ENSG00000090372

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263280 ENSG00000090372 HEK293_OSMI2_6hA HEK293_TMG_6hB STRN4 protein_coding protein_coding 91.80356 148.458 56.25248 18.46232 1.722316 -1.399907 42.766837 68.90702 17.262725 14.565910 1.0189361 -1.996365 0.4406125 0.4530667 0.30683333 -0.14623333 0.255818899 0.004106335 TRUE TRUE
ENST00000594581 ENSG00000090372 HEK293_OSMI2_6hA HEK293_TMG_6hB STRN4 protein_coding retained_intron 91.80356 148.458 56.25248 18.46232 1.722316 -1.399907 4.639164 5.88961 4.533259 1.667467 0.1650010 -0.376892 0.0561500 0.0437000 0.08063333 0.03693333 0.435214001 0.004106335 TRUE TRUE
MSTRG.17380.8 ENSG00000090372 HEK293_OSMI2_6hA HEK293_TMG_6hB STRN4 protein_coding   91.80356 148.458 56.25248 18.46232 1.722316 -1.399907 26.170086 45.76548 22.445675 5.211292 0.5309948 -1.027495 0.2982500 0.3090667 0.39926667 0.09020000 0.004106335 0.004106335 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000090372 E001 5.2308272 0.0050724093 6.587857e-01 8.092483e-01 19 46719511 46719512 2 - 0.669 0.747 0.324
ENSG00000090372 E002 581.1733619 0.0001828030 1.513572e-03 1.370950e-02 19 46719513 46719807 295 - 2.627 2.697 0.235
ENSG00000090372 E003 933.8375477 0.0015300673 1.119481e-04 1.641316e-03 19 46719808 46720070 263 - 2.805 2.906 0.336
ENSG00000090372 E004 1007.1983694 0.0004633574 1.581471e-07 5.594046e-06 19 46720071 46720338 268 - 2.840 2.940 0.332
ENSG00000090372 E005 22.4496783 0.0157517756 1.557989e-02 8.028019e-02 19 46720339 46720408 70 - 1.056 1.335 0.992
ENSG00000090372 E006 36.0993973 0.0085173513 4.953767e-04 5.632456e-03 19 46720409 46720535 127 - 1.211 1.537 1.132
ENSG00000090372 E007 910.6407167 0.0016061822 1.362999e-01 3.418477e-01 19 46720536 46720698 163 - 2.841 2.885 0.144
ENSG00000090372 E008 679.2480091 0.0027330284 1.057856e-01 2.919685e-01 19 46720699 46720771 73 - 2.779 2.739 -0.133
ENSG00000090372 E009 79.5378282 0.0971407933 4.399005e-02 1.650506e-01 19 46720772 46721752 981 - 2.029 1.741 -0.971
ENSG00000090372 E010 684.7517051 0.0041502494 1.623041e-01 3.802156e-01 19 46721986 46722072 87 - 2.784 2.741 -0.143
ENSG00000090372 E011 28.5127628 0.0491469383 9.041988e-03 5.401307e-02 19 46722073 46722241 169 - 1.616 1.298 -1.098
ENSG00000090372 E012 762.5227363 0.0060499663 2.070994e-01 4.383239e-01 19 46722242 46722337 96 - 2.832 2.787 -0.151
ENSG00000090372 E013 408.6440705 0.0031976118 9.756028e-02 2.775299e-01 19 46722338 46722340 3 - 2.565 2.517 -0.160
ENSG00000090372 E014 505.8916075 0.0017588171 2.409019e-02 1.093518e-01 19 46722810 46722859 50 - 2.663 2.609 -0.178
ENSG00000090372 E015 579.7244904 0.0045257254 5.191767e-01 7.144678e-01 19 46722860 46722922 63 - 2.694 2.675 -0.061
ENSG00000090372 E016 405.5421041 0.0024158934 3.717844e-01 6.054733e-01 19 46722923 46722933 11 - 2.498 2.533 0.117
