ENSG00000090621

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372856 ENSG00000090621 HEK293_OSMI2_6hA HEK293_TMG_6hB PABPC4 protein_coding protein_coding 159.8563 190.8976 141.8165 32.22013 4.430489 -0.4287474 9.295823 13.791929 0.000000 3.7920192 0.0000000 -10.430654180 0.05489167 0.06926667 0.00000000 -0.06926667 8.179803e-27 8.179803e-27 FALSE TRUE
ENST00000372857 ENSG00000090621 HEK293_OSMI2_6hA HEK293_TMG_6hB PABPC4 protein_coding protein_coding 159.8563 190.8976 141.8165 32.22013 4.430489 -0.4287474 17.406747 22.416889 14.017241 3.4329302 0.8457026 -0.676998177 0.11452917 0.11966667 0.09906667 -0.02060000 7.526967e-01 8.179803e-27 FALSE TRUE
ENST00000372862 ENSG00000090621 HEK293_OSMI2_6hA HEK293_TMG_6hB PABPC4 protein_coding protein_coding 159.8563 190.8976 141.8165 32.22013 4.430489 -0.4287474 15.837773 16.707412 16.788980 1.7348076 1.3262899 0.007022164 0.10030833 0.09076667 0.11806667 0.02730000 5.763166e-01 8.179803e-27 FALSE TRUE
ENST00000421687 ENSG00000090621 HEK293_OSMI2_6hA HEK293_TMG_6hB PABPC4 protein_coding protein_coding 159.8563 190.8976 141.8165 32.22013 4.430489 -0.4287474 8.886585 6.646093 15.917630 1.6135354 3.6348856 1.258784052 0.06093750 0.03370000 0.11130000 0.07760000 5.832363e-03 8.179803e-27 FALSE TRUE
ENST00000470443 ENSG00000090621 HEK293_OSMI2_6hA HEK293_TMG_6hB PABPC4 protein_coding nonsense_mediated_decay 159.8563 190.8976 141.8165 32.22013 4.430489 -0.4287474 3.697766 0.000000 11.035665 0.0000000 1.9647588 10.109264559 0.02618333 0.00000000 0.07876667 0.07876667 1.677068e-23 8.179803e-27 FALSE TRUE
ENST00000676523 ENSG00000090621 HEK293_OSMI2_6hA HEK293_TMG_6hB PABPC4 protein_coding retained_intron 159.8563 190.8976 141.8165 32.22013 4.430489 -0.4287474 9.084194 7.675715 11.273413 2.8597415 0.8497843 0.553952157 0.06247083 0.04960000 0.07926667 0.02966667 6.080809e-01 8.179803e-27 TRUE TRUE
ENST00000678625 ENSG00000090621 HEK293_OSMI2_6hA HEK293_TMG_6hB PABPC4 protein_coding protein_coding 159.8563 190.8976 141.8165 32.22013 4.430489 -0.4287474 10.847003 18.918552 8.468243 7.5307460 1.4660606 -1.158726932 0.06532500 0.08933333 0.05980000 -0.02953333 8.950433e-01 8.179803e-27 FALSE TRUE
MSTRG.918.6 ENSG00000090621 HEK293_OSMI2_6hA HEK293_TMG_6hB PABPC4 protein_coding   159.8563 190.8976 141.8165 32.22013 4.430489 -0.4287474 24.320665 39.838205 18.988149 15.1040623 3.0387692 -1.068655879 0.13837500 0.19070000 0.13540000 -0.05530000 8.708392e-01 8.179803e-27 FALSE TRUE
MSTRG.918.7 ENSG00000090621 HEK293_OSMI2_6hA HEK293_TMG_6hB PABPC4 protein_coding   159.8563 190.8976 141.8165 32.22013 4.430489 -0.4287474 13.987802 17.775576 10.906129 0.1301238 0.6001541 -0.704246438 0.09003750 0.09976667 0.07680000 -0.02296667 7.896310e-01 8.179803e-27 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000090621 E001 1.3266026 0.0150749397 8.545514e-01   1 39560709 39560813 105 - 0.372 0.333 -0.229
ENSG00000090621 E002 0.9762444 0.0156245889 9.599918e-01   1 39560814 39560815 2 - 0.279 0.284 0.033
ENSG00000090621 E003 4.0417998 0.0068552716 1.215951e-02 6.710751e-02 1 39560816 39560820 5 - 0.371 0.784 1.910
ENSG00000090621 E004 57.2779510 0.0375413234 3.249932e-01 5.642188e-01 1 39560821 39560836 16 - 1.676 1.767 0.309
ENSG00000090621 E005 122.4771141 0.0080915321 6.510876e-02 2.141476e-01 1 39560837 39560844 8 - 1.999 2.095 0.320
ENSG00000090621 E006 143.3693845 0.0062673074 8.444398e-03 5.135373e-02 1 39560845 39560856 12 - 2.045 2.172 0.424
