ENSG00000089902

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262241 ENSG00000089902 HEK293_OSMI2_6hA HEK293_TMG_6hB RCOR1 protein_coding protein_coding 12.70924 9.516932 16.55609 1.77092 0.9813929 0.7981499 8.9798819 8.8991122 8.943463 1.7131645 0.5140403 0.007164166 0.75979583 0.93363333 0.5404333 -0.3932 6.842334e-08 1.042655e-25 FALSE TRUE
ENST00000560472 ENSG00000089902 HEK293_OSMI2_6hA HEK293_TMG_6hB RCOR1 protein_coding nonsense_mediated_decay 12.70924 9.516932 16.55609 1.77092 0.9813929 0.7981499 0.7681985 0.2912008 2.435096 0.1798711 0.2396492 3.021093652 0.04990417 0.03316667 0.1463667 0.1132 2.857174e-01 1.042655e-25 FALSE FALSE
MSTRG.10204.3 ENSG00000089902 HEK293_OSMI2_6hA HEK293_TMG_6hB RCOR1 protein_coding   12.70924 9.516932 16.55609 1.77092 0.9813929 0.7981499 2.2093699 0.0000000 4.440577 0.0000000 0.3936329 8.797848600 0.12959583 0.00000000 0.2674000 0.2674 1.042655e-25 1.042655e-25 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000089902 E001 10.3241382 0.0033351212 1.669301e-01 3.864470e-01 14 102592649 102593016 368 + 0.979 1.124 0.531
ENSG00000089902 E002 6.0802357 0.0070581563 6.238773e-02 2.081262e-01 14 102593017 102593043 27 + 0.721 0.963 0.942
ENSG00000089902 E003 29.6782841 0.0023564335 8.637379e-01 9.324723e-01 14 102593044 102593187 144 + 1.493 1.487 -0.021
ENSG00000089902 E004 38.8275111 0.0011004964 9.373488e-02 2.707089e-01 14 102593266 102593325 60 + 1.645 1.554 -0.310
ENSG00000089902 E005 57.4558642 0.0006728228 1.001894e-02 5.823682e-02 14 102681895 102681978 84 + 1.820 1.704 -0.394
ENSG00000089902 E006 56.6598165 0.0006745100 5.688640e-03 3.818427e-02 14 102701278 102701330 53 + 1.818 1.692 -0.427
ENSG00000089902 E007 93.0684880 0.0004836621 4.513439e-04 5.234843e-03 14 102707351 102707512 162 + 2.030 1.905 -0.421
ENSG00000089902 E008 99.4210858 0.0004247995 2.047049e-02 9.756832e-02 14 102708465 102708583 119 + 2.036 1.957 -0.265
ENSG00000089902 E009 0.4054685 0.4156755836 2.651674e-01   14 102710742 102710934 193 + 0.000 0.235 10.381
ENSG00000089902 E010 87.0018645 0.0005701115 5.694492e-03 3.820844e-02 14 102710935 102711013 79 + 1.988 1.884 -0.347
ENSG00000089902 E011 116.3729652 0.0019399340 9.050426e-03 5.404636e-02 14 102714423 102714617 195 + 2.114 2.016 -0.327
ENSG00000089902 E012 0.1308682 0.0326491905 4.378545e-01   14 102720926 102721006 81 + 0.000 0.128 10.202
ENSG00000089902 E013 48.4271950 0.0021625337 2.334402e-01 4.690986e-01 14 102721007 102721021 15 + 1.720 1.658 -0.211
ENSG00000089902 E014 69.0236437 0.0008637314 5.937665e-02 2.014013e-01 14 102721022 102721084 63 + 1.880 1.801 -0.266
ENSG00000089902 E015 62.3253724 0.0006072425 2.121130e-02 1.000185e-01 14 102721320 102721377 58 + 1.844 1.743 -0.338
ENSG00000089902 E016 1.7493450 0.0106866378 4.695604e-02 1.724565e-01 14 102721378 102721551 174 + 0.573 0.226 -2.002
ENSG00000089902 E017 120.0758551 0.0018934127 5.741223e-02 1.969800e-01 14 102722187 102722416 230 + 2.111 2.043 -0.225
ENSG00000089902 E018 1.5815120 0.0306424337 8.614974e-01 9.311842e-01 14 102724864 102724913 50 + 0.402 0.433 0.166
ENSG00000089902 E019 73.4318264 0.0064377082 6.786308e-01 8.218435e-01 14 102726468 102726561 94 + 1.883 1.862 -0.071
ENSG00000089902 E020 955.7211146 0.0001696027 1.497885e-05 2.979332e-04 14 102726562 102729875 3314 + 2.959 3.002 0.144
ENSG00000089902 E021 235.0733272 0.0009890172 1.659086e-13 1.975814e-11 14 102729876 102730561 686 + 2.265 2.461 0.653