ENSG00000090372 E017 441.0812315 0.0016660156 2.855470e-01 5.261425e-01 19 46722934 46722950 17 - 2.532 2.570 0.127
ENSG00000090372 E018 15.6252266 0.2606206366 4.443489e-01 6.616512e-01 19 46722951 46723113 163 - 1.192 1.125 -0.240
ENSG00000090372 E019 727.6503110 0.0001525348 9.503830e-02 2.730265e-01 19 46723114 46723284 171 - 2.752 2.790 0.127
ENSG00000090372 E020 317.3203389 0.0001733699 5.396819e-01 7.287607e-01 19 46724807 46724827 21 - 2.403 2.428 0.086
ENSG00000090372 E021 625.9253266 0.0014201491 7.209049e-01 8.487440e-01 19 46724828 46724928 101 - 2.698 2.717 0.063
ENSG00000090372 E022 350.2473153 0.0007695747 4.185165e-01 6.425266e-01 19 46725332 46725332 1 - 2.471 2.460 -0.037
ENSG00000090372 E023 610.8841933 0.0001206842 1.126685e-01 3.036139e-01 19 46725333 46725379 47 - 2.719 2.701 -0.059
ENSG00000090372 E024 465.0626082 0.0001192669 7.419184e-02 2.331260e-01 19 46725473 46725480 8 - 2.607 2.582 -0.084
ENSG00000090372 E025 919.4448636 0.0003617200 1.860676e-01 4.119223e-01 19 46725481 46725632 152 - 2.891 2.879 -0.040
ENSG00000090372 E026 428.9203260 0.0026781597 2.551677e-01 4.937707e-01 19 46725633 46725648 16 - 2.569 2.543 -0.085
ENSG00000090372 E027 104.8703574 0.1187770802 1.398618e-02 7.429385e-02 19 46725649 46726265 617 - 2.209 1.823 -1.296
ENSG00000090372 E028 347.0362606 0.0034316806 1.379979e-01 3.444583e-01 19 46727452 46727452 1 - 2.490 2.448 -0.140
ENSG00000090372 E029 663.7468031 0.0007737414 3.776016e-02 1.489869e-01 19 46727453 46727546 94 - 2.766 2.733 -0.111
ENSG00000090372 E030 78.7609660 0.0005755656 1.372667e-01 3.433359e-01 19 46727547 46727567 21 - 1.868 1.808 -0.201
ENSG00000090372 E031 29.7139871 0.0954226008 9.338224e-03 5.525658e-02 19 46727568 46727691 124 - 1.695 1.275 -1.445
ENSG00000090372 E032 353.9107478 0.0014010249 7.480089e-01 8.655273e-01 19 46727894 46727906 13 - 2.468 2.467 -0.004
ENSG00000090372 E033 612.0792941 0.0258540480 4.418551e-01 6.599922e-01 19 46727907 46728007 101 - 2.663 2.712 0.165
ENSG00000090372 E034 9.1886862 0.0037524550 9.518810e-01 9.779031e-01 19 46728008 46728126 119 - 0.921 0.937 0.063
ENSG00000090372 E035 0.3447487 0.6502106564 1.000000e+00   19 46728127 46728299 173 - 0.001 0.130 7.812
ENSG00000090372 E036 0.8738308 0.0741908578 8.333938e-01   19 46728300 46728406 107 - 0.208 0.264 0.450
ENSG00000090372 E037 530.2500201 1.4403738675 5.019440e-01 7.021513e-01 19 46728618 46728684 67 - 2.498 2.671 0.574
ENSG00000090372 E038 329.3803146 1.2859873810 4.976060e-01 6.992147e-01 19 46728685 46728686 2 - 2.307 2.462 0.516
ENSG00000090372 E039 580.3250944 1.4891485815 5.341408e-01 7.250082e-01 19 46728687 46728777 91 - 2.560 2.706 0.484
ENSG00000090372 E040 293.6398618 0.8859637598 4.536670e-01 6.684303e-01 19 46730732 46730732 1 - 2.269 2.410 0.470
