ENSG00000090470

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000204549 ENSG00000090470 HEK293_OSMI2_6hA HEK293_TMG_6hB PDCD7 protein_coding protein_coding 14.64289 12.875 12.96209 2.001876 2.009737 0.009717792 13.87766 12.65553 11.92053 2.033817 1.792538 -0.08624949 0.9474792 0.9809667 0.9212 -0.05976667 0.004153747 0.004153747 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000090470 E001 521.27997 1.5785104364 0.593079316 0.76572224 15 65117379 65118758 1380 - 2.671 2.739 0.226
ENSG00000090470 E002 98.13272 0.3391031018 0.362167053 0.59748007 15 65118759 65118840 82 - 1.944 2.022 0.262
ENSG00000090470 E003 3.22001 0.0950954301 0.002369877 0.01950279 15 65118964 65119375 412 - 0.846 0.324 -2.436
ENSG00000090470 E004 94.45174 0.0004475228 0.580585069 0.75755741 15 65119376 65119463 88 - 1.973 1.983 0.032
ENSG00000090470 E005 148.61371 0.0919467523 0.322511776 0.56192717 15 65119718 65119954 237 - 2.180 2.161 -0.064
ENSG00000090470 E006 125.96085 0.1100927494 0.296836902 0.53734838 15 65129032 65129170 139 - 2.123 2.078 -0.150
ENSG00000090470 E007 128.58489 0.1323939642 0.890692602 0.94702101 15 65132912 65133808 897 - 2.024 2.158 0.449