ENSG00000090686

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000308271 ENSG00000090686 HEK293_OSMI2_6hA HEK293_TMG_6hB USP48 protein_coding protein_coding 34.51794 20.31305 50.83301 2.726123 1.682977 1.322932 2.030438 1.832508 0.9667087 0.4654533 0.1722383 -0.9156706 0.07454583 0.08706667 0.01883333 -0.06823333 7.301905e-05 3.759967e-14 FALSE TRUE
ENST00000374732 ENSG00000090686 HEK293_OSMI2_6hA HEK293_TMG_6hB USP48 protein_coding protein_coding 34.51794 20.31305 50.83301 2.726123 1.682977 1.322932 2.485763 1.283959 4.6536950 0.2462106 0.2312782 1.8496810 0.07120000 0.06973333 0.09146667 0.02173333 7.688587e-01 3.759967e-14 FALSE TRUE
ENST00000421625 ENSG00000090686 HEK293_OSMI2_6hA HEK293_TMG_6hB USP48 protein_coding protein_coding 34.51794 20.31305 50.83301 2.726123 1.682977 1.322932 3.390192 1.398694 6.1337862 0.1685037 0.3293157 2.1247692 0.08905833 0.06943333 0.12100000 0.05156667 6.380562e-02 3.759967e-14 FALSE TRUE
ENST00000487880 ENSG00000090686 HEK293_OSMI2_6hA HEK293_TMG_6hB USP48 protein_coding processed_transcript 34.51794 20.31305 50.83301 2.726123 1.682977 1.322932 2.506064 0.508361 5.4557889 0.2402235 0.5468636 3.3984006 0.05674583 0.02473333 0.10696667 0.08223333 1.441938e-02 3.759967e-14 FALSE FALSE
ENST00000526044 ENSG00000090686 HEK293_OSMI2_6hA HEK293_TMG_6hB USP48 protein_coding protein_coding 34.51794 20.31305 50.83301 2.726123 1.682977 1.322932 3.832729 1.507669 5.1379706 1.0537786 0.6567537 1.7621470 0.10253750 0.07136667 0.10050000 0.02913333 8.409112e-01 3.759967e-14 FALSE FALSE
MSTRG.500.10 ENSG00000090686 HEK293_OSMI2_6hA HEK293_TMG_6hB USP48 protein_coding   34.51794 20.31305 50.83301 2.726123 1.682977 1.322932 4.322328 5.183980 2.3683651 0.8970346 0.7013312 -1.1268702 0.17962500 0.25203333 0.04756667 -0.20446667 1.317721e-03 3.759967e-14 FALSE TRUE
MSTRG.500.4 ENSG00000090686 HEK293_OSMI2_6hA HEK293_TMG_6hB USP48 protein_coding   34.51794 20.31305 50.83301 2.726123 1.682977 1.322932 5.123124 3.347697 3.8545341 0.7020848 1.0170991 0.2028223 0.13947917 0.16313333 0.07723333 -0.08590000 3.111114e-01 3.759967e-14 FALSE TRUE
MSTRG.500.5 ENSG00000090686 HEK293_OSMI2_6hA HEK293_TMG_6hB USP48 protein_coding   34.51794 20.31305 50.83301 2.726123 1.682977 1.322932 1.170253 0.000000 5.9508447 0.0000000 1.2697516 9.2193730 0.02467500 0.00000000 0.11590000 0.11590000 3.759967e-14 3.759967e-14 FALSE TRUE
MSTRG.500.9 ENSG00000090686 HEK293_OSMI2_6hA HEK293_TMG_6hB USP48 protein_coding   34.51794 20.31305 50.83301 2.726123 1.682977 1.322932 7.929939 4.490613 13.1206903 0.7381612 0.9439823 1.5447494 0.21286250 0.21976667 0.25750000 0.03773333 6.434504e-01 3.759967e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000090686 E001 9.9135418 0.0033108507 1.845434e-03 1.602481e-02 1 21678298 21678902 605 - 0.878 1.204 1.193
ENSG00000090686 E002 66.7750756 0.0006552741 3.666327e-05 6.401014e-04 1 21678903 21679185 283 - 1.740 1.923 0.618
