ENSG00000090060

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000216277 ENSG00000090060 HEK293_OSMI2_6hA HEK293_TMG_6hB PAPOLA protein_coding protein_coding 50.67236 17.28046 95.95093 3.431612 3.507531 2.472471 26.139464 8.5956100 47.473987 1.8671451 1.5147112 2.46409169 0.48280417 0.50783333 0.49496667 -0.01286667 0.9915498385 0.0009616838 FALSE TRUE
ENST00000392990 ENSG00000090060 HEK293_OSMI2_6hA HEK293_TMG_6hB PAPOLA protein_coding protein_coding 50.67236 17.28046 95.95093 3.431612 3.507531 2.472471 9.736448 2.2392434 22.119458 1.0635381 1.1314793 3.29845638 0.15322083 0.12283333 0.23030000 0.10746667 0.3480803432 0.0009616838 FALSE TRUE
ENST00000556459 ENSG00000090060 HEK293_OSMI2_6hA HEK293_TMG_6hB PAPOLA protein_coding protein_coding 50.67236 17.28046 95.95093 3.431612 3.507531 2.472471 4.559349 2.1434451 8.706804 1.1596738 0.5314813 2.01715269 0.12544583 0.10320000 0.09086667 -0.01233333 0.9559191196 0.0009616838 FALSE TRUE
ENST00000557471 ENSG00000090060 HEK293_OSMI2_6hA HEK293_TMG_6hB PAPOLA protein_coding protein_coding 50.67236 17.28046 95.95093 3.431612 3.507531 2.472471 1.145571 1.2747657 1.246545 0.1804182 0.4392431 -0.03204268 0.03728750 0.07876667 0.01283333 -0.06593333 0.0009616838 0.0009616838 FALSE TRUE
MSTRG.10155.9 ENSG00000090060 HEK293_OSMI2_6hA HEK293_TMG_6hB PAPOLA protein_coding   50.67236 17.28046 95.95093 3.431612 3.507531 2.472471 3.038663 0.2808431 7.898366 0.2808431 0.4778833 4.76506681 0.04058333 0.02693333 0.08220000 0.05526667 0.2950418117 0.0009616838 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000090060 E001 0.0000000       14 96500742 96501432 691 +      
ENSG00000090060 E002 0.0000000       14 96501433 96501589 157 +      
ENSG00000090060 E003 0.6190593 0.0240628616 6.577548e-01   14 96501590 96502375 786 + 0.153 0.240 0.810
ENSG00000090060 E004 0.3503582 0.0471534301 2.429187e-01   14 96502376 96502381 6 + 0.057 0.241 2.391
ENSG00000090060 E005 2.2903111 0.0983756635 6.987240e-01 8.347919e-01 14 96502382 96502397 16 + 0.411 0.504 0.480
ENSG00000090060 E006 4.8984642 0.0920088603 7.337770e-01 8.564966e-01 14 96502398 96502400 3 + 0.648 0.730 0.344
ENSG00000090060 E007 7.6614280 0.1054509467 2.203307e-01 4.539302e-01 14 96502401 96502411 11 + 0.771 1.018 0.941
ENSG00000090060 E008 26.6353586 0.0494499979 1.903690e-01 4.174290e-01 14 96502412 96502440 29 + 1.276 1.498 0.772
ENSG00000090060 E009 74.1352435 0.0200547483 3.006883e-02 1.275383e-01 14 96502441 96502541 101 + 1.707 1.914 0.698
ENSG00000090060 E010 66.6508654 0.0233024634 1.765970e-02 8.785879e-02 14 96502542 96502557 16 + 1.655 1.890 0.794
ENSG00000090060 E011 142.3986822 0.0048546722 1.000321e-04 1.495270e-03 14 96502558 96502600 43 + 1.985 2.192 0.696
