ENSG00000090989

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000346134 ENSG00000090989 HEK293_OSMI2_6hA HEK293_TMG_6hB EXOC1 protein_coding protein_coding 8.713692 2.963895 15.01985 0.5546737 1.010058 2.337405 1.5269204 0.7203746 3.451532 0.1688439 0.6081626 2.244702 0.13787917 0.2425000 0.2333333 -0.009166667 9.853893e-01 2.419606e-05 FALSE TRUE
ENST00000349598 ENSG00000090989 HEK293_OSMI2_6hA HEK293_TMG_6hB EXOC1 protein_coding protein_coding 8.713692 2.963895 15.01985 0.5546737 1.010058 2.337405 0.8946781 0.0000000 1.700649 0.0000000 1.7006491 7.418400 0.12103750 0.0000000 0.1077667 0.107766667 1.000000e+00 2.419606e-05 FALSE TRUE
ENST00000381295 ENSG00000090989 HEK293_OSMI2_6hA HEK293_TMG_6hB EXOC1 protein_coding protein_coding 8.713692 2.963895 15.01985 0.5546737 1.010058 2.337405 1.9528325 0.0000000 3.627268 0.0000000 1.1690390 8.506711 0.21450000 0.0000000 0.2338000 0.233800000 2.419606e-05 2.419606e-05 FALSE TRUE
ENST00000506936 ENSG00000090989 HEK293_OSMI2_6hA HEK293_TMG_6hB EXOC1 protein_coding retained_intron 8.713692 2.963895 15.01985 0.5546737 1.010058 2.337405 0.3948136 0.0000000 0.000000 0.0000000 0.0000000 0.000000 0.09527917 0.0000000 0.0000000 0.000000000   2.419606e-05   FALSE
MSTRG.24911.2 ENSG00000090989 HEK293_OSMI2_6hA HEK293_TMG_6hB EXOC1 protein_coding   8.713692 2.963895 15.01985 0.5546737 1.010058 2.337405 3.4534171 2.0710540 5.360696 0.4095279 1.6389664 1.367795 0.37391667 0.6950333 0.3687333 -0.326300000 2.759888e-01 2.419606e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000090989 E001 0.1426347 0.0313818715 1.0000000   4 55853648 55853660 13 + 0.065 0.000 -8.340
ENSG00000090989 E002 2.0118891 0.0102268616 0.6167306 0.78154193 4 55853661 55853674 14 + 0.444 0.358 -0.475
ENSG00000090989 E003 7.4710495 0.0238311296 0.7577283 0.87124680 4 55853675 55853738 64 + 0.862 0.830 -0.125
ENSG00000090989 E004 22.3705581 0.0293787753 0.7974236 0.89485356 4 55853739 55853797 59 + 1.285 1.266 -0.068
ENSG00000090989 E005 33.6091453 0.0254697690 0.9155959 0.95995231 4 55853798 55853953 156 + 1.444 1.475 0.107
ENSG00000090989 E006 27.6709218 0.0154451929 0.6399572 0.79686762 4 55858314 55858338 25 + 1.374 1.347 -0.092
ENSG00000090989 E007 39.4811905 0.0047016057 0.2510723 0.48912427 4 55858339 55858447 109 + 1.533 1.466 -0.231
ENSG00000090989 E008 41.8474653 0.0017101882 0.8792602 0.94092752 4 55860411 55860541 131 + 1.544 1.552 0.027
ENSG00000090989 E009 51.6198177 0.0162256101 0.2304161 0.46556486 4 55864227 55864386 160 + 1.647 1.572 -0.257
ENSG00000090989 E010 73.1939332 0.0200176244 0.1341533 0.33833283 4 55868336 55868523 188 + 1.798 1.704 -0.319
ENSG00000090989 E011 0.8096672 0.0971199392 1.0000000   4 55868524 55868753 230 + 0.218 0.214 -0.034
ENSG00000090989 E012 76.9936638 0.0058157853 0.2467758 0.48445484 4 55870678 55870905 228 + 1.812 1.767 -0.151
ENSG00000090989 E013 48.5131862 0.0021689933 0.6928840 0.83096856 4 55871101 55871233 133 + 1.609 1.603 -0.020
ENSG00000090989 E014 47.6071886 0.0071876304 0.7895338 0.89025298 4 55871849 55871958 110 + 1.589 1.630 0.139
ENSG00000090989 E015 68.3015212 0.0009408383 0.5678674 0.74870497 4 55877917 55878066 150 + 1.762 1.749 -0.043
ENSG00000090989 E016 1.1496142 0.1246581231 0.6339642   4 55882727 55883767 1041 + 0.258 0.360 0.671
ENSG00000090989 E017 0.1779838 0.0695811613 1.0000000   4 55883768 55883822 55 + 0.065 0.000 -8.341
ENSG00000090989 E018 58.5681807 0.0468134666 0.8504821 0.92529672 4 55883823 55883928 106 + 1.696 1.647 -0.167
ENSG00000090989 E019 2.2125982 0.0102417513 0.5337397 0.72471853 4 55888810 55888887 78 + 0.469 0.359 -0.599
ENSG00000090989 E020 22.9504059 0.1073989601 0.2979621 0.53843260 4 55888888 55888932 45 + 1.335 1.093 -0.857
ENSG00000090989 E021 67.5772390 0.9354197571 0.4544505 0.66910124 4 55890223 55890386 164 + 1.722 1.825 0.347
ENSG00000090989 E022 57.0823053 0.0302312398 0.4955741 0.69786044 4 55891315 55891422 108 + 1.665 1.717 0.174
ENSG00000090989 E023 1.5841077 0.3533811455 0.8959897 0.94981056 4 55892615 55892634 20 + 0.352 0.370 0.104
ENSG00000090989 E024 51.9936238 0.0015386758 0.3947541 0.62409995 4 55892635 55892711 77 + 1.648 1.611 -0.127
ENSG00000090989 E025 82.9262698 0.0018326262 0.1918799 0.41922635 4 55893552 55893780 229 + 1.846 1.801 -0.154
ENSG00000090989 E026 78.6148466 0.0298675559 0.4460872 0.66279260 4 55896717 55896900 184 + 1.818 1.790 -0.094
ENSG00000090989 E027 85.8988350 0.0005614636 0.2749162 0.51490649 4 55899685 55899884 200 + 1.842 1.906 0.217
ENSG00000090989 E028 0.7908862 0.0182389053 1.0000000   4 55900559 55900692 134 + 0.217 0.215 -0.017
ENSG00000090989 E029 0.2852693 0.1701334715 1.0000000   4 55902127 55902343 217 + 0.121 0.000 -9.322
ENSG00000090989 E030 70.8317005 0.9250319352 0.3299869 0.56894490 4 55902344 55902538 195 + 1.712 1.927 0.727
ENSG00000090989 E031 132.9821259 0.0068736254 0.0175116 0.08733072 4 55904343 55905086 744 + 2.005 2.148 0.480