ENSG00000090054

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262554 ENSG00000090054 HEK293_OSMI2_6hA HEK293_TMG_6hB SPTLC1 protein_coding protein_coding 37.96354 8.685032 67.92348 0.9299395 1.221521 2.965859 31.727074 6.3089325 61.787362 1.2220227 0.7988650 3.289792 0.7727333 0.7113333 0.9098333 0.19850000 0.033120041 0.0001189168 FALSE TRUE
ENST00000337841 ENSG00000090054 HEK293_OSMI2_6hA HEK293_TMG_6hB SPTLC1 protein_coding protein_coding 37.96354 8.685032 67.92348 0.9299395 1.221521 2.965859 2.558456 0.9068783 2.195603 0.1409171 0.2023829 1.266371 0.0934625 0.1063667 0.0323000 -0.07406667 0.001640046 0.0001189168 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000090054 E001 0.0000000       9 92000087 92000246 160 -      
ENSG00000090054 E002 0.1308682 0.0326491905 4.726779e-02   9 92000499 92000712 214 - 0.000 0.273 12.181
ENSG00000090054 E003 0.5008152 0.0380757051 1.000000e+00   9 92000942 92001301 360 - 0.133 0.000 -12.713
ENSG00000090054 E004 0.0000000       9 92001302 92001406 105 -      
ENSG00000090054 E005 0.6847684 0.0187007034 4.662997e-01   9 92028458 92028639 182 - 0.133 0.273 1.297
ENSG00000090054 E006 0.4986023 0.0322087803 1.000000e+00   9 92028640 92028737 98 - 0.133 0.000 -12.778
ENSG00000090054 E007 0.1426347 0.0320393329 7.797421e-01   9 92028738 92028757 20 - 0.049 0.000 -11.203
ENSG00000090054 E008 0.4632531 0.0251358157 1.000000e+00   9 92029180 92029249 70 - 0.132 0.000 -12.870
ENSG00000090054 E009 0.6412370 0.0251227515 1.000000e+00   9 92029250 92029346 97 - 0.169 0.000 -13.281
ENSG00000090054 E010 0.5775531 0.0206621448 4.683842e-01   9 92031143 92031145 3 - 0.132 0.273 1.295
ENSG00000090054 E011 0.7555370 0.0174173891 6.188184e-01   9 92031146 92031146 1 - 0.169 0.273 0.879
ENSG00000090054 E012 4.2570600 0.0061609422 7.182494e-01 8.471325e-01 9 92031147 92031157 11 - 0.572 0.653 0.355
ENSG00000090054 E013 4.4350439 0.0058262209 7.739963e-01 8.811465e-01 9 92031158 92031159 2 - 0.586 0.653 0.294
ENSG00000090054 E014 4.6377781 0.0056495180 4.598126e-01 6.729993e-01 9 92031160 92031167 8 - 0.586 0.730 0.616
ENSG00000090054 E015 86.9100991 0.0005775131 8.883483e-07 2.562629e-05 9 92031168 92031271 104 - 1.723 1.984 0.879
ENSG00000090054 E016 368.2409240 0.0027875488 3.358663e-05 5.943916e-04 9 92031272 92031714 443 - 2.362 2.520 0.528
ENSG00000090054 E017 197.1496494 0.0196032698 4.109107e-01 6.367385e-01 9 92031715 92031842 128 - 2.104 2.176 0.241
ENSG00000090054 E018 571.9542518 0.0001679337 1.103228e-01 2.995423e-01 9 92031843 92032353 511 - 2.576 2.558 -0.058
ENSG00000090054 E019 375.2923879 0.0004129573 4.908843e-03 3.414296e-02 9 92032354 92032558 205 - 2.400 2.337 -0.212
ENSG00000090054 E020 50.0354171 0.0378412218 8.083375e-06 1.744938e-04 9 92032559 92033795 1237 - 1.425 1.930 1.713
ENSG00000090054 E021 7.8588064 0.0137624529 1.225835e-03 1.162080e-02 9 92033796 92033839 44 - 0.693 1.151 1.739
ENSG00000090054 E022 18.2367295 0.1250515371 1.071271e-01 2.942080e-01 9 92033840 92034066 227 - 1.047 1.403 1.260
ENSG00000090054 E023 34.6958996 0.0602112249 3.989568e-02 1.544374e-01 9 92034067 92034809 743 - 1.323 1.634 1.071
ENSG00000090054 E024 211.7295124 0.0004648963 2.215581e-02 1.031192e-01 9 92034810 92034883 74 - 2.155 2.085 -0.234
ENSG00000090054 E025 246.2949419 0.0002300712 1.007235e-01 2.830997e-01 9 92038248 92038365 118 - 2.216 2.178 -0.128
