ENSG00000090932

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000205143 ENSG00000090932 HEK293_OSMI2_6hA HEK293_TMG_6hB DLL3 protein_coding protein_coding 8.385236 15.1826 2.74196 3.53882 0.2804965 -2.464837 1.9965475 3.2824648 0.7735541 0.6145753 0.1126007 -2.071063 0.2566750 0.22233333 0.2807667 0.05843333 0.66126623 0.01559805 FALSE  
ENST00000356433 ENSG00000090932 HEK293_OSMI2_6hA HEK293_TMG_6hB DLL3 protein_coding protein_coding 8.385236 15.1826 2.74196 3.53882 0.2804965 -2.464837 5.9384147 11.0177312 1.9562386 2.9644180 0.2120488 -2.487626 0.6957917 0.71183333 0.7137333 0.00190000 1.00000000 0.01559805 FALSE  
MSTRG.17135.3 ENSG00000090932 HEK293_OSMI2_6hA HEK293_TMG_6hB DLL3 protein_coding   8.385236 15.1826 2.74196 3.53882 0.2804965 -2.464837 0.4382124 0.8527805 0.0000000 0.2180500 0.0000000 -6.430922 0.0454625 0.06366667 0.0000000 -0.06366667 0.01559805 0.01559805 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000090932 E001 0.4054685 0.5194041132 1.00000000   19 39498895 39498946 52 + 0.000 0.104 9.396
ENSG00000090932 E002 0.4054685 0.5194041132 1.00000000   19 39498947 39498966 20 + 0.000 0.104 10.130
ENSG00000090932 E003 0.4054685 0.5194041132 1.00000000   19 39498967 39498967 1 + 0.000 0.104 10.130
ENSG00000090932 E004 0.5834523 0.3822471156 0.38689249   19 39498968 39499043 76 + 0.263 0.103 -1.641
ENSG00000090932 E005 0.0000000       19 39499044 39499054 11 +      
ENSG00000090932 E006 1.0287093 0.1807987952 0.85957276   19 39499192 39499473 282 + 0.261 0.215 -0.361
ENSG00000090932 E007 0.4756169 0.1772174267 1.00000000   19 39500615 39500672 58 + 0.000 0.140 10.893
ENSG00000090932 E008 0.6536007 0.1574640121 0.54334961   19 39502815 39503057 243 + 0.261 0.140 -1.117
ENSG00000090932 E009 1.1843278 0.0331321075 0.34278848   19 39504071 39504288 218 + 0.000 0.277 12.614
ENSG00000090932 E010 1.9290082 0.0457313708 0.66491766 0.81298193 19 39505229 39505451 223 + 0.260 0.358 0.641
ENSG00000090932 E011 0.6839606 0.0193874923 0.51050878   19 39505452 39505653 202 + 0.260 0.140 -1.106
ENSG00000090932 E012 14.8696763 0.0170354408 0.09681304 0.27613933 19 39507039 39507311 273 + 0.828 1.085 0.962
ENSG00000090932 E013 317.8490898 0.0006648274 0.01017657 0.05887534 19 39507312 39507618 307 + 2.283 2.351 0.226
ENSG00000090932 E014 3.6442508 0.1045305763 0.20561244 0.43658067 19 39507619 39507714 96 + 0.260 0.558 1.670
ENSG00000090932 E015 244.8867057 0.0002925593 0.67646709 0.82051412 19 39507830 39507914 85 + 2.238 2.230 -0.029
ENSG00000090932 E016 72.2362134 0.0034602286 0.02178100 0.10186762 19 39507915 39508251 337 + 1.818 1.678 -0.471
ENSG00000090932 E017 238.1313660 0.0003473984 0.11554472 0.30838376 19 39508252 39508607 356 + 2.253 2.211 -0.140