ENSG00000090372 E041 599.9886351 0.0390803676 3.116353e-01 5.519983e-01 19 46730733 46730835 103 - 2.631 2.709 0.259
ENSG00000090372 E042 470.1608792 0.0013257739 2.657761e-01 5.052308e-01 19 46730836 46730873 38 - 2.562 2.596 0.113
ENSG00000090372 E043 1.0414035 0.0157096950 6.563016e-01   19 46730874 46730931 58 - 0.347 0.267 -0.525
ENSG00000090372 E044 1.1707238 0.5551979110 8.801112e-01   19 46731468 46731788 321 - 0.210 0.309 0.734
ENSG00000090372 E045 464.8580810 0.0001779355 5.358415e-01 7.262166e-01 19 46733039 46733074 36 - 2.568 2.590 0.075
ENSG00000090372 E046 446.9524839 0.0001347992 6.102133e-01 7.770506e-01 19 46733075 46733109 35 - 2.570 2.570 -0.001
ENSG00000090372 E047 686.8239012 0.0008570859 2.544223e-01 4.929128e-01 19 46733110 46733199 90 - 2.766 2.750 -0.051
ENSG00000090372 E048 517.2094737 0.0016562257 5.350164e-02 1.878864e-01 19 46733200 46733236 37 - 2.664 2.621 -0.144
ENSG00000090372 E049 3.8792971 0.0877849479 2.820927e-01 5.224532e-01 19 46733237 46733449 213 - 0.770 0.572 -0.839
ENSG00000090372 E050 4.8499320 0.0796865235 3.924415e-01 6.223267e-01 19 46733816 46733875 60 - 0.813 0.661 -0.619
ENSG00000090372 E051 1.7845360 0.2563694883 8.819272e-01 9.423349e-01 19 46736150 46736204 55 - 0.351 0.383 0.190
ENSG00000090372 E052 2.4048127 0.0326709064 4.983710e-01 6.997080e-01 19 46736205 46736268 64 - 0.347 0.485 0.749
ENSG00000090372 E053 1.5790253 0.1499951801 9.802188e-01 9.919203e-01 19 46736269 46736349 81 - 0.347 0.347 0.000
ENSG00000090372 E054 617.6303807 0.0001659582 6.885905e-03 4.411941e-02 19 46736823 46736901 79 - 2.739 2.701 -0.125
ENSG00000090372 E055 610.8414592 0.0001200340 4.569898e-06 1.065011e-04 19 46738164 46738237 74 - 2.758 2.690 -0.228
ENSG00000090372 E056 508.8029974 0.0002836098 2.476338e-05 4.578543e-04 19 46738785 46738888 104 - 2.682 2.609 -0.242
ENSG00000090372 E057 2.5870482 0.0691348192 3.960050e-01 6.251929e-01 19 46739310 46739386 77 - 0.347 0.529 0.963
ENSG00000090372 E058 2.9393296 0.1777586932 4.003914e-01 6.286175e-01 19 46739387 46739507 121 - 0.668 0.500 -0.760
ENSG00000090372 E059 5.8416994 0.0648256180 3.476273e-01 5.850447e-01 19 46740164 46740285 122 - 0.886 0.723 -0.644
ENSG00000090372 E060 2.4245326 0.8037179771 9.072976e-01 9.557614e-01 19 46745757 46745830 74 - 0.556 0.443 -0.550
ENSG00000090372 E061 262.6949754 0.0049087466 1.430769e-01 3.521157e-01 19 46746149 46746211 63 - 2.376 2.325 -0.167
ENSG00000090372 E062 144.5450496 0.0077191902 7.249524e-02 2.297808e-01 19 46746212 46746763 552 - 1.986 2.100 0.382
ENSG00000090372 E063 4.6885366 0.1565504959 1.725523e-01 3.938623e-01 19 46746764 46746801 38 - 0.895 0.614 -1.140
ENSG00000090372 E064 1.1987712 1.0366022508 2.204678e-01   19 46746802 46747475 674 - 0.695 0.065 -4.616