ENSG00000089693

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000203630 ENSG00000089693 HEK293_OSMI2_6hA HEK293_TMG_6hB MLF2 protein_coding protein_coding 277.958 411.5578 140.1821 82.22241 4.996422 -1.553725 228.1275 385.87832 98.63711 85.446738 7.344165 -1.967835 0.8068083 0.92713333 0.7039667 -0.2231667 0.02018611 0.02018611 FALSE TRUE
ENST00000435120 ENSG00000089693 HEK293_OSMI2_6hA HEK293_TMG_6hB MLF2 protein_coding protein_coding 277.958 411.5578 140.1821 82.22241 4.996422 -1.553725 37.1346 8.56661 30.64641 5.582863 6.873846 1.837709 0.1322167 0.02243333 0.2184000 0.1959667 0.42728657 0.02018611 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000089693 E001 38.2975850 0.0009950928 0.001273510 0.01196323 12 6747996 6748003 8 - 1.215 1.483 0.935
ENSG00000089693 E002 190.0089156 0.0018672297 0.721724301 0.84913771 12 6748004 6748027 24 - 2.166 2.128 -0.126
ENSG00000089693 E003 3609.5297802 0.6010619625 0.405712943 0.63283602 12 6748028 6748547 520 - 3.408 3.407 -0.005
ENSG00000089693 E004 53.1106237 0.1030824579 0.805565475 0.89941386 12 6748721 6748769 49 - 1.644 1.577 -0.230
ENSG00000089693 E005 916.4609479 0.0007758289 0.004072504 0.02957897 12 6748770 6748794 25 - 2.778 2.823 0.149
ENSG00000089693 E006 1408.8256464 0.0014202337 0.004384123 0.03128651 12 6748795 6748881 87 - 2.957 3.009 0.170
ENSG00000089693 E007 1835.5862662 0.1094858217 0.254959347 0.49355353 12 6748882 6748982 101 - 3.076 3.120 0.144
ENSG00000089693 E008 14.3864352 0.0950805629 0.197972959 0.42710534 12 6749787 6749847 61 - 1.266 0.995 -0.972
ENSG00000089693 E009 2821.2752507 0.3266478489 0.395418550 0.62467125 12 6749848 6750007 160 - 3.324 3.296 -0.094
ENSG00000089693 E010 10.4073540 0.0057728170 0.003948789 0.02885769 12 6750145 6750176 32 - 1.214 0.850 -1.336
ENSG00000089693 E011 1655.2716363 0.1565824398 0.566287360 0.74752713 12 6750177 6750211 35 - 3.127 3.058 -0.232
ENSG00000089693 E012 2177.1719251 0.2503510808 0.475815109 0.68406956 12 6750212 6750305 94 - 3.238 3.178 -0.197
ENSG00000089693 E013 21.1431882 0.1936540245 0.204371510 0.43506635 12 6750306 6750343 38 - 1.461 1.140 -1.126
ENSG00000089693 E014 46.4687696 0.2679614806 0.144931910 0.35486091 12 6750344 6750712 369 - 1.838 1.446 -1.335
ENSG00000089693 E015 1384.2609561 0.0645788678 0.693484387 0.83133633 12 6750713 6750744 32 - 3.041 2.982 -0.195
ENSG00000089693 E016 1259.8228902 0.0003941029 0.944005647 0.97433918 12 6750745 6750766 22 - 2.972 2.951 -0.068
ENSG00000089693 E017 14.7085443 0.1247600232 0.103838833 0.28858886 12 6750767 6750948 182 - 1.346 0.980 -1.309
ENSG00000089693 E018 3.4335349 0.7610119922 0.259238881 0.49812995 12 6751125 6751156 32 - 0.744 0.487 -1.136
ENSG00000089693 E019 1230.1232911 0.0001851754 0.671473235 0.81722578 12 6751641 6751676 36 - 2.958 2.943 -0.050
ENSG00000089693 E020 10.6051486 0.0032603383 0.039557610 0.15361273 12 6751822 6751924 103 - 1.149 0.882 -0.981
ENSG00000089693 E021 2127.3498591 0.1848420543 0.310484511 0.55097742 12 6751925 6752054 130 - 3.164 3.180 0.052
ENSG00000089693 E022 12.8696911 0.0522258687 0.094519043 0.27211479 12 6752055 6752284 230 - 1.247 0.949 -1.077
ENSG00000089693 E023 1765.2345942 0.0857030390 0.220440100 0.45406447 12 6752285 6752362 78 - 3.053 3.104 0.168
ENSG00000089693 E024 4.5956949 0.0791539249 0.655690172 0.80713723 12 6752363 6752642 280 - 0.520 0.658 0.616
ENSG00000089693 E025 1.0423134 0.1016590542 1.000000000   12 6752643 6752881 239 - 0.000 0.260 10.372
ENSG00000089693 E026 0.7794795 0.0193695667 1.000000000   12 6752882 6752938 57 - 0.248 0.188 -0.510
ENSG00000089693 E027 1722.5054531 1.1213831061 0.552101613 0.73777830 12 6752939 6753265 327 - 3.055 3.091 0.118
ENSG00000089693 E028 1.7798384 4.2310111977 0.405801406 0.63290425 12 6767141 6767475 335 - 0.980 0.000 -16.295