ENSG00000090621 E007 145.4804789 0.0081288781 2.800589e-02 1.212750e-01 1 39560857 39560857 1 - 2.061 2.175 0.381
ENSG00000090621 E008 1229.1478744 0.0046156095 6.070643e-01 7.749292e-01 1 39560858 39561122 265 - 3.056 3.069 0.042
ENSG00000090621 E009 33.5717955 0.1742152142 8.928338e-02 2.624396e-01 1 39561123 39561273 151 - 1.694 1.386 -1.052
ENSG00000090621 E010 61.4344345 0.1495813070 2.625158e-02 1.160780e-01 1 39561274 39561551 278 - 1.990 1.597 -1.326
ENSG00000090621 E011 39.9254768 0.1493421532 7.198721e-02 2.287842e-01 1 39561552 39561684 133 - 1.772 1.453 -1.085
ENSG00000090621 E012 595.4169893 0.0061700310 9.509256e-01 9.774301e-01 1 39561685 39561686 2 - 2.754 2.749 -0.016
ENSG00000090621 E013 761.0944044 0.0066415794 7.871312e-01 8.888422e-01 1 39561687 39561727 41 - 2.855 2.858 0.008
ENSG00000090621 E014 816.6651713 0.0075266569 7.713415e-01 8.794273e-01 1 39561728 39561787 60 - 2.885 2.889 0.012
ENSG00000090621 E015 45.9628415 0.1842730217 3.092997e-01 5.497849e-01 1 39561788 39562072 285 - 1.751 1.584 -0.566
ENSG00000090621 E016 1077.2051524 0.0081283610 6.195858e-01 7.835349e-01 1 39562073 39562203 131 - 2.999 3.012 0.043
ENSG00000090621 E017 688.5149357 0.0081102006 1.890051e-01 4.157103e-01 1 39562323 39562380 58 - 2.778 2.830 0.174
ENSG00000090621 E018 419.6055021 0.0056430950 1.106574e-01 3.000649e-01 1 39562381 39562383 3 - 2.560 2.618 0.190
ENSG00000090621 E019 521.1737411 0.0051232530 6.264598e-02 2.086941e-01 1 39562384 39562416 33 - 2.649 2.714 0.216
ENSG00000090621 E020 138.4137102 0.1370391208 1.145272e-01 3.066948e-01 1 39562417 39563445 1029 - 2.267 2.020 -0.828
ENSG00000090621 E021 20.8904512 0.1801289464 1.127787e-01 3.037799e-01 1 39563446 39563526 81 - 1.496 1.183 -1.091
ENSG00000090621 E022 23.3207307 0.1456620514 2.338553e-01 4.695990e-01 1 39563527 39563613 87 - 1.483 1.282 -0.699
ENSG00000090621 E023 355.6734495 0.0003869441 5.215192e-04 5.868793e-03 1 39563614 39563615 2 - 2.484 2.552 0.225
ENSG00000090621 E024 855.7835184 0.0014110351 2.674132e-05 4.885735e-04 1 39563616 39563741 126 - 2.849 2.936 0.288
ENSG00000090621 E025 63.1516381 0.0990731153 1.899322e-02 9.243935e-02 1 39563742 39563795 54 - 1.990 1.624 -1.237
ENSG00000090621 E026 69.8100681 0.1469747960 3.625315e-02 1.449360e-01 1 39563796 39563832 37 - 2.036 1.663 -1.257
ENSG00000090621 E027 60.5479398 0.0976786544 3.695507e-02 1.468028e-01 1 39563833 39563835 3 - 1.951 1.630 -1.084
ENSG00000090621 E028 737.3161455 0.0018604946 8.551815e-05 1.312275e-03 1 39563836 39563922 87 - 2.779 2.873 0.311
ENSG00000090621 E029 131.9578286 0.1610814160 1.150629e-01 3.075886e-01 1 39563923 39564232 310 - 2.250 1.996 -0.850
ENSG00000090621 E030 81.0792995 0.1294942982 1.033994e-01 2.879188e-01 1 39564233 39564384 152 - 2.045 1.783 -0.880
ENSG00000090621 E031 44.1980850 0.0981600994 4.531302e-02 1.683666e-01 1 39564385 39564422 38 - 1.814 1.499 -1.073
ENSG00000090621 E032 578.3453487 0.0015987347 2.825013e-03 2.234420e-02 1 39564423 39564470 48 - 2.691 2.760 0.230
ENSG00000090621 E033 878.3094670 0.0012815861 4.873028e-07 1.513446e-05 1 39564471 39564542 72 - 2.850 2.951 0.335
ENSG00000090621 E034 18.7059293 0.0938774044 9.628907e-01 9.834170e-01 1 39564543 39564685 143 - 1.277 1.267 -0.033
ENSG00000090621 E035 589.4143527 0.0056950016 1.597988e-03 1.431077e-02 1 39564686 39564700 15 - 2.666 2.782 0.387