ENSG00000090060 E012 0.1426347 0.0325372724 1.000000e+00   14 96502851 96502954 104 + 0.057 0.000 -14.719
ENSG00000090060 E013 0.6182515 0.0725444502 1.298537e-02   14 96504289 96504699 411 + 0.057 0.507 3.979
ENSG00000090060 E014 398.2556533 0.0018550763 2.735865e-05 4.979240e-04 14 96520055 96520228 174 + 2.443 2.589 0.487
ENSG00000090060 E015 0.6294705 0.0258112703 6.682734e-01   14 96520964 96521005 42 + 0.153 0.240 0.803
ENSG00000090060 E016 234.0517788 0.0012826998 1.305209e-02 7.065585e-02 14 96521006 96521015 10 + 2.221 2.327 0.353
ENSG00000090060 E017 309.3829530 0.0002246706 1.004009e-02 5.833177e-02 14 96521016 96521062 47 + 2.346 2.437 0.305
ENSG00000090060 E018 211.5095323 0.0002323633 2.871904e-01 5.279593e-01 14 96521063 96521072 10 + 2.189 2.248 0.195
ENSG00000090060 E019 332.2177525 0.0001674045 5.326954e-02 1.873898e-01 14 96525310 96525391 82 + 2.381 2.454 0.244
ENSG00000090060 E020 1.4810038 0.0129488987 5.542777e-02 1.923043e-01 14 96525981 96527429 1449 + 0.232 0.598 2.071
ENSG00000090060 E021 212.0558491 0.0002544819 2.008053e-01 4.307249e-01 14 96527430 96527441 12 + 2.188 2.253 0.217
ENSG00000090060 E022 387.3141720 0.0003397931 7.802523e-03 4.839650e-02 14 96527442 96527539 98 + 2.445 2.532 0.292
ENSG00000090060 E023 2.4440760 0.6625272714 7.390969e-01 8.598428e-01 14 96527540 96527952 413 + 0.407 0.608 0.979
ENSG00000090060 E024 325.9102093 0.0026053479 8.916551e-03 5.344801e-02 14 96527953 96528006 54 + 2.365 2.473 0.361
ENSG00000090060 E025 358.3962228 0.0003532775 1.350365e-07 4.874027e-06 14 96531475 96531586 112 + 2.397 2.548 0.505
ENSG00000090060 E026 22.9542204 0.0139927590 3.893547e-08 1.594439e-06 14 96531587 96532248 662 + 1.111 1.638 1.832
ENSG00000090060 E027 319.6349000 0.0002567912 4.536491e-02 1.684893e-01 14 96532331 96532420 90 + 2.364 2.441 0.255
ENSG00000090060 E028 332.4532438 0.0002665387 5.007317e-01 7.012824e-01 14 96532511 96532649 139 + 2.388 2.430 0.141
ENSG00000090060 E029 30.3467705 0.0012103568 2.723579e-01 5.122347e-01 14 96532650 96534222 1573 + 1.353 1.463 0.381
ENSG00000090060 E030 8.4738425 0.0035464187 7.419488e-01 8.616274e-01 14 96534223 96534490 268 + 0.866 0.839 -0.101
ENSG00000090060 E031 207.2456871 0.0003880981 8.013381e-06 1.732472e-04 14 96534491 96534563 73 + 2.210 2.074 -0.455
ENSG00000090060 E032 11.3882050 0.0027964430 6.829080e-04 7.294848e-03 14 96534564 96534889 326 + 0.882 1.273 1.421
ENSG00000090060 E033 5.9491343 0.0051823184 5.965899e-01 7.680384e-01 14 96535525 96535878 354 + 0.741 0.672 -0.285
ENSG00000090060 E034 276.0966764 0.0007380868 8.012223e-07 2.342331e-05 14 96535879 96535999 121 + 2.334 2.197 -0.459