ENSG00000090054 E026 1.3086294 0.0128907675 7.353471e-02   9 92038366 92038458 93 - 0.203 0.560 2.144
ENSG00000090054 E027 191.8779221 0.0003208317 4.346965e-01 6.547682e-01 9 92045999 92046053 55 - 2.104 2.092 -0.040
ENSG00000090054 E028 3.5166632 0.0078488227 6.596103e-02 2.160632e-01 9 92046275 92046334 60 - 0.463 0.796 1.462
ENSG00000090054 E029 236.0003553 0.0021254479 2.300718e-01 4.652152e-01 9 92047172 92047268 97 - 2.194 2.162 -0.107
ENSG00000090054 E030 4.8294474 0.0068921387 6.907906e-01 8.295710e-01 9 92047269 92047612 344 - 0.624 0.560 -0.288
ENSG00000090054 E031 212.7512302 0.0005028605 6.308555e-03 4.124178e-02 9 92047613 92047708 96 - 2.155 2.066 -0.298
ENSG00000090054 E032 206.4254532 0.0002755620 5.670937e-02 1.953143e-01 9 92049960 92050067 108 - 2.141 2.086 -0.184
ENSG00000090054 E033 2.5678755 0.4801743166 6.426846e-01 7.986611e-01 9 92050296 92050491 196 - 0.397 0.567 0.848
ENSG00000090054 E034 206.4055601 0.0016466642 4.361528e-01 6.559202e-01 9 92055405 92055494 90 - 2.137 2.121 -0.052
ENSG00000090054 E035 267.1997448 0.0012263081 9.081963e-02 2.652506e-01 9 92059179 92059308 130 - 2.252 2.207 -0.150
ENSG00000090054 E036 267.1283102 0.0013595695 2.247434e-03 1.871371e-02 9 92067966 92068098 133 - 2.258 2.159 -0.329
ENSG00000090054 E037 2.0031161 0.3924021522 4.329956e-02 1.633368e-01 9 92070124 92070296 173 - 0.206 0.859 3.359
ENSG00000090054 E038 1.8149814 0.3271584215 2.185259e-01 4.516799e-01 9 92070344 92070403 60 - 0.264 0.661 2.101
ENSG00000090054 E039 4.8078670 0.0072412089 3.817314e-02 1.500452e-01 9 92076798 92077035 238 - 0.558 0.903 1.422
ENSG00000090054 E040 8.9698316 0.0038448653 3.143449e-09 1.647624e-07 9 92079061 92079433 373 - 0.660 1.360 2.619
ENSG00000090054 E041 12.9417757 0.0378398301 6.549574e-03 4.245750e-02 9 92079434 92079566 133 - 0.904 1.291 1.405
ENSG00000090054 E042 0.0000000       9 92079853 92080015 163 -      
ENSG00000090054 E043 214.2230266 0.0005561291 5.811598e-02 1.985570e-01 9 92080016 92080084 69 - 2.158 2.104 -0.182
ENSG00000090054 E044 130.0734674 0.0004612591 5.699853e-01 7.502755e-01 9 92080085 92080088 4 - 1.938 1.929 -0.029
ENSG00000090054 E045 224.4842252 0.0002039949 1.608478e-01 3.780190e-01 9 92080870 92080963 94 - 2.174 2.141 -0.109
ENSG00000090054 E046 0.0000000       9 92102805 92102939 135 -      
ENSG00000090054 E047 0.0000000       9 92103190 92103415 226 -      
ENSG00000090054 E048 0.1723744 0.0374470057 4.693873e-02   9 92103936 92103998 63 - 0.000 0.273 13.849
ENSG00000090054 E049 0.3150090 0.0286019280 1.559904e-01   9 92103999 92104030 32 - 0.049 0.273 2.883
ENSG00000090054 E050 14.0501652 0.0305873048 6.910778e-11 5.052127e-09 9 92107176 92108069 894 - 0.787 1.583 2.867
ENSG00000090054 E051 2.0664967 0.3134806095 3.158044e-01 5.558004e-01 9 92108070 92108739 670 - 0.323 0.569 1.298
ENSG00000090054 E052 202.7534263 0.0005291932 5.624339e-01 7.450174e-01 9 92108740 92108834 95 - 2.126 2.122 -0.015
ENSG00000090054 E053 163.5696022 0.0030700420 4.086648e-01 6.349965e-01 9 92112455 92112562 108 - 2.036 2.014 -0.075
ENSG00000090054 E054 2.3861402 0.0484789987 4.064900e-01 6.334081e-01 9 92114922 92115066 145 - 0.383 0.561 0.898
ENSG00000090054 E055 0.6002783 0.4982720827 4.294384e-01   9 92115067 92115313 247 - 0.128 0.275 1.363
ENSG00000090054 E056 91.7640910 0.0105605805 6.033458e-01 7.724411e-01 9 92115314 92115413 100 - 1.779 1.833 0.183