ENSG00000090621 E036 997.2368398 0.0633884324 5.826138e-02 1.988609e-01 1 39564701 39564773 73 - 2.847 3.026 0.595
ENSG00000090621 E037 11.9432758 0.3084951104 9.544061e-01 9.790994e-01 1 39564774 39565001 228 - 1.108 1.078 -0.106
ENSG00000090621 E038 1577.0580180 0.0610465692 2.023338e-01 4.325776e-01 1 39565106 39565298 193 - 3.103 3.204 0.334
ENSG00000090621 E039 968.7489376 0.0031853948 6.720593e-01 8.176182e-01 1 39565299 39565366 68 - 2.977 2.954 -0.079
ENSG00000090621 E040 590.4570881 0.0009184577 1.388536e-01 3.457607e-01 1 39565367 39565378 12 - 2.773 2.733 -0.134
ENSG00000090621 E041 20.1530119 0.0790685892 6.664132e-01 8.139478e-01 1 39565379 39565395 17 - 1.351 1.274 -0.268
ENSG00000090621 E042 14.5933347 0.1020288347 2.775176e-01 5.175892e-01 1 39567357 39567373 17 - 1.284 1.094 -0.673
ENSG00000090621 E043 35.4864752 0.1418971078 1.550923e-01 3.695690e-01 1 39567374 39567750 377 - 1.685 1.438 -0.845
ENSG00000090621 E044 1168.4162667 0.0009587940 4.523773e-05 7.640385e-04 1 39567751 39567846 96 - 3.096 3.014 -0.270
ENSG00000090621 E045 90.4312515 0.1656304066 9.197479e-02 2.673737e-01 1 39567847 39568676 830 - 2.103 1.819 -0.953
ENSG00000090621 E046 14.9751501 0.2434150515 1.009824e-01 2.835694e-01 1 39568677 39568697 21 - 1.376 1.032 -1.224
ENSG00000090621 E047 29.5860170 0.1363942867 1.373718e-01 3.434932e-01 1 39568698 39568801 104 - 1.611 1.359 -0.868
ENSG00000090621 E048 870.9392852 0.0036058167 1.844325e-04 2.499871e-03 1 39568802 39568824 23 - 2.993 2.870 -0.407
ENSG00000090621 E049 941.3130342 0.0034353591 9.266320e-04 9.312206e-03 1 39568825 39568861 37 - 3.016 2.911 -0.351
ENSG00000090621 E050 1299.3711447 0.0052280963 2.792597e-03 2.214039e-02 1 39568862 39568939 78 - 3.159 3.049 -0.368
ENSG00000090621 E051 8.7008339 0.0821137073 1.298263e-01 3.315696e-01 1 39569495 39569594 100 - 1.124 0.855 -0.997
ENSG00000090621 E052 1288.2538464 0.0037630217 1.113254e-04 1.634585e-03 1 39569595 39569689 95 - 3.163 3.040 -0.409
ENSG00000090621 E053 1473.5160444 0.0007133424 3.447217e-12 3.237924e-10 1 39569863 39570002 140 - 3.218 3.101 -0.387
ENSG00000090621 E054 122.2375291 0.0473097984 3.081262e-04 3.811415e-03 1 39571097 39571233 137 - 2.295 1.879 -1.393
ENSG00000090621 E055 1210.5749218 0.0067958734 6.957801e-02 2.239099e-01 1 39571234 39571349 116 - 3.116 3.026 -0.297
ENSG00000090621 E056 2.6004304 0.0540907215 5.407357e-01 7.295431e-01 1 39571607 39571705 99 - 0.617 0.490 -0.585
ENSG00000090621 E057 1207.3357548 0.1485634976 4.774900e-01 6.853780e-01 1 39572393 39572586 194 - 3.034 3.068 0.111
ENSG00000090621 E058 18.9016589 0.2844387113 5.060080e-01 7.049312e-01 1 39572587 39575095 2509 - 1.359 1.225 -0.469
ENSG00000090621 E059 1.5273116 0.2093752767 6.624504e-01 8.114199e-01 1 39575632 39575686 55 - 0.451 0.337 -0.641
ENSG00000090621 E060 627.6525926 0.0964011882 2.518787e-01 4.899313e-01 1 39575759 39575937 179 - 2.704 2.804 0.331
ENSG00000090621 E061 622.0846954 0.0012442580 9.412063e-12 8.117749e-10 1 39575938 39576223 286 - 2.665 2.817 0.504
ENSG00000090621 E062 241.4414437 0.0006730516 9.734651e-02 2.771307e-01 1 39576224 39576233 10 - 2.335 2.371 0.119
ENSG00000090621 E063 406.6048756 0.0024081639 3.810802e-02 1.499205e-01 1 39576234 39576551 318 - 2.547 2.604 0.190
ENSG00000090621 E064 207.7571974 0.0022177632 2.478786e-05 4.582570e-04 1 39576552 39576861 310 - 2.198 2.341 0.477