ENSG00000090060 E035 1.4570612 0.0123044071 6.479302e-01 8.021769e-01 14 96536895 96536975 81 + 0.328 0.240 -0.608
ENSG00000090060 E036 252.0010417 0.0002124160 3.427827e-07 1.109864e-05 14 96536976 96537060 85 + 2.294 2.155 -0.467
ENSG00000090060 E037 21.7081757 0.0396550051 8.819327e-01 9.423349e-01 14 96537061 96537901 841 + 1.224 1.253 0.100
ENSG00000090060 E038 3.2732830 0.0075090971 8.366644e-01 9.176356e-01 14 96541907 96542181 275 + 0.531 0.508 -0.108
ENSG00000090060 E039 2.1875739 0.0922710608 5.610305e-01 7.440367e-01 14 96542182 96542242 61 + 0.382 0.512 0.673
ENSG00000090060 E040 200.6955283 0.0003559550 2.088268e-05 3.962414e-04 14 96542243 96542296 54 + 2.193 2.063 -0.437
ENSG00000090060 E041 4.3813910 0.0058819848 8.091556e-01 9.016799e-01 14 96542297 96542728 432 + 0.613 0.672 0.255
ENSG00000090060 E042 0.5963342 0.0219316139 6.658709e-01   14 96542729 96542773 45 + 0.153 0.240 0.805
ENSG00000090060 E043 262.3090040 0.0010197042 1.424283e-03 1.307014e-02 14 96542774 96542893 120 + 2.302 2.217 -0.281
ENSG00000090060 E044 280.5498605 0.0002929064 2.778066e-06 6.954296e-05 14 96544149 96544258 110 + 2.335 2.216 -0.400
ENSG00000090060 E045 0.6434498 0.0195156151 5.615767e-01   14 96547688 96547796 109 + 0.194 0.000 -16.682
ENSG00000090060 E046 313.1082648 0.0001821720 2.657225e-09 1.418158e-07 14 96547797 96547895 99 + 2.387 2.238 -0.497
ENSG00000090060 E047 193.6962695 0.0006942032 2.608413e-08 1.114667e-06 14 96547896 96547918 23 + 2.185 1.990 -0.654
ENSG00000090060 E048 420.7445747 0.0005049506 3.856681e-10 2.416801e-08 14 96552480 96552622 143 + 2.515 2.371 -0.479
ENSG00000090060 E049 2.9711558 0.0078292671 1.305456e-01 3.326678e-01 14 96552623 96553532 910 + 0.548 0.240 -1.778
ENSG00000090060 E050 173.4505342 0.0005946920 2.553891e-06 6.453157e-05 14 96555847 96555849 3 + 2.136 1.970 -0.556
ENSG00000090060 E051 361.7669341 0.0001593247 1.460000e-09 8.270233e-08 14 96555850 96555947 98 + 2.450 2.312 -0.461
ENSG00000090060 E052 0.6622309 0.1982050551 6.262536e-01   14 96555948 96555950 3 + 0.195 0.000 -16.437
ENSG00000090060 E053 556.2179120 0.0001196271 1.335949e-09 7.615804e-08 14 96556175 96556413 239 + 2.632 2.528 -0.346
ENSG00000090060 E054 2.3439437 0.0454947221 2.862044e-01 5.268799e-01 14 96560438 96560648 211 + 0.382 0.600 1.076
ENSG00000090060 E055 176.2929963 0.0010752222 9.297243e-01 9.668568e-01 14 96560649 96560711 63 + 2.118 2.138 0.068
ENSG00000090060 E056 7.4896217 0.0041317292 4.342329e-01 6.544321e-01 14 96562458 96562818 361 + 0.793 0.924 0.503
ENSG00000090060 E057 223.7083655 0.0012937117 5.492177e-01 7.357933e-01 14 96562819 96562893 75 + 2.216 2.260 0.147
ENSG00000090060 E058 2469.3212104 0.0054519712 1.367010e-01 3.424543e-01 14 96564955 96567116 2162 + 3.249 3.319 0.232