ENSG00000090971

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000205194 ENSG00000090971 HEK293_OSMI2_6hA HEK293_TMG_6hB NAT14 protein_coding protein_coding 86.42772 141.685 41.90527 22.91955 2.10195 -1.757241 60.186237 105.11655 22.456918 20.2568109 1.3386128 -2.2262530 0.67727917 0.73300000 0.53546667 -0.19753333 0.001965764 0.001965764 FALSE TRUE
ENST00000591590 ENSG00000090971 HEK293_OSMI2_6hA HEK293_TMG_6hB NAT14 protein_coding protein_coding 86.42772 141.685 41.90527 22.91955 2.10195 -1.757241 7.064178 11.65139 4.024411 1.7496455 0.3816422 -1.5313103 0.08677083 0.08276667 0.09643333 0.01366667 0.811539399 0.001965764   FALSE
MSTRG.17723.3 ENSG00000090971 HEK293_OSMI2_6hA HEK293_TMG_6hB NAT14 protein_coding   86.42772 141.685 41.90527 22.91955 2.10195 -1.757241 18.476627 23.52697 15.193979 0.7548722 0.7821939 -0.6304797 0.22745000 0.17430000 0.36306667 0.18876667 0.003390294 0.001965764   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000090971 E001 8.802065 0.004387406 0.4321168190 0.652829927 19 55484987 55485187 201 + 0.961 0.856 -0.398
ENSG00000090971 E002 7.285164 0.004374784 0.9086336048 0.956442352 19 55485188 55485194 7 + 0.791 0.811 0.079
ENSG00000090971 E003 273.661553 0.956019186 0.4460574286 0.662774396 19 55485195 55485222 28 + 2.206 2.316 0.366
ENSG00000090971 E004 380.581374 1.093558721 0.4726353267 0.681945888 19 55485223 55485233 11 + 2.354 2.458 0.347
ENSG00000090971 E005 482.021788 1.169673715 0.4597391736 0.672938163 19 55485234 55485258 25 + 2.437 2.563 0.420
ENSG00000090971 E006 571.629584 1.232318549 0.4645970212 0.676312220 19 55485661 55485718 58 + 2.507 2.637 0.434
ENSG00000090971 E007 456.910434 1.171084774 0.4899638532 0.693971071 19 55485719 55485729 11 + 2.439 2.536 0.324
ENSG00000090971 E008 557.366790 1.228893990 0.4724743319 0.681858426 19 55485730 55485780 51 + 2.503 2.625 0.407
ENSG00000090971 E009 161.870449 0.025675650 0.0206718360 0.098247973 19 55485781 55486407 627 + 2.220 2.041 -0.599
ENSG00000090971 E010 281.062412 0.015718961 0.1209923783 0.317453632 19 55486408 55486421 14 + 2.238 2.326 0.294
ENSG00000090971 E011 707.690970 0.007470930 0.0002244841 0.002941782 19 55486422 55486860 439 + 2.556 2.736 0.601
ENSG00000090971 E012 494.322971 0.020267013 0.3776725398 0.610329959 19 55486861 55487053 193 + 2.593 2.549 -0.144
ENSG00000090971 E013 679.557229 0.028364522 0.2917508388 0.532426392 19 55487054 55487128 75 + 2.747 2.684 -0.211
ENSG00000090971 E014 826.931744 0.026906311 0.0726101054 0.230014847 19 55487129 55487233 105 + 2.871 2.760 -0.370
ENSG00000090971 E015 653.684076 0.021392416 0.0293333244 0.125386321 19 55487234 55487277 44 + 2.783 2.655 -0.427
ENSG00000090971 E016 756.445586 0.026307763 0.0805754712 0.245992551 19 55487278 55487568 291 + 2.830 2.722 -0.359