ENSG00000090061

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000389879 ENSG00000090061 HEK293_OSMI2_6hA HEK293_TMG_6hB CCNK protein_coding protein_coding 46.83276 59.35092 49.19758 11.22677 1.544044 -0.2706329 23.30619 31.16001 19.92979 6.361734 0.7863337 -0.6445084 0.4957958 0.5210000 0.4049000 -0.11610000 0.003027962 0.003027962 FALSE TRUE
ENST00000557441 ENSG00000090061 HEK293_OSMI2_6hA HEK293_TMG_6hB CCNK protein_coding protein_coding 46.83276 59.35092 49.19758 11.22677 1.544044 -0.2706329 17.03028 22.76095 20.03530 4.528465 0.4876474 -0.1839306 0.3623708 0.3816667 0.4074333 0.02576667 0.745285883 0.003027962 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000090061 E001 2.2529709 0.919663114 0.8279986791 0.912627856 14 99480991 99481164 174 + 0.506 0.498 -0.039
ENSG00000090061 E002 0.5233527 0.031542334 0.2385723273   14 99481169 99481242 74 + 0.261 0.098 -1.704
ENSG00000090061 E003 6.9369983 0.177221451 0.5839165738 0.759562966 14 99481338 99481408 71 + 0.883 0.885 0.006
ENSG00000090061 E004 6.0042853 0.109176151 0.6808901135 0.823217680 14 99481409 99481411 3 + 0.804 0.840 0.142
ENSG00000090061 E005 33.2730316 0.101263020 0.0451782754 0.168057089 14 99481412 99481423 12 + 1.629 1.442 -0.639
ENSG00000090061 E006 33.5653155 0.098518249 0.0415467527 0.158762796 14 99481424 99481424 1 + 1.633 1.446 -0.642
ENSG00000090061 E007 154.0193284 0.067666439 0.2482026461 0.486028941 14 99481425 99481449 25 + 2.172 2.179 0.022
ENSG00000090061 E008 212.4279333 0.066079869 0.3513959358 0.588552582 14 99481450 99481479 30 + 2.288 2.331 0.141
ENSG00000090061 E009 58.6896260 0.043617131 0.5023843257 0.702429744 14 99481480 99481614 135 + 1.722 1.786 0.217
ENSG00000090061 E010 6.3638938 0.086077922 0.1444577077 0.354087457 14 99491946 99492320 375 + 0.926 0.790 -0.527
ENSG00000090061 E011 577.0812194 0.124126986 0.2987261274 0.539187849 14 99492626 99492874 249 + 2.744 2.750 0.020
ENSG00000090061 E012 1.5438343 0.013696863 0.0002320677 0.003023906 14 99492875 99493103 229 + 0.673 0.098 -3.878
ENSG00000090061 E013 355.7577605 0.075457883 0.2761792513 0.516190783 14 99493514 99493595 82 + 2.525 2.546 0.068
ENSG00000090061 E014 3.5050690 0.021135266 0.0482121844 0.175492469 14 99493970 99495497 1528 + 0.774 0.546 -0.974
ENSG00000090061 E015 223.0575286 0.050523592 0.2208400147 0.454479932 14 99495498 99495504 7 + 2.323 2.344 0.072
ENSG00000090061 E016 426.5485141 0.001919273 0.0010556303 0.010334965 14 99495505 99495629 125 + 2.609 2.625 0.053
ENSG00000090061 E017 400.8565553 1.244958837 0.5721263884 0.751792829 14 99500766 99500871 106 + 2.532 2.621 0.295
ENSG00000090061 E018 15.0858291 0.459543882 0.3269557159 0.566103878 14 99500872 99501355 484 + 1.386 1.020 -1.298
ENSG00000090061 E019 304.4441032 1.127184755 0.5407438684 0.729543065 14 99501356 99501413 58 + 2.406 2.506 0.333
ENSG00000090061 E020 18.2348129 0.389454011 0.3964450944 0.625492356 14 99501414 99502206 793 + 1.450 1.116 -1.170
ENSG00000090061 E021 413.0534942 1.209789788 0.4812048768 0.687899828 14 99502207 99502376 170 + 2.496 2.656 0.535
ENSG00000090061 E022 392.9653683 1.167754772 0.4375815215 0.656921971 14 99502719 99502984 266 + 2.449 2.645 0.651
ENSG00000090061 E023 6.1259726 0.177884218 0.9365533319 0.970498517 14 99502985 99503610 626 + 0.797 0.868 0.278
ENSG00000090061 E024 140.7640815 0.546597017 0.3466780391 0.584271553 14 99503611 99503644 34 + 2.022 2.194 0.576
ENSG00000090061 E025 177.5690897 0.885987003 0.4025852943 0.630447442 14 99507076 99507147 72 + 2.106 2.301 0.652
ENSG00000090061 E026 1125.2603237 1.552012180 0.4390019540 0.657976002 14 99510157 99512440 2284 + 2.872 3.113 0.799
ENSG00000090061 E027 1.3885215 1.374524442 0.1192216835 0.314575185 14 99534664 99535044 381 + 0.656 0.000 -12.175