ENSG00000089057

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000338244 ENSG00000089057 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC23A2 protein_coding protein_coding 16.69979 17.05104 17.42489 1.543788 0.6073363 0.03127148 13.535511 15.252015 13.253063 1.1922378 0.802425 -0.2025314 0.8209750 0.89636667 0.7595333 -0.13683333 0.007401453 0.00216511 FALSE TRUE
MSTRG.20310.3 ENSG00000089057 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC23A2 protein_coding   16.69979 17.05104 17.42489 1.543788 0.6073363 0.03127148 2.075146 1.188397 2.875216 0.1452333 0.195871 1.2675731 0.1137958 0.06946667 0.1659333 0.09646667 0.002165110 0.00216511 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000089057 E001 0.6151152 0.3579122399 0.327846263   20 4852356 4852357 2 - 0.305 0.114 -1.762
ENSG00000089057 E002 354.6979162 1.2499842918 0.339542468 0.57759217 20 4852358 4853045 688 - 2.320 2.686 1.218
ENSG00000089057 E003 210.2750968 1.0308845712 0.289709941 0.53026376 20 4853046 4853358 313 - 2.082 2.464 1.274
ENSG00000089057 E004 1353.1331259 1.8512087334 0.511465185 0.70908992 20 4853359 4856710 3352 - 2.977 3.234 0.853
ENSG00000089057 E005 269.2660946 1.2398191594 0.501536037 0.70190825 20 4856711 4857204 494 - 2.311 2.515 0.683
ENSG00000089057 E006 104.3564149 0.0004751115 0.040569133 0.15623473 20 4859289 4859366 78 - 1.993 2.046 0.180
ENSG00000089057 E007 77.1950653 0.0011047114 0.001774230 0.01552799 20 4859367 4859384 18 - 1.892 1.889 -0.011
ENSG00000089057 E008 124.1960777 0.0143467521 0.081278451 0.24740238 20 4861948 4862085 138 - 2.073 2.117 0.148
ENSG00000089057 E009 83.2716214 0.0528828100 0.176023701 0.39850257 20 4862778 4862907 130 - 1.912 1.935 0.080
ENSG00000089057 E010 82.3067949 0.0441146532 0.009962791 0.05800573 20 4867770 4867875 106 - 1.970 1.868 -0.344
ENSG00000089057 E011 2.5573469 0.0366270962 0.008067929 0.04963124 20 4869588 4869905 318 - 0.704 0.348 -1.722
ENSG00000089057 E012 92.9243874 0.0583149680 0.023863853 0.10867769 20 4869906 4870053 148 - 2.020 1.923 -0.327
ENSG00000089057 E013 1.8088244 0.1315204437 0.149712609 0.36187348 20 4873877 4873935 59 - 0.530 0.349 -0.957
ENSG00000089057 E014 116.4207948 0.0824495809 0.064384222 0.21254027 20 4873936 4874092 157 - 2.116 2.022 -0.316
ENSG00000089057 E015 97.9015049 0.0585031346 0.139615113 0.34689906 20 4874576 4874696 121 - 2.000 1.989 -0.036
ENSG00000089057 E016 128.9266055 0.0350889525 0.046687560 0.17178459 20 4883642 4883823 182 - 2.121 2.105 -0.053
ENSG00000089057 E017 87.8382323 0.0466745615 0.051195800 0.18255973 20 4884753 4884823 71 - 1.969 1.928 -0.138
ENSG00000089057 E018 83.9530380 0.0654836778 0.131569703 0.33429546 20 4885821 4885909 89 - 1.938 1.919 -0.066
ENSG00000089057 E019 0.1779838 0.2248868247 0.336056015   20 4885910 4885991 82 - 0.127 0.000 -16.374
ENSG00000089057 E020 118.8407827 0.0550256934 0.223863243 0.45805538 20 4899555 4899712 158 - 2.059 2.092 0.111
ENSG00000089057 E021 108.6350232 0.0675017000 0.154826176 0.36912882 20 4902442 4902558 117 - 2.044 2.034 -0.035
ENSG00000089057 E022 106.4518715 0.0730842560 0.098261091 0.27872890 20 4912880 4912978 99 - 2.056 2.006 -0.170
ENSG00000089057 E023 139.5898928 0.0891157302 0.037737000 0.14892316 20 4932455 4932716 262 - 2.207 2.086 -0.404
ENSG00000089057 E024 30.6930520 0.0627381671 0.046059389 0.17018284 20 4970793 4970915 123 - 1.542 1.461 -0.276
ENSG00000089057 E025 5.1364914 0.0060266157 0.304353675 0.54491030 20 4970916 4970919 4 - 0.642 0.890 0.998
ENSG00000089057 E026 0.3447487 0.2189001646 0.424922512   20 4971662 4971783 122 - 0.000 0.210 17.067
ENSG00000089057 E027 31.7306011 0.0851813794 0.302314864 0.54288995 20 5001406 5001510 105 - 1.510 1.518 0.028
ENSG00000089057 E028 0.0000000       20 5010182 5010293 112 -