ENSG00000090686 E003 6.7718491 0.0048737151 1.108304e-01 3.003482e-01 1 21679186 21679190 5 - 0.785 0.982 0.751
ENSG00000090686 E004 24.7564218 0.0018326255 6.916449e-02 2.231048e-01 1 21679191 21679198 8 - 1.335 1.467 0.456
ENSG00000090686 E005 188.1092774 0.0005069323 4.009599e-04 4.740477e-03 1 21679199 21679366 168 - 2.224 2.323 0.332
ENSG00000090686 E006 169.6568142 0.0023158446 2.147600e-04 2.838888e-03 1 21679367 21679439 73 - 2.164 2.297 0.444
ENSG00000090686 E007 115.3966582 0.0004085531 1.260463e-06 3.471546e-05 1 21680808 21680834 27 - 1.984 2.149 0.554
ENSG00000090686 E008 4.3707693 0.0596628708 6.413384e-01 7.977119e-01 1 21680835 21681252 418 - 0.689 0.759 0.288
ENSG00000090686 E009 6.6414393 0.4125320191 7.075619e-01 8.402876e-01 1 21685892 21687190 1299 - 0.870 0.874 0.017
ENSG00000090686 E010 129.2985919 0.0003363113 3.091196e-07 1.012256e-05 1 21687191 21687239 49 - 2.034 2.198 0.550
ENSG00000090686 E011 172.1973849 0.0002771069 5.224522e-09 2.614925e-07 1 21689974 21690099 126 - 2.157 2.320 0.544
ENSG00000090686 E012 197.3677184 0.0002728891 2.095308e-04 2.778631e-03 1 21695066 21695221 156 - 2.245 2.343 0.328
ENSG00000090686 E013 188.6117976 0.0003390378 1.656908e-04 2.285793e-03 1 21701498 21701602 105 - 2.224 2.327 0.343
ENSG00000090686 E014 169.9286381 0.0016936914 7.649628e-04 7.986097e-03 1 21703512 21703618 107 - 2.175 2.289 0.381
ENSG00000090686 E015 200.4236732 0.0028276133 5.737903e-05 9.381226e-04 1 21704262 21704392 131 - 2.229 2.374 0.483
ENSG00000090686 E016 0.0000000       1 21704393 21704615 223 -      
ENSG00000090686 E017 180.8374727 0.0025891424 6.560827e-05 1.050419e-03 1 21705727 21705837 111 - 2.184 2.326 0.472
ENSG00000090686 E018 130.7190713 0.0006242686 1.128625e-03 1.088087e-02 1 21706126 21706187 62 - 2.059 2.168 0.363
ENSG00000090686 E019 181.1347407 0.0006349557 1.536380e-01 3.675030e-01 1 21706467 21706589 123 - 2.227 2.269 0.142
ENSG00000090686 E020 167.7455107 0.0030708293 4.291863e-01 6.504008e-01 1 21706744 21706868 125 - 2.199 2.227 0.094
ENSG00000090686 E021 1.6118719 0.0115948639 3.833086e-01 6.149762e-01 1 21706869 21706907 39 - 0.345 0.497 0.820
ENSG00000090686 E022 0.1779838 0.0349079262 8.519351e-01   1 21715124 21715388 265 - 0.095 0.000 -9.564
ENSG00000090686 E023 128.1657226 0.0004820632 7.720248e-01 8.798044e-01 1 21715389 21715457 69 - 2.097 2.089 -0.028
ENSG00000090686 E024 152.3007050 0.0003920341 5.067309e-01 7.054289e-01 1 21721036 21721163 128 - 2.161 2.183 0.072
ENSG00000090686 E025 48.4250064 0.0008897716 3.511126e-01 5.882463e-01 1 21721164 21721166 3 - 1.662 1.712 0.170
ENSG00000090686 E026 144.8034790 0.0053100344 6.082363e-01 7.757547e-01 1 21721650 21721764 115 - 2.142 2.163 0.069
ENSG00000090686 E027 125.6151139 0.0003340838 2.574556e-01 4.961912e-01 1 21723898 21723971 74 - 2.101 2.065 -0.120
ENSG00000090686 E028 144.9439876 0.0003100996 7.839951e-01 8.868873e-01 1 21723972 21724095 124 - 2.153 2.147 -0.021
