ENSG00000089486

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000562334 ENSG00000089486 HEK293_OSMI2_6hA HEK293_TMG_6hB CDIP1 protein_coding protein_coding 43.17273 65.8944 19.09557 13.94641 0.7944922 -1.786381 5.419804 6.947130 5.7858336 0.4671498 0.4931205 -0.2634761 0.16003750 0.1223000 0.30213333 0.17983333 0.07665029 0.00222489 FALSE TRUE
ENST00000563332 ENSG00000089486 HEK293_OSMI2_6hA HEK293_TMG_6hB CDIP1 protein_coding protein_coding 43.17273 65.8944 19.09557 13.94641 0.7944922 -1.786381 4.247722 7.492208 0.5673395 0.8070673 0.1037141 -3.6998234 0.09557083 0.1211000 0.03026667 -0.09083333 0.00222489 0.00222489 FALSE TRUE
ENST00000564828 ENSG00000089486 HEK293_OSMI2_6hA HEK293_TMG_6hB CDIP1 protein_coding protein_coding 43.17273 65.8944 19.09557 13.94641 0.7944922 -1.786381 10.379483 15.052971 1.1458390 3.8946518 0.5835865 -3.7039941 0.20988333 0.2222333 0.06006667 -0.16216667 0.52091866 0.00222489   FALSE
ENST00000567695 ENSG00000089486 HEK293_OSMI2_6hA HEK293_TMG_6hB CDIP1 protein_coding protein_coding 43.17273 65.8944 19.09557 13.94641 0.7944922 -1.786381 22.714784 35.805456 11.3070969 9.8403933 0.6950153 -1.6620784 0.52438333 0.5244667 0.59160000 0.06713333 0.76085109 0.00222489 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000089486 E001 0.0000000       16 4510669 4510674 6 -      
ENSG00000089486 E002 1.7365830 0.0125987286 3.831103e-02 0.150419467 16 4510675 4510738 64 - 0.645 0.282 -1.900
ENSG00000089486 E003 420.4919833 0.0043307311 1.995755e-01 0.429127733 16 4510739 4511420 682 - 2.545 2.504 -0.139
ENSG00000089486 E004 728.1518612 0.0012004537 2.270404e-02 0.104980602 16 4511421 4511805 385 - 2.703 2.761 0.192
ENSG00000089486 E005 421.0680412 0.0003448252 1.082140e-03 0.010544654 16 4511806 4511932 127 - 2.445 2.532 0.289
ENSG00000089486 E006 874.3580755 0.0019795655 7.229066e-01 0.849910437 16 4511933 4512398 466 - 2.831 2.828 -0.011
ENSG00000089486 E007 295.2215796 0.0008686450 2.019284e-01 0.431999138 16 4512399 4512453 55 - 2.387 2.355 -0.104
ENSG00000089486 E008 454.1926070 0.0026743113 1.857714e-01 0.411572337 16 4512454 4512611 158 - 2.580 2.538 -0.138
ENSG00000089486 E009 282.8506880 0.0006291929 5.264656e-03 0.036004338 16 4512612 4512683 72 - 2.402 2.332 -0.236
ENSG00000089486 E010 156.3890500 0.0003106343 1.633289e-02 0.083012635 16 4512791 4512797 7 - 2.151 2.076 -0.248
ENSG00000089486 E011 251.4536261 0.0013368501 1.197136e-02 0.066338592 16 4512798 4512866 69 - 2.354 2.279 -0.251
ENSG00000089486 E012 189.2412017 0.0008459821 9.392012e-02 0.270983139 16 4512867 4512915 49 - 2.214 2.164 -0.168
ENSG00000089486 E013 121.8924797 0.0019211255 7.249076e-01 0.851046482 16 4512916 4512947 32 - 1.990 1.984 -0.018
ENSG00000089486 E014 130.4202971 0.0008764262 9.331295e-01 0.968742214 16 4512948 4512998 51 - 2.005 2.018 0.045
ENSG00000089486 E015 89.9630990 0.0013119523 7.309879e-01 0.854795732 16 4512999 4513013 15 - 1.835 1.862 0.092
ENSG00000089486 E016 96.0411058 0.0057507962 5.594174e-01 0.742908637 16 4513014 4513064 51 - 1.843 1.891 0.161
ENSG00000089486 E017 1.1008357 0.4661569503 7.199792e-02   16 4513694 4513695 2 - 0.582 0.122 -3.126
ENSG00000089486 E018 119.0845549 0.0025056089 3.268910e-01 0.566053032 16 4513696 4513815 120 - 1.922 1.982 0.202
ENSG00000089486 E019 81.5387961 0.0058002863 9.470766e-01 0.975850526 16 4513816 4513851 36 - 1.807 1.811 0.014
ENSG00000089486 E020 1.9593859 0.0121869059 6.349049e-01 0.793496068 16 4514045 4514045 1 - 0.484 0.402 -0.426
ENSG00000089486 E021 159.9315735 0.0142147165 2.161061e-01 0.448778878 16 4514046 4514144 99 - 2.027 2.108 0.271
ENSG00000089486 E022 1.7477294 0.1081149053 6.940646e-02 0.223569091 16 4514145 4514149 5 - 0.647 0.280 -1.923
ENSG00000089486 E023 178.7672683 0.0720358941 3.602975e-01 0.595935312 16 4514575 4514630 56 - 2.074 2.155 0.270
ENSG00000089486 E024 166.2570259 0.1167462863 3.284002e-01 0.567413133 16 4514631 4514664 34 - 2.027 2.126 0.333
ENSG00000089486 E025 3.7004219 0.8319712679 4.925427e-01 0.695691464 16 4514665 4515109 445 - 0.957 0.432 -2.238
ENSG00000089486 E026 0.6841482 0.3578127237 2.296169e-01   16 4522417 4522525 109 - 0.377 0.117 -2.154
ENSG00000089486 E027 2.1306449 0.0100945854 8.070832e-01 0.900362590 16 4523827 4524302 476 - 0.374 0.428 0.301
ENSG00000089486 E028 3.1006597 0.0118068850 3.695532e-01 0.603691630 16 4536440 4536768 329 - 0.374 0.556 0.928
ENSG00000089486 E029 44.4059572 0.0199191995 7.500866e-06 0.000163394 16 4538325 4538701 377 - 1.101 1.604 1.753
ENSG00000089486 E030 121.5950573 0.9335820440 5.819398e-01 0.758372349 16 4538702 4538828 127 - 1.940 1.982 0.142