ENSG00000090487

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000204566 ENSG00000090487 HEK293_OSMI2_6hA HEK293_TMG_6hB SPG21 protein_coding protein_coding 55.27735 46.92131 44.71882 5.9436 2.432511 -0.06934598 31.398440 31.214440 20.697770 3.8314270 0.5598793 -0.5925035 0.57371667 0.66583333 0.4667333 -0.19910000 7.364432e-03 4.332454e-05 FALSE TRUE
ENST00000433215 ENSG00000090487 HEK293_OSMI2_6hA HEK293_TMG_6hB SPG21 protein_coding protein_coding 55.27735 46.92131 44.71882 5.9436 2.432511 -0.06934598 17.302500 9.585069 18.735513 1.1823425 2.2131530 0.9661802 0.30372500 0.20456667 0.4160000 0.21143333 4.332454e-05 4.332454e-05 FALSE TRUE
MSTRG.11045.2 ENSG00000090487 HEK293_OSMI2_6hA HEK293_TMG_6hB SPG21 protein_coding   55.27735 46.92131 44.71882 5.9436 2.432511 -0.06934598 3.247897 3.394261 1.879811 0.7219701 0.6464126 -0.8491000 0.05894167 0.07146667 0.0421000 -0.02936667 6.237695e-01 4.332454e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000090487 E001 5.0186455 0.0052573178 2.229171e-01 4.568625e-01 15 64963022 64963026 5 - 0.860 0.697 -0.651
ENSG00000090487 E002 21.2023565 0.0019835016 4.611304e-01 6.739175e-01 15 64963027 64963055 29 - 1.303 1.359 0.197
ENSG00000090487 E003 202.4869623 0.0002507182 2.124715e-04 2.812796e-03 15 64963056 64963203 148 - 2.239 2.335 0.320
ENSG00000090487 E004 201.7795506 0.0004256073 1.577427e-04 2.192284e-03 15 64963204 64963264 61 - 2.233 2.334 0.340
ENSG00000090487 E005 165.3222676 0.0003251010 3.724775e-04 4.463080e-03 15 64963265 64963288 24 - 2.147 2.250 0.343
ENSG00000090487 E006 332.3284371 0.0031412662 6.771985e-03 4.357198e-02 15 64963289 64963393 105 - 2.456 2.554 0.327
ENSG00000090487 E007 702.4846541 0.0002219354 7.310750e-01 8.548167e-01 15 64963394 64963736 343 - 2.835 2.841 0.020
ENSG00000090487 E008 437.9039653 0.0009733018 6.138283e-02 2.058739e-01 15 64965320 64965460 141 - 2.657 2.619 -0.128
ENSG00000090487 E009 351.0771327 0.0005893357 2.879610e-02 1.237722e-01 15 64969255 64969358 104 - 2.565 2.520 -0.153
ENSG00000090487 E010 168.8226357 0.0011732466 2.777290e-02 1.206293e-01 15 64969359 64969362 4 - 2.258 2.190 -0.226
ENSG00000090487 E011 364.9770864 0.0008909371 2.858008e-01 5.264136e-01 15 64970114 64970222 109 - 2.568 2.545 -0.074
ENSG00000090487 E012 269.8436303 0.0002287154 8.590931e-02 2.562596e-01 15 64974602 64974629 28 - 2.443 2.405 -0.126
ENSG00000090487 E013 289.9860470 0.0001850604 1.107823e-02 6.269247e-02 15 64974630 64974665 36 - 2.483 2.430 -0.179
ENSG00000090487 E014 311.8231879 0.0002700930 6.402028e-02 2.117092e-01 15 64974666 64974747 82 - 2.506 2.468 -0.127
ENSG00000090487 E015 0.5117739 0.0213534553 4.287264e-01   15 64976473 64976474 2 - 0.239 0.109 -1.371
ENSG00000090487 E016 282.2161841 0.0001983232 6.670330e-02 2.176666e-01 15 64976475 64976555 81 - 2.463 2.424 -0.131
ENSG00000090487 E017 178.5191554 0.0002831246 3.212578e-01 5.607780e-01 15 64980864 64980873 10 - 2.260 2.233 -0.090
ENSG00000090487 E018 240.4805845 0.0002693035 6.184899e-01 7.827946e-01 15 64980874 64980929 56 - 2.378 2.367 -0.039
ENSG00000090487 E019 197.7629896 0.0002747431 7.382046e-01 8.593942e-01 15 64980930 64980968 39 - 2.284 2.292 0.029
ENSG00000090487 E020 197.1895685 0.0011406925 9.989845e-01 1.000000e+00 15 64980969 64981025 57 - 2.288 2.289 0.004
ENSG00000090487 E021 0.8405746 0.0180326200 4.714979e-01   15 64981026 64981627 602 - 0.322 0.195 -0.952
ENSG00000090487 E022 1.3022121 0.0136968632 2.806267e-01   15 64982933 64983180 248 - 0.239 0.432 1.215
ENSG00000090487 E023 164.3246298 0.0024527795 4.866733e-01 6.917046e-01 15 64983507 64983593 87 - 2.195 2.223 0.091
ENSG00000090487 E024 2.2022891 0.0116829948 2.080053e-01 4.394363e-01 15 64987172 64987261 90 - 0.595 0.384 -1.043
ENSG00000090487 E025 2.3914894 0.2483003476 2.680618e-01 5.077086e-01 15 64987262 64987476 215 - 0.660 0.392 -1.285
ENSG00000090487 E026 3.7581118 0.0070265208 4.255088e-01 6.476912e-01 15 64988619 64988731 113 - 0.732 0.615 -0.494
ENSG00000090487 E027 3.1325331 0.0087887556 5.811366e-01 7.578991e-01 15 64988732 64988816 85 - 0.669 0.584 -0.371
ENSG00000090487 E028 3.3561414 0.1235435352 3.317267e-01 5.705891e-01 15 64988817 64989168 352 - 0.732 0.524 -0.910
ENSG00000090487 E029 3.3333442 0.0069052056 4.396268e-01 6.583895e-01 15 64989169 64989273 105 - 0.552 0.672 0.525
ENSG00000090487 E030 5.1538177 0.0054532470 7.256148e-01 8.515264e-01 15 64989406 64989508 103 - 0.813 0.765 -0.188
ENSG00000090487 E031 1.9877883 0.0099445114 3.179365e-01 5.578865e-01 15 64989509 64989664 156 - 0.552 0.384 -0.854
ENSG00000090487 E032 142.5457216 0.0003360610 3.315972e-07 1.077758e-05 15 64989665 64989946 282 - 2.048 2.208 0.533
ENSG00000090487 E033 0.5255656 0.2465686352 5.011670e-01   15 64990090 64990310 221 - 0.239 0.110 -1.346