ENSG00000090686 E029 55.4117601 0.1263861919 9.836390e-02 2.789186e-01 1 21724096 21724911 816 - 1.818 1.543 -0.933
ENSG00000090686 E030 24.3598901 0.0583610306 4.927038e-03 3.423866e-02 1 21724912 21725119 208 - 1.498 1.085 -1.451
ENSG00000090686 E031 14.8263311 0.0046955478 9.565044e-04 9.557480e-03 1 21726491 21726570 80 - 1.279 0.940 -1.222
ENSG00000090686 E032 88.8033389 0.0043509324 7.767451e-06 1.685310e-04 1 21727851 21728569 719 - 2.008 1.775 -0.783
ENSG00000090686 E033 122.3879271 0.0055634385 5.365894e-01 7.267518e-01 1 21728570 21728611 42 - 2.084 2.057 -0.091
ENSG00000090686 E034 185.4143488 0.0002337579 4.908695e-03 3.414296e-02 1 21728612 21728719 108 - 2.282 2.206 -0.252
ENSG00000090686 E035 226.4478715 0.0002107762 4.789336e-04 5.485638e-03 1 21729704 21729829 126 - 2.372 2.287 -0.284
ENSG00000090686 E036 84.2517978 0.0005656394 3.009296e-04 3.739556e-03 1 21729830 21729832 3 - 1.968 1.820 -0.499
ENSG00000090686 E037 0.0000000       1 21732664 21732761 98 -      
ENSG00000090686 E038 0.1614157 0.0333005722 8.521981e-01   1 21732762 21732836 75 - 0.094 0.000 -9.562
ENSG00000090686 E039 3.9038688 0.0062073687 2.743406e-02 1.196071e-01 1 21736430 21736445 16 - 0.785 0.433 -1.574
ENSG00000090686 E040 244.0265510 0.0002076924 9.160767e-09 4.341917e-07 1 21736446 21736625 180 - 2.421 2.283 -0.461
ENSG00000090686 E041 158.3530917 0.0003284699 8.390839e-05 1.291658e-03 1 21747067 21747149 83 - 2.226 2.108 -0.394
ENSG00000090686 E042 169.6929284 0.0002924208 6.635396e-05 1.060558e-03 1 21748138 21748271 134 - 2.256 2.140 -0.385
ENSG00000090686 E043 148.7516476 0.0002754823 3.084302e-05 5.533333e-04 1 21751507 21751615 109 - 2.203 2.075 -0.428
ENSG00000090686 E044 151.3066772 0.0011819519 4.155455e-04 4.882667e-03 1 21752527 21752651 125 - 2.208 2.090 -0.396
ENSG00000090686 E045 92.8868319 0.0011317961 2.336637e-03 1.929413e-02 1 21752992 21753006 15 - 2.000 1.878 -0.413
ENSG00000090686 E046 102.6057875 0.0022261082 8.793983e-03 5.292231e-02 1 21753007 21753034 28 - 2.037 1.928 -0.366
ENSG00000090686 E047 152.5792422 0.0003891944 2.286828e-06 5.870839e-05 1 21753035 21753119 85 - 2.219 2.073 -0.488
ENSG00000090686 E048 181.9480383 0.0005734264 1.274797e-07 4.621900e-06 1 21756546 21756702 157 - 2.299 2.144 -0.518
ENSG00000090686 E049 0.1779838 0.0349079262 8.519351e-01   1 21757461 21757662 202 - 0.095 0.000 -9.564
ENSG00000090686 E050 119.1758777 0.0003584770 5.441265e-06 1.240838e-04 1 21757663 21757783 121 - 2.118 1.961 -0.528
ENSG00000090686 E051 0.1723744 0.0424680485 2.776842e-01   1 21781858 21782020 163 - 0.000 0.155 11.170
ENSG00000090686 E052 63.7782920 0.0021656862 7.526822e-01 8.683934e-01 1 21782824 21782891 68 - 1.807 1.793 -0.045
ENSG00000090686 E053 46.9761938 0.0079737528 6.649665e-02 2.171832e-01 1 21782892 21782977 86 - 1.621 1.746 0.424
ENSG00000090686 E054 34.6639688 0.0105369440 3.340208e-03 2.542442e-02 1 21782978 21783606 629 - 1.444 1.673 0.783