSG00000091039 E010 49.2625933 0.013082520 0.35852354 0.59460568 12 76369713 76369717 5 - 1.355 1.346 -0.031
ENSG00000091039 E011 89.4572752 0.010683696 0.22956825 0.46463309 12 76369718 76369822 105 - 1.606 1.593 -0.045
ENSG00000091039 E012 0.4868358 0.414228748 0.16540146   12 76371212 76371447 236 - 0.061 0.376 3.191
ENSG00000091039 E013 90.9422002 0.033725586 0.18811828 0.41456038 12 76371448 76371584 137 - 1.615 1.568 -0.159
ENSG00000091039 E014 0.4466850 0.024441170 1.00000000   12 76371585 76371862 278 - 0.087 0.000 -8.607
ENSG00000091039 E015 87.3860700 0.011859626 0.60736518 0.77512682 12 76373344 76373433 90 - 1.592 1.649 0.195
ENSG00000091039 E016 1.1586203 0.139943079 1.00000000   12 76373434 76373489 56 - 0.182 0.000 -9.847
ENSG00000091039 E017 90.1896558 0.009704327 0.34437921 0.58197759 12 76375273 76375370 98 - 1.607 1.623 0.055
ENSG00000091039 E018 91.7180037 0.008659245 0.11189707 0.30225208 12 76378452 76378550 99 - 1.618 1.576 -0.143
ENSG00000091039 E019 83.5755644 0.008514288 0.04202051 0.15998317 12 76384254 76384350 97 - 1.581 1.486 -0.328
ENSG00000091039 E020 0.3393995 0.026699537 0.94029942   12 76386030 76386167 138 - 0.060 0.000 -8.026
ENSG00000091039 E021 66.1029890 0.010495374 0.69734386 0.83383261 12 76386168 76386266 99 - 1.475 1.541 0.227
ENSG00000091039 E022 57.3068681 0.027311775 0.59234487 0.76516394 12 76386579 76386660 82 - 1.415 1.461 0.159
ENSG00000091039 E023 79.3439317 0.020626132 0.60935989 0.77646758 12 76389645 76389829 185 - 1.550 1.595 0.153
ENSG00000091039 E024 0.3393995 0.026699537 0.94029942   12 76389830 76389984 155 - 0.060 0.000 -8.026
ENSG00000091039 E025 0.2852693 0.222269261 0.67968791   12 76390281 76390419 139 - 0.059 0.000 -8.008
ENSG00000091039 E026 127.7236729 0.017709914 0.18818948 0.41465756 12 76390420 76390657 238 - 1.757 1.737 -0.066
ENSG00000091039 E027 94.2080306 0.013532658 0.01545980 0.07981972 12 76392581 76392752 172 - 1.634 1.485 -0.507
ENSG00000091039 E028 61.7028872 0.005637207 0.03033180 0.12836514 12 76394645 76394729 85 - 1.455 1.317 -0.478
ENSG00000091039 E029 0.5255656 0.233633550 0.12217187   12 76394730 76394737 8 - 0.060 0.387 3.284
ENSG00000091039 E030 80.2813205 0.018074041 0.02668256 0.11730947 12 76397694 76397855 162 - 1.566 1.419 -0.504
ENSG00000091039 E031 43.6243710 0.026478124 0.31341087 0.55364200 12 76397856 76397897 42 - 1.308 1.282 -0.091
ENSG00000091039 E032 32.0413291 0.051011881 0.58411729 0.75975108 12 76399873 76399880 8 - 1.179 1.209 0.105
ENSG00000091039 E033 58.7116068 0.036758341 0.43837710 0.65752180 12 76399881 76399974 94 - 1.429 1.437 0.028
ENSG00000091039 E034 36.4411395 0.038712230 0.77073660 0.87909733 12 76402689 76402698 10 - 1.227 1.286 0.206
ENSG00000091039 E035 48.9498798 0.029483576 0.67154489 0.81728020 12 76402699 76402723 25 - 1.349 1.397 0.164
ENSG00000091039 E036 47.3066880 0.023253066 0.32135437 0.56087732 12 76402724 76402755 32 - 1.338 1.317 -0.076
ENSG00000091039 E037 37.3955698 0.038968039 0.31281644 0.55315457 12 76402756 76402766 11 - 1.241 1.184 -0.202
ENSG00000091039 E038 65.5590183 0.022669903 0.18440084 0.40971162 12 76410564 76410634 71 - 1.476 1.422 -0.186
ENSG00000091039 E039 0.1779838 0.064414327 0.40184819   12 76422511 76423266 756 - 0.031 0.000 -7.029
ENSG00000091039 E040 60.7478517 0.023088026 0.33078386 0.56971742 12 76450851 76450892 42 - 1.443 1.440 -0.009
ENSG00000091039 E041 50.0903765 0.016485494 0.39341593 0.62308651 12 76450893 76450900 8 - 1.362 1.370 0.029
ENSG00000091039 E042 69.3981076 0.020414140 0.09472313 0.27247433 12 76450901 76450979 79 - 1.502 1.419 -0.286
ENSG00000091039 E043 25.2699230 0.001542781 0.08038275 0.24561147 12 76450980 76450988 9 - 1.094 0.907 -0.691
ENSG00000091039 E044 13.3946657 0.005717998 0.02310008 0.10626048 12 76459859 76459895 37 - 0.852 0.383 -2.110
ENSG00000091039 E045 0.0000000       12 76486035 76486108 74 -      
ENSG00000091039 E046 40.5270170 0.009101746 0.06339868 0.21034790 12 76487510 76487549 40 - 1.282 1.136 -0.517
ENSG00000091039 E047 37.7770495 0.002477761 0.05214862 0.18474322 12 76487550 76487618 69 - 1.253 1.090 -0.582
ENSG00000091039 E048 0.0000000       12 76534234 76534281 48 -      
ENSG00000091039 E049 0.0000000       12 76537004 76537041 38 -      
ENSG00000091039 E050 0.0000000       12 76537957 76537986 30 -      
ENSG00000091039 E051 40.3555761 0.016110557 0.17748428 0.40041158 12 76559397 76559809 413 - 1.275 1